Biological monitoring of exposure to polycyclic aromatic hydrocarbons by determination of unmetabolized compounds in urine

Simple Isotope Dilution Headspace-GC-MS Analysis of Naphthalene and p-Dichlorobenzene in Whole Blood and Urine

“…The method does not require any special device, such as purge-and-trap, 4 cryofocusing, 20 cryogenic oven temperature 17 or solid-phase microextraction, [9][10][11]13 but only requires the usual GC-MS instrument with a headspace autosampler, easily obtainable stable isotopes of naphthalene and p-dichlorobenzene, and some HS glass vials for incubation. If a headspace autosampler is not available, it is possible to manually inject the headspace vapor into GC by heating a gas-tight syringe at more than 80 C beforehand.…”

“…However, the recovery rates are low, especially for lipophilic compounds present in various matrices containing large amounts of lipids and/or proteins, such as whole blood and tissue homogenates. 18,19 This is probably the reason why most of the previous studies [4][5][6][7][8][9][10][11][12] on the analysis of polycyclic aromatic hydrocarbons or volatile organic compounds including naphthalene and/or p-dichlorobenzene did not deal with whole blood samples. However, in postmortem forensic toxicological analysis, hemolyzed whole blood should be frequently analyzed.…”

Naphthalin/Naphthole und Human- Biomonitoring

“…Die gemessenen Konzentrationen korrelierten mit denen der Naphthole [29]. Unmetabolisiertes Naphthalin wurde ebenfalls schon im Urin von PAH-belasteten Arbeitern gemessen [48].…”

Investigação do Potencial de Contaminação Ambiental Associado à Disposição em Solo de Resíduos Asfálticos

“…Estes compostos são dificilmente degradáveis e tendem a se acumular nos mais diversos setores ambientais, devido a suas propriedades físico-químicas (COTTA et al, 2009). Estudos em matrizes ambientais, como derivados da combustão de carvão, exaustão dos veículos, óleos lubrificantes, fumaça do cigarro, dentre outros, têm demonstrado que os HPAs presentes nestas misturas são os principais responsáveis pelo seu potencial de toxicidade (Campo et al, 2006). Vários trabalhos têm relatado efeitos adversos produzidos pelos HPAs, principalmente os relacionados ao desenvolvimento de câncer.…”