“…Older individuals with high titers of CMV IgG and plasma IL-6 are at greater risk of frailty (Wang and Casolaro, 2014). Functional decline in humans is associated with increased plasma uric acid, WBCs, ESR, triglycerides, homocysteine, glucose, HbA1c, creatinine, cystatin C, IGF-1, fibrinogen, von Willebrand Factors VIII and IX, oxidized proteins, 8-oxodG, protein carbonylation, C-reactive protein, IL-6, and IL-1RA and decreased plasma Hgb, total cholesterol, HDL, vitamin D, testosterone, adiponectin, vitamin C and E, selenium, magnesium, and carotenoids (Lippi et al, 2014). Many of these factors increase with age in mice as well (Spaulding et al, 1997; Yamato et al, 2014).…”