Biological markers in cord blood for prediction of bronchopulmonary dysplasia in premature infants

Tian, Xiuying; Zhang, X D; Li, Q L; Shen, Yu-Zen; Jun, Zheng

doi:10.12891/ceog16292014

Cited by 11 publications

(3 citation statements)

References 29 publications

(32 reference statements)

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“…Though a large number of studies tried to explore the correlation between biomarkers and BPD, few biomarkers were included in prediction models. Of the studies included in this systematic review, only two studies constructed prediction models with biomarkers, including interleukin-6, clara cell protein-16, and Krebs von den Lungen-6 ( 25 , 26 ). Genome-wide association studies and candidate gene studies investigating the correlation between genetic predisposition and BPD have been reported, but the results of different population studies are inconsistent ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Prediction Models for Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review

et al. 2022

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ObjectiveTo provide an overview and critical appraisal of prediction models for bronchopulmonary dysplasia (BPD) in preterm infants.MethodsWe searched PubMed, Embase, and the Cochrane Library to identify relevant studies (up to November 2021). We included studies that reported prediction model development and/or validation of BPD in preterm infants born at ≤32 weeks and/or ≤1,500 g birth weight. We extracted the data independently based on the CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies (CHARMS). We assessed risk of bias and applicability independently using the Prediction model Risk Of Bias ASsessment Tool (PROBAST).ResultsTwenty-one prediction models from 13 studies reporting on model development and 21 models from 10 studies reporting on external validation were included. Oxygen dependency at 36 weeks’ postmenstrual age was the most frequently reported outcome in both development studies (71%) and validation studies (81%). The most frequently used predictors in the models were birth weight (67%), gestational age (62%), and sex (52%). Nearly all included studies had high risk of bias, most often due to inadequate analysis. Small sample sizes and insufficient event patients were common in both study types. Missing data were often not reported or were discarded. Most studies reported on the models’ discrimination, while calibration was seldom assessed (development, 19%; validation, 10%). Internal validation was lacking in 69% of development studies.ConclusionThe included studies had many methodological shortcomings. Future work should focus on following the recommended approaches for developing and validating BPD prediction models.

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Section: Discussionmentioning

confidence: 99%

Prediction Models for Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review

et al. 2022

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“…A study evaluating the levels of IL-6 and soluble gp130 (Sgp130) in the UCB of 134 preterm infants found that these biomarkers may be used as independent predictors of BPD. The area under the curve (AUC) was 0.849 when IL-6 was >46.125 pg·mL −1 , demonstrating a positive predictive efficacy on BPD [ 13 ].…”

Section: Biofluid Biomarkersmentioning

confidence: 99%

Early prediction of bronchopulmonary dysplasia: can noninvasive monitoring methods be essential?

Cui

2023

ERJ Open Res

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Despite remarkable breakthroughs in diagnosis and treatment, the prevalence of bronchopulmonary dysplasia (BPD) in preterm infants and the consequent mortality have remained high over the last half-century. The pathophysiology of BPD is complicated, with several causes. In addition, infants with severe BPD are predisposed to a variety of complications that need multidisciplinary collaboration during hospitalisation and post-discharge home treatment. Consequently, early prediction, precise prevention, and individualised management have become the cornerstones of therapeutic care of preterm infants with BPD, thereby improving patient survival and prognosis. BPD has an operational clinical description; however, it has various clinical phenotypes and endotypes, making accurate prediction challenging. Currently, most approaches for predicting BPD in preterm infants include invasive collection of biofluids, which is inappropriate in fragile neonates. Consequently, researchers and clinicians are becoming more interested in noninvasive monitoring for BPD prediction. Comprehensive assessments of pertinent research, however, remain scarce. In this review, we compared many noninvasive monitoring techniques that contribute to early prediction of BPD development in premature infants.

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“…[ 8 ] In addition, several studies have shown that several inflammatory mediators in the cord blood of premature infants are associated with the occurrence of ROP. [ 9 , 10 ] Moreover, other studies have shown that some inflammatory mediators in amniotic fluid (AF) and cord blood are higher or lower than normal in very low birth weight (VLBW) infants with bronchopulmonary dysplasia (BPD) [ 11 , 12 ] or preeclampsia, [ 13 ] which are associated with the development of ROP. Thus, prenatal and perinatal infections and inflammation, including chorioamnionitis, appear to be risk factors for ROP development.…”

Section: Introductionmentioning

confidence: 99%

The association between amniotic fluid-derived inflammatory mediators and the risk of retinopathy of prematurity

et al. 2022

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Prenatal and perinatal infections and inflammation appear to associated with the development of retinopathy of prematurity (ROP). In this study, we evaluated whether inflammatory mediators in amniotic fluid (AF) retrieved during cesarean delivery influence the development of ROP in very low birth weight (VLBW) infants. This retrospective study included 16 and 32 VLBW infants who did and did not develop any stage of ROP, respectively. Each infant with ROP was matched with 2 infants without ROP based on days of ventilation care, gestational age, and birth weight. AF was obtained during cesarean delivery, and the levels of intra-amniotic inflammatory mediators such as interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, matrix metalloproteinase (MMP)-2, MMP-8, MMP-9, and tumor necrosis factor (TNF)-α were measured using a Human Magnetic Luminex assay (R&D Systems, Minneapolis, MN). The differences in the levels of inflammatory mediators according to the presence or absence of ROP were compared. In patients who developed ROP, the level of MMP-2 in the AF was significantly increased (P = .011), whereas the levels of IL-10 and TNF-α were significantly decreased (P = .028 and .046, respectively) compared with those in infants who did not develop ROP. The levels of the other mediators were not significantly different between the 2 groups. Multivariate regression analysis showed that MMP-2 was a risk factor for the development of ROP (odds ratio, 2.445; 95% confidence interval, 1.170-5.106; P = .017). The concentration of MMP-2 in AF is an independent factor in the development of ROP. Further studies are needed to determine whether the levels of inflammatory mediators in AF affect the ROP severity.

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Biological markers in cord blood for prediction of bronchopulmonary dysplasia in premature infants

Cited by 11 publications

References 29 publications

Prediction Models for Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review

Prediction Models for Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review

Early prediction of bronchopulmonary dysplasia: can noninvasive monitoring methods be essential?

The association between amniotic fluid-derived inflammatory mediators and the risk of retinopathy of prematurity

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