Biological Markers and Prognosis in Recurrent Oral Cancer After Salvage Surgery

Agra, Ivan Marcelo Gonçalves; Carvalho, André Lopes; Pinto, Clóvis Antônio Lopes; Martins, Everton Pontes; Filho, João Gonçalves; Soares, Fernando Augusto; Kowalski, Luiz Paulo

doi:10.1001/archotol.134.7.743

Cited by 51 publications

(42 citation statements)

References 19 publications

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“…We found a prognostic value in univariate analysis showing significantly higher OS in patients with a disease-free interval of more than 12 months from initial treatment than those with less than 12 months. Consistent with these data, Agra et al 19,21 demonstrated that patients with recurrent disease occurring less than 1 year from initial treatment had a significantly worse prognosis than those with recurrent disease after 1 year, and Schwartz et al 10 reported that oral cancer patients with recurrence within 6 months had a worse salvage rate than those with recurrence after more than 6 months.…”

Section: Discussionmentioning

confidence: 83%

Prognostic factors and outcomes for salvage surgery in patients with recurrent squamous cell carcinoma of the tongue

Goto¹,

Hanai²,

Ozawa³

et al. 2013

Asia-Pac J Clncl Oncology

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Section: Discussionmentioning

confidence: 83%

Prognostic factors and outcomes for salvage surgery in patients with recurrent squamous cell carcinoma of the tongue

Goto¹,

Hanai²,

Ozawa³

et al. 2013

Asia-Pac J Clncl Oncology

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“…EGFR activation can enhance the malignant potential of epithelial tissues 37 . In some studies, EGFR overexpression had been correlated with poor prognostic in OSCC patients 2,38,73,74 , but these results were not confirmed in other investigations 19,75 . A single study had identified a significant association between the combined expression of EGFR, p53, and cyclin D1 and an unfavourable overall survival (OS) in OSCC patients 72 .…”

Section: Cell Cycle Acceleration and Proliferation Moleculesmentioning

confidence: 80%

“…Give rationale for sample size; if the study was designed to detect a specified effect size, give the target power and effect size. According to AGRA et al 2 , the poor prognosis of OSCC patients associated with EGFR overexpression is related to radiotherapy resistance. No influence on OSCC survival was found in the studies examining PCNA expression.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of immunohistochemical biomarkers in oral squamous cell carcinoma

Oliveira

Ribeiro‐Silva

2011

International Journal of Oral and Maxillofacial Surgery

105

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Advances in understanding of the molecular mechanisms underlying oral squamous cell carcinoma (OSCC) have resulted in an increasing number of biomarkers that can be used to predict the behaviour of this disease. The authors conducted a literature review of studies examining the role of immunohistochemistry-based protein biomarkers in predicting OSCC outcome. Only articles published in PubMed-indexed journals over the past 5 years were considered. 22 molecular biomarkers were identified and classified into five groups based on their biological functions: cell cycle acceleration and proliferation; tumour suppression and apoptosis; hypoxia; angiogenesis; and cell adhesion and matrix degradation. The cell cycle acceleration and proliferation biomarkers showed the most divergent prognostic findings. Studies on tumour suppression and apoptosis biomarkers were the most prevalent. There were only a few studies examining molecular biomarkers of hypoxia and angiogenesis, and studies examining cell adhesion and matrix degradation biomarkers have shown that this group has the greatest potential for assessing prognostic parameters. Amongst the several proteins analysed, the immunohistochemical expression levels of epithelial growth factor receptor (EGFR), p53, and matrix metalloproteinases (MMPs) have demonstrated the greatest potential for survival prediction in OSCC, but this review demonstrates that their prognostic relevance is debatable and requires further standardisation.

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“…Investigation of biomarkers' presence, quantity and expression pattern would help to correlate to the probability of malignant transformation of a cell or tissue. Evaluation of biomarkers would also help to identify patients who require more aggressive management (Agra et al, 2008). Immunohistochemical analysis of biomarkers could help to establish a direct association between the morphology and the biomarkers, which can aid in determining their functional relevance (Garcıa-Montesinos-Perea et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Proapoptotic, Anti-Cell Proliferative, Anti-Inflammatory And Antiangiogenic Potential Of Carnosic Acid During 7,12 Dimethylbenz[A]Anthracene-Induced Hamster Buccal Pouch Carcinogenesis

Rajasekaran¹,

Manoharan²,

Silvan³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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The present study has investigated the modulating effect of carnosic acid on the expression pattern of cell proliferative (proliferating cell nuclear antigen (PCNA) cyclin D1 and a transcription factor c-fos), apoptotic (p53, Bcl-2, Bax caspase -3 and 9), inflammatory (Nuclear factor kappa B (NFκB) and cyclooxygenase-2 (COX-2) and angiogenic (vascular endothelial growth factor (VEGF) markers during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. Oral tumors were developed in the hamsters buccal pouches by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Hundred per cent tumour formation (well-differentiated squamous cell carcinoma) accompanied by deregulation in the above mentioned molecular markers was noticed in hamsters treated with DMBA alone (tumour bearing hamsters). Oral administration of carnosic acid at dose of 10mg/kg bw to hamsters treated with DMBA not only completely prevented the tumour formation, but also corrected the abnormalities in the expression pattern of molecular markers. The present study suggests that carnosic acid might have inhibited the tumour formation by exerting anti-cell-proliferative, anti-inflammatory, anti-angiogenic and apoptotic potential during DMBA-induced hamster buccal pouch carcinogenesis.

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Biological Markers and Prognosis in Recurrent Oral Cancer After Salvage Surgery

Abstract: To analyze the prognostic effect of epidermal growth factor receptor (EGFR), matrix metalloproteinases 2 and 9, and vascular endothelial growth factor expression in patients with locally recurrent oral carcinoma after salvage surgery.

Cited by 51 publications

References 19 publications

Prognostic factors and outcomes for salvage surgery in patients with recurrent squamous cell carcinoma of the tongue

Prognostic factors and outcomes for salvage surgery in patients with recurrent squamous cell carcinoma of the tongue

Prognostic significance of immunohistochemical biomarkers in oral squamous cell carcinoma

Proapoptotic, Anti-Cell Proliferative, Anti-Inflammatory And Antiangiogenic Potential Of Carnosic Acid During 7,12 Dimethylbenz[A]Anthracene-Induced Hamster Buccal Pouch Carcinogenesis

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