Biological markers and possibilities for predicting therapeutic results in schizophrenia

Češková, Eva; Drybčák, Pavel; Lorenc, Miroslav

doi:10.1016/s0278-5846(01)00318-9

Cited by 9 publications

(3 citation statements)

References 34 publications

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“…But no single factor was a strong prediction factor. A combination of the factors seemed to be more promising (Awad et al 1994; Češková et al 2002). Of interest is also the association between conceptual disorganization and negative symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…The Department of Psychiatry of Brno has long-standing experience with patients suffering from first-episode schizophrenia. In addition to a detailed clinical evaluation and a neurological examination focused on soft neurological signs; endocrine, neuroanatomical, and functional brain parameters are monitored and cognitive dysfunction is evaluated ( Češková et al 2002 ). This article reports the results of the response of patients with first-episode schizophrenia to treatment based on the psychopathology of the initial treatment phase.…”

Section: Introductionmentioning

confidence: 99%

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Psychopathology and treatment responsiveness of patients with first-episode schizophrenia

Češková¹,

Přikryl²,

Kašpárek³

et al. 2005

nedt

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One hundred and four male patients hospitalized for the first time with the diagnosis of first-episode schizophrenia were comprehensively assessed on admission and discharge. Psychopathology, treatment response, and remission rates were evaluated (based on the Positive and Negative Syndrome Scale (PANSS), severity of symptoms only). On admission, the most frequently observed symptoms were lack of judgment and insight (87.6%), suspiciousness/feelings of persecution (82.3%), delusions (77%), poor attention (70%), disturbance of volition (65.4%), conceptual disorganization (64.7%), and active social avoidance (64%). Except for delusions and hallucinations, the positive items of the PANSS correlated significantly with negative symptoms, and conceptual disorganization correlated with the greatest number of negative symptoms. Individual negative symptoms were present in about half the patients. At discharge, the most frequent symptoms were again lack of judgment and insight (in 55.7%), and for negative symptoms they were blunted affect (22.1%), emotional withdrawal (21.2%), and passive/apathetic social withdrawal (19.5%). The positive symptoms of suspiciousness/feelings of persecution and grandiosity persisted in 20.6% of patients. On average, all symptoms were significantly reduced 44 days after admission. The negative symptoms improved less, compared with the positive ones. At discharge there was a high rate of responders (response defined as minimal 30% reduction of total PANSS): 73% and 74% of patients fulfilled the criteria for remission. On admission, the responders (n = 76) had significantly higher scores of most symptoms, both positive and negative ones than nonresponders (n = 28).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Psychopathology and treatment responsiveness of patients with first-episode schizophrenia

Češková¹,

Přikryl²,

Kašpárek³

et al. 2005

nedt

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“…2 Studies indicate that reducing the duration of untreated psychosis by providing early recognition and intervention is likely to prevent negative symptoms psychopathology in first episode schizophrenia. 28 It was also evident that this sample of patients with first episode schizophrenia predominantly had more positive symptoms like delusion, hallucination and suspiciousness. Similar findings were found in a study from Czech Republic in whose sample, suspiciousness was observed in 82%, delusion in 77% and hallucination in 59% in first episode schizophrenia.…”

Section: Discussionmentioning

confidence: 78%

Clinical correlates of first episode schizophrenia-a comparative study

Kathir¹,

Pugazhendhi²,

Ravishankar³

2018

Int J Res Med Sci

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Background: Schizophrenia is a major mental disorder which has to be assessed early and managed actively even though long term functional outcome remains relatively poor. The aim of the study is to analyze negative symptoms, suicidal risk and substance use in first episode schizophrenics in comparison with multi-episode schizophrenics.Methods: 30 patients with drug naive first episode schizophrenia and 30 patients with multi episode schizophrenia, who attended the outpatient department of Psychiatry, Government Stanley Medical College, Chennai, Tamilnadu, India were studied to compare predisposing factors and spectrum of symptoms for Schizophrenia for a period of one year (January 2010-December 2010). Psychiatric questionnaire by Michael C. Hilton, DAST by Harvey A. Skinner, AUDIT by WHO, Suicide risk scale by National Health and Medical Research Council, PANSS by SR Kay were used to assess patients.Results: Unemployment and family history of suicide attempts were observed more in drug naive first episode schizophrenics. 90% of these patients had completed their primary education while 47% of multi-episode schizophrenics were illiterates. Positive symptoms (delusions, hallucinatory behaviour and suspiciousness) and negative symptoms (blunted affect, emotional withdrawal and social withdrawal) were observed more in first episode schizophrenics while PANSS, DAST, AUDIT scores did not find any differences between both the groups.Conclusions: In our study, the first episode schizophrenia patients were more educated, more unemployed and had more family history of suicide, elevated sub score of positive symptoms as measured by PANSS. Relative assessment of violence and serious behavior problems that are related to positive symptoms must be done and managed with anti psychotics.

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Biological Markers in Psychiatry and Its Relation with Translational Approaches: Brief Historical Review

Gargiulo

et al. 2015

Psychiatry and Neuroscience Update

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Biological markers and possibilities for predicting therapeutic results in schizophrenia

Cited by 9 publications

References 34 publications

Psychopathology and treatment responsiveness of patients with first-episode schizophrenia

Psychopathology and treatment responsiveness of patients with first-episode schizophrenia

Clinical correlates of first episode schizophrenia-a comparative study

Biological Markers in Psychiatry and Its Relation with Translational Approaches: Brief Historical Review

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