Biological insights into the piericidin family of microbial metabolites

Abstract

Extensively produced by members of the genus Streptomyces, piericidins are a large family of microbial metabolites, which consist of main skeleton of 4-pyridinol with methylated polyketide side chain.Nonetheless, these metabolites display differences in their bioactive potentials against microorganisms, insects, and tumor cells. Due to its close structural similarity with coenzyme Q, piericidins also possess an inhibitory activity against NADH dehydrogenase as well as Photosystem II . This review studied the latest research progress of piericidins, covering the chemical structure and physical properties of newly identified members, bioactivities, biosynthetic pathway with gene clusters, and future prospect. With the increasing incidence of drug-resistant human pathogen strains and cancers, this review aimed to provide clues for the development of either new potential antibiotics or anti-tumor agents.

Marine-Derived Piericidin Diglycoside S18 Alleviates Inflammatory Responses in the Aortic Valve via Interaction with Interleukin 37

“…The piericidin family is an important kind of active microbial metabolite that features a 4-pyridinol core linked with a methylated polyketide side chain [23]. Accumulating evidence suggests that natural piericidins obtained from marine-derived Streptomyces have received considerable attention in recent years because of their important medicinal activities [23,24]. Our group has previously obtained 43 natural piericidins from two strains of marine-derived Streptomyces, including 29 new compounds [25][26][27], and found that the main piericidin metabolites, including piericidin A (PA) and glucopiericidin A (GPA), have the potential to be developed as potential antirenal carcinoma drugs.…”

Interactions between plant‐beneficial microorganisms in a consortium: Streptomyces microflavus and Trichoderma harzianum

“…Correspondingly, at the metabolome level, several metabolites were uniquely detected in the co‐cultures or the single cultures (Tables S3 and S4). In AtB‐42, for example, the co‐culturing induced the production of glucopiericidin and hampered that of cyclipostin, ripromycin, WK 142B, delaminomycin A and Formycin A, which are well‐known antibiotics of the Streptomyces genus (Azad et al, 2022; Bertasso et al, 2003; Hori et al, 1964; Omura et al, 1986; Ueno et al, 1993; Wink et al, 2002). It should be mentioned that, besides the huge literature on the co‐cultures of microorganisms, few articles report the enhancement of the overall production of metabolites.…”

A resveratrol oligomer, hopeaphenol suppresses virulence activity of Pectobacterium atrosepticum via the modulation of the master regulator, FlhDC

“…The active compound piericidin A was firstly isolated as an insecticidal agent acting as a NADH–ubiquinone oxidoreductase inhibitor for disrupting mitochondrial respiratory chain ( Tamura et al, 1963 ; Liu et al, 2012 ). Since then, various biological activities in view of insecticidal, antimicrobial, anti-tumor activities, cytotoxicity, and type III secretion system (T3SS) inhibition have been studied intensively ( Tamura et al, 1963 ; Morgan et al, 2017 ; Li et al, 2021 ; Azad et al, 2022 ).…”