Biological indices of kidney involvement in personnel exposed to sevoflurane in surgical areas

Trevisan, Andrea; Venturini, Matteo Borella; Carrieri, Mariella; Giraldo, Mónica; Macca, Isabella; Perini, M; Scapellato, Maria Luisa; Virgili, Annalisa; Bartolucci, Giovanni Battista

doi:10.1002/ajim.10299

Cited by 12 publications

(2 citation statements)

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“…on studying the effect of type of circuit used and kidney functions, the current results showed that all kidney functions parameters were higher among personnel using open and closed circuits than in those using closed circuits only, and this increase was statistically significant for urea and B2 microglobulin (Table 4). This was supported by the environmental results which revealed that isoflurane air level was high in theaters using open and closed circuits than in those using closed circuits only .This concurred with the study done by Trevisan et al, 2003, where they found significantly increased total urinary proteins among all exposed operating room personnel, and being higher among personnel using open more than semiclosed circuits. regarding the type of anesthetic gases used and the kidney, the current study showed that the mean values of urea, creatinine and B2 microglibulin were higher among personnel using isoflurane, sevoflurane and halothane more than those using isoflurane only (Table 3), but this increase was not statistically significant.…”

Section: When It Comes To Renal Affection;supporting

confidence: 84%

Study of Some Health Hazards among Operating Theater Personnel Due to Exposure to Anesthetic Gases (II)

MS¹,

SA²,

et al. 2019

Egypt. J. Occup. Med.

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introduction: Anesthetics are essential materials used in hospitals to induce unconsciousness in patients prior to surgical procedures. The most commonly used agents are isoflurane , sevoflurane and halothane. aim of work: To assess the health effects of exposure to anesthetic gazes focusing on hepatic and renal manifestations among operating room (OR) personnel. materials and methods: Operating room (OR) personnel (184: 68 males and 116 females) were included in the study and compared with 192 (63 males and 129 females) from other departments staff of the same hospital mainly from internal medicine hospital and outpatient clinics. The studied groups filled a questionnaire including personnel, family, past and present histories. Liver and kidney function tests were examined. Plain urine samples were collected at the end of shift to test for β 2 microglobulin. Operating theaters were evaluated regarding the type of breathing circuits used whether open or closed, the type of anesthetic gases used, presence of air conditioning, and scavenging system. Isoflurane air level was measured using the organic method 103 by OSHA. results: OR personnel experienced symptoms namely headache, tiredness, drowsiness, and decreased memory compared with their controls, without having statistical significance except for headache. There was a statistically significant increase in the level of ALP (Alkaline phosphatase), total bilirubin, urea, creatinine and B 2 microglobulin among exposed when compared to the control group. Also AST (Aspartate transaminase), ALP, direct bilirubin, B 2 microglobulin, urea and creatinine were higher among personnel using both open and closed circuits than in those using closed circuits only. The mean values of AST, ALP, total bilirubin, B 2 microglibulin urea and creatinine were higher among personnel using isoflurane, sevoflurane and halothane (3 types of anesthetic gazes) more than those using isoflurane and sevoflurane or those using isoflurane only. The mean levels of urea and creatinine were statistically higher among surgeons when compared to other groups. conclusion: Personnel working in operating theaters are more at risk to develop disturbances in liver and kidney functions compared to the controls especially surgeons. recommendations: Implementation of adequate and working scavenging system, air conditioning, use of closed circuits whenever possible, periodic checking of anesthetic air levels, periodic biochemical analysis for OR personnel, and replacement of any malfunctioning parts of anesthesia machine.

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Section: When It Comes To Renal Affection;supporting

confidence: 84%

Study of Some Health Hazards among Operating Theater Personnel Due to Exposure to Anesthetic Gases (II)

MS¹,

SA²,

et al. 2019

Egypt. J. Occup. Med.

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show abstract

“…In contrast, GS is an enzyme localized exclusively in the early and late portion of the S 3 segment of the proximal tubule (Burch et al, 1978). The measure of its activity in kidney cortex (Trevisan et al, 2001) and its excretion in urine was previously assayed in rats (Trevisan et al, 1999(Trevisan et al, , 2002 and in humans (Trevisan et al, 2000(Trevisan et al, , 2003, appearing an early and sensitive biomarker of segment-specific (S 3 ) toxicity.…”

Section: Discussionmentioning

confidence: 99%

Regucalcin down-regulation in rat kidney tissue after treatment with nephrotoxicants☆

et al. 2008

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Sevofluran [MAK Value Documentation in German language, 2013]

2013

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 54. Lieferung, Ausgabe 2013 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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Biological indices of kidney involvement in personnel exposed to sevoflurane in surgical areas

Abstract: Results show that no relevant effect on the kidney is present for the levels of exposure studied. Nevertheless, correlation between dose and response urinary indices supports that SEV, other than N(2)O, may influence kidney function, especially when open circuits are used.

Cited by 12 publications

References 50 publications

Study of Some Health Hazards among Operating Theater Personnel Due to Exposure to Anesthetic Gases (II)

Study of Some Health Hazards among Operating Theater Personnel Due to Exposure to Anesthetic Gases (II)

Regucalcin down-regulation in rat kidney tissue after treatment with nephrotoxicants☆

Sevofluran [MAK Value Documentation in German language, 2013]

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