Biological importance and therapeutic potential of Trilobatin in the management of human disorders and associated secondary complications

Patel, Kanika

doi:10.1016/j.prmcm.2022.100185

Cited by 9 publications

(2 citation statements)

References 85 publications

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“…Li et al investigated trilobatin anticancer efficacy in gefitinib-resistant lung cancer cells [ 203 ]. Trilobatin (phloretin-4-O-glucoside) is a dihydrochalcone glucoside and derivative of phloretin found in the stems, leaves, flowers and fruits of apple plants [ 204 , 205 ]. Trilobatin has been detected in the leaves of Vitis species , in Lithocarpus polystachyus , and in different Malus species including Malus domestica and Malus trilobata .…”

Section: Cd133 As a Target In Cancer Therapiesmentioning

confidence: 99%

Unmasking the Deceptive Nature of Cancer Stem Cells: The Role of CD133 in Revealing Their Secrets

Pospieszna,

Dams-Kozlowska,

Udomsak

et al. 2023

IJMS

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Cancer remains a leading cause of death globally, and its complexity poses a significant challenge to effective treatment. Cancer stem cells and their markers have become key players in tumor growth and progression. CD133, a marker in various cancer types, is an active research area as a potential therapeutic target. This article explores the role of CD133 in cancer treatment, beginning with an overview of cancer statistics and an explanation of cancer stem cells and their markers. The rise of CD133 is discussed, including its structure, functions, and occurrence in different cancer types. Furthermore, the article covers CD133 as a therapeutic target, focusing on gene therapy, immunotherapy, and approaches to affect CD133 expression. Nanoparticles such as gold nanoparticles and nanoliposomes are also discussed in the context of CD133-targeted therapy. In conclusion, CD133 is a promising therapeutic target for cancer treatment. As research in this area progresses, it is hoped that CD133-targeted therapies will offer new and effective treatment options for cancer patients in the future.

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Section: Cd133 As a Target In Cancer Therapiesmentioning

confidence: 99%

Unmasking the Deceptive Nature of Cancer Stem Cells: The Role of CD133 in Revealing Their Secrets

Pospieszna,

Dams-Kozlowska,

Udomsak

et al. 2023

IJMS

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“…Chalcone, also known as trans-1,3-diphenyl-2-propenone, is an open-chain avonoid compound [32], primarily derived from edible plants like Piper methysticum (Kava-Kava), Aniba riparia, and Didymocarpus corchorijolia [32,33]. Chalcones and its derivatives have been recognized for their potential anti-diabetic, anti-neoplastic, anti-in ammatory, anti-cancer, and hepatoprotective properties [34][35][36]. Previously, studies have highlighted the anti-cancer activity of trans-chalcone in various cancers including HCC by reducing oxidative stress, promoting cell survival, and regulating ER stress [36,37].…”

Section: Introductionmentioning

confidence: 99%

trans-chalcone ameliorates CCl4-induced Acute Liver Injury by Suppressing Oxidative Stress, Inflammation, and Endoplasmic Reticulum Stress

Munakarmi,

Gurau,

Shrestha

et al. 2024

Preprint

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Background Acute liver injury is a sensitive parameter for detecting liver damage due to toxic, viral, metabolic, and autoimmune exposures. Due to the response to adverse external stimuli and various cellular homeostasis, Endoplasmic reticulum stress (ERS), Oxidative stress, and Inflammation have great potential for treating liver injury. Trans-chalcones (TC) is a polyphenolic compound derived from a natural plant with anti-oxidative and anti-inflammatory abilities. Here, TC was aimed to attenuate liver injury by triggering ER stress, oxidative stress, inflammation, and apoptosis. Methods A single dose of carbon tetrachloride (CCl4) 1 mL/kg was administered intraperitoneally into C57BL6 mice to construct an in vivo NAFLD model, whereas AML12 cells were treated with lipopolysaccharides (LPS) to construct an in vitro NAFLD model. The mice used in the experiment were randomly assigned to two groups: a 12-hour set and a 24-hour set. Forty-nine mice were randomly divided into seven groups, the control group (Group I), TC group (Group II) 10 mg/kg TC, negative control group (Group III) CCl4, TC + CCl4 groups (Groups IV − VI), mice were subcutaneously treated with (5, 10, and 20) mg/kg of TC for three consecutive days before the CCl4 injection and the positive control group (Group VII) received 10 mg/kg Silymarin. After the experiment, serum transaminase, liver histological pathology, hepatic expression levels ERS, oxidative stress, and inflammation-related markers were assessed Results TC pre-treatment significantly alleviates the expression of ER stress, oxidative stress, inflammatory cytokines, and apoptosis in both in vivo and in vitro models of liver injury. TC treatment significantly reduced serum transaminase levels (ALT and AST), and ROS levels. The protective effect of TC on the liver injury mouse model was achieved by inhibiting hepatocyte apoptosis. Moreover, TC pre-treatment dramatically decreased the protein levels of ER stress indicators such as CHOP, Bip, Ero-Lα, IRE1α, PERK, Calnexin, and PDI when compared to the CCl4-only treated group. Conclusion TC exerts hepatoprotective effects against CCl4-induced acute liver injuries in mice by modulating ERS, oxidative stress, and inflammation. Further investigations are necessary to elucidate the precise molecular mechanisms underlying the hepatoprotective effects of TC and to explore its therapeutic potential in clinical trials.

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Therapeutic role of columbianadin in human disorders: Medicinal importance, biological properties and analytical aspects

Patel

2023

Pharmacological Research - Modern Chinese Medicine

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Biological importance and therapeutic potential of Trilobatin in the management of human disorders and associated secondary complications

Cited by 9 publications

References 85 publications

Unmasking the Deceptive Nature of Cancer Stem Cells: The Role of CD133 in Revealing Their Secrets

Unmasking the Deceptive Nature of Cancer Stem Cells: The Role of CD133 in Revealing Their Secrets

trans-chalcone ameliorates CCl4-induced Acute Liver Injury by Suppressing Oxidative Stress, Inflammation, and Endoplasmic Reticulum Stress

Therapeutic role of columbianadin in human disorders: Medicinal importance, biological properties and analytical aspects

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