Biological Impact of Melatonin on the Healing of Albino Rats’ Tongue Ulcer.

Amin., LailaE.; Adel, Mohamed

doi:10.21474/ijar01/2996

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Pugazhenthi et al [39], assessed the quality of scarring in full-thickness incisional wounds by histological analysis, the results showed that melatonin treatment improved the quality of the scar. Another histological study performed by Amin et al [40], who found that melatonin treated ulcers had better collagen bundle organization and additional angiogenesis. Further research is required to establish -in greater detail-the effects of melatonin on the wound-healing process.…”

Section: Discussionmentioning

confidence: 96%

Effect of Topical Melatonin Loaded Gelatin Sponge on Palatal Wound Healing (Randomized Controlled Clinical Trial)

nabil,

kotry,

Heikal

et al. 2024

Alexandria Dental Journal

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INTRODUCTION:For many muco-gingival deformities, autogenous soft tissue grafts are the gold standard treatment. The palate is the most typical site for soft tissue graft harvesting. Epithelialized graft harvesting technique is one of the most efficient. Yet, it leaves an open palatal wound that is only healed by secondary intention. Many dressing materials have been used -to cover and protect the donor site-either alone or combined with other biological materials as: non-eugenol and eugenol dressings, Collagen, hydrogels and, resinbased dressings. Melatonin is well known for its anti-oxidant and anti-inflammatory effects; it has the ability to decrease the effects of various pro-inflammatory mediators. It can scavenge free radicals and reduce oxidative stress, which is often associated with inflammation. Melatonin's ability to regulate the immune response and dampen the pro-inflammatory cascade has gained interest for potential therapeutic applications. Study objective: To assess the effect of topically applied melatonin loaded gelatin sponge on palatal wound healing. MATERIALS AND METHODS: Twenty-six surgical sites for free palatal graft procurement were included in the study. They were equally divided into two groups: Test group, the palatal donor site was covered by topical Melatonin loaded gelatin sponge. Control group, the site was covered by carbopol loaded gelatin sponge. Wound healing was evaluated using photo-digital planimetry on the day of surgery and, at seven days post-surgical. Healing index of Landry was used at the seventh day. Pain was assessed via VAS for a week from the day of surgery. RESULTS: Photo-digital planimetry showed that the test group exhibited more reduction in the percentages of wound area than control although it was not statistically significant. Healing index of Landry revealed no statistically significant difference between the two groups. No significant differences in VAS scores between the two groups. CONCLUSION: Melatonin could be beneficial in improving palatal wound healing.

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Section: Discussionmentioning

confidence: 96%

Effect of Topical Melatonin Loaded Gelatin Sponge on Palatal Wound Healing (Randomized Controlled Clinical Trial)

nabil,

kotry,

Heikal

et al. 2024

Alexandria Dental Journal

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“…After anesthesia, the lingual mucosa was antiseptically cleaned with 2% chlorhexidine then a surgical mucosal wound was made by using biopsy punch (Acu-Punch, Acuderm Inc., Ft. Lauderdale, FL, USA) to ensure that all ulcers will have the same size. The ulcer was circular in shape about 4mm in diameter and 2mm in depth (21) .…”

Section: Ulcer Inductionmentioning

confidence: 99%

Impact of Hyaluronic acid on healing of tongue ulcers in diabetic rats

Moawad

Abobaker

2022

Egyptian Dental Journal

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Introduction: Wound healing is a highly complicated process achieved through definitely programmed stages. Hyaluronic acid is a natural component present essentially in the skin and other connective tissues, it has been used in many medical fields for acceleration of wound healing.Aim: This study aimed to investigate the therapeutic effect of hyaluronic acid on healing of tongue ulcer in diabetic rat model. Material & Methods:Thirty male Albino rats were subjected to diabetes induction and after 1 week the animals were classified into 3 groups, Group I: rats were subjected to tongue ulcer and did not receive any treatment. Group II: rats were subjected to tongue ulcer and the ulcers were treated with 3 times/ day topical applications of commercially used 0.2% high molecular weight hyaluronic acid. Group III: rats were received 1-2 IU/ g/day of insulin NPH injected subcutaneous and then subjected to tongue ulcer after one week from the starting of insulin injection. The animals were sacrificed at 4 and 10 days after ulcer induction, specimens were prepared for histological examination and immunohistochemical staining for α-SMA.Results: Histological examination revealed better enhancement of ulcer healing and reepithelization together with reorganization of the epithelium and connective tissue in group II and III samples when compared to group I after 4 and 10 days of ulcer induction. Conclusion:oral application of hyaluronic acid gel has beneficial effects in accelerating wound healing and improving all phases of wound repair in tongue ulcers in rats.

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