2000
DOI: 10.1007/978-3-7091-6346-7_14
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Biological Functions of Extravasated Serum IgG in Rat Brain

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Cited by 14 publications
(6 citation statements)
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“…Increases in BBB permeability permit the entry of blood‐borne xenobiotics and endogenous molecules into the brain, disturbing CNS homeostasis and promoting neuronal dysfunction and death. For example, serum albumin is capable of inducing degeneration of cholinergic neurons (Moser and Humpel 2007), while serum IgG is known to initiate neutorphil infiltration and associated immune response in the brain (Kadota et al. 2000).…”
Section: Discussionmentioning
confidence: 99%
“…Increases in BBB permeability permit the entry of blood‐borne xenobiotics and endogenous molecules into the brain, disturbing CNS homeostasis and promoting neuronal dysfunction and death. For example, serum albumin is capable of inducing degeneration of cholinergic neurons (Moser and Humpel 2007), while serum IgG is known to initiate neutorphil infiltration and associated immune response in the brain (Kadota et al. 2000).…”
Section: Discussionmentioning
confidence: 99%
“…Although there are numerous examples supporting a monoclonal antibody‐induced central nervous system effect,26–28 interparenchymally infused IgG may not necessarily be neurotoxic. For example, the intracortical injection of purified IgG into rodent cortex caused infiltration of neutrophils and cytokine changes in microglia and endothelium but no neuronal damage 29. It is also widely accepted that healthy individuals have serum antibodies directed against neuronal tissues that are generally considered to be largely nonspecific and of little physiological importance 30–35…”
Section: Discussionmentioning
confidence: 99%
“…Cell debris, cytokines and serum components gaining access to the brain through a damaged blood-brain barrier have been implicated as microglial activators (Chamak and Mallat, 1991;Lassmann et al, 1991;Benveniste, 1992;Nakajima and Kohsaka, 2001;Kadota et al, 2000;Lu et al, 2001). The microglial response comprises reactive morphological changes as well as changes in their functional properties, including proliferation, phagocytosis, migration and release of cytokines (Thomas, 1992;Perry et al, 1995;Gehrmann and Kreutzberg, 1995;Giulian, 1995).…”
Section: Introduction Mmentioning
confidence: 99%