Biological functions of CRTC2 and its role in metabolism-related diseases

Abstract

CREB-regulated transcription coactivator2 (CRTC2 or TORC2) is a transcriptional coactivator of CREB(cAMP response element binding protein), which affects human energy metabolism through cyclic adenosine phosphate pathway, Mammalian target of rapamycin (mTOR) pathway, Sterol regulatory element binding protein 1(SREBP1), Sterol regulatory element binding protein 2 (SREBP2) and other substances Current studies on CRTC2 mainly focus on glucose and lipid metabolism, relevant studies show that CRTC2 can participate in the occurrence and development of related diseases by affecting metabolic homeostasis. It has been found that Crtc2 acts as a signaling regulator for cAMP and Ca2 + signaling pathways in many cell types, and phosphorylation at ser171 and ser275 can regulate downstream biological functions by controlling CRTC2 shuttling between cytoplasm and nucleus.

Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo

“…Eight experimental rats that were not successfully modeled were not included in the study. The T2DM rats were randomly divided into three groups (n = 8 each group), which were intragastrically administered metformin (200 mg/kg/day) (17,18) and TAS (80 mg/kg/day) (19,20) for 8 weeks. An equal volume of saline solution was intragastrically administered to the control and model rats.…”