Biological functions of bacterial lysophospholipids

Cao, Xuefeng; Putten, J. P. M. Van; Wösten, Marc M. S. M.

doi:10.1016/bs.ampbs.2022.10.001

Cited by 4 publications

(4 citation statements)

References 143 publications

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“…In this study, a large of DEMs were identified as lipids, accounting for 29.56% of all DEMs, which include lipid metabolites such as lysophospholipid (LPL) and cucurbitacin. LPL is a lipid-derived metabolic intermediate in the cell membrane, which regulates many important biological processes as an important biologically active signaling molecule ( Cao et al., 2023 ). Previous studies have shown that LPL may be involved in the signal transduction of stress response, and its expression is induced by salt and osmotic stresses ( Meijer et al., 2001 ).…”

Section: Discussionmentioning

confidence: 99%

Multi-omics analysis of Populus simonii × P. nigra leaves under Hyphantria cunea stress

Jiang,

Fan,

Wang

et al. 2024

Front. Plant Sci.

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Poplar is an important greening and timber tree species in China, which has great economic and ecological values. However, the spread of Hyphantria cunea has become increasingly serious in recent years, resulting in huge economic loss of poplar production. Exploring the molecular mechanism of poplar reponse to H. cunea stress has significant implications for future development of new insect-resistant poplar varieties using genetic engineering technology. In this study, a total of 1039 differentially expressed genes (DEGs), 106 differentially expressed proteins (DEPs) and 212 differentially expressed metabolites (DEMs) were screened from Populus simonii × P. nigra leaves under H. cunea stress by transcriptome, proteomics and metabolomics analysis, respectively. GO and KEGG analysis showed that the DEGs and DEPs are associated with endopeptidase inhibitor activity, stress response, α-linolenic acid metabolism, phenylpropanoid biosynthesis and metabolic pathways, cysteine and methionine metabolism pathways and MAKP signaling pathway. Metabolomics analysis showed the most of DEMs were lipids and lipid molecules, and the pathways associated with transcriptome mainly include plant hormone signal transduction, α-linolenic acid metabolic pathway, amino sugar and nucleotide sugar metabolism, and phenylpropanoid biosynthesis. In particular, multi-omics analysis showed that several pathways such as α-linolenic acid metabolic, phenylpropanoid biosynthesis and metabolic pathway and cysteine and methionine metabolic pathway were significantly enriched in the three omics, which may play an important role in the resistance to pests in poplar.

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Section: Discussionmentioning

confidence: 99%

Multi-omics analysis of Populus simonii × P. nigra leaves under Hyphantria cunea stress

Jiang,

Fan,

Wang

et al. 2024

Front. Plant Sci.

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“…Furthermore, the abundance of lysophospholipids (LPLs) with carbon chain lengths primarily of 16 and 18 was significantly upregulated in antibiotic-tolerant C. jejuni cells upon exposure to antibiotics (Figure 3EF). LPLs make up a small fraction (<1%) of the bacterial membrane composition and their accumulation is frequently observed in stressed bacteria 80 . These molecules can be generated through bacterial membrane degradation or phospholipid biosynthesis as metabolic intermediates 80 .…”

Section: Metabolic Signatures Of Antibiotic Tolerance In C Jejunimentioning

confidence: 99%

“…LPLs make up a small fraction (<1%) of the bacterial membrane composition and their accumulation is frequently observed in stressed bacteria 80 . These molecules can be generated through bacterial membrane degradation or phospholipid biosynthesis as metabolic intermediates 80 . The most common LPLs include lysophosphatidic acid, lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylglycerol, lysophosphatidylinositol, and lysophosphatidylserine 80 .…”

Section: Metabolic Signatures Of Antibiotic Tolerance In C Jejunimentioning

confidence: 99%

“…These molecules can be generated through bacterial membrane degradation or phospholipid biosynthesis as metabolic intermediates 80 . The most common LPLs include lysophosphatidic acid, lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylglycerol, lysophosphatidylinositol, and lysophosphatidylserine 80 . In response to stress, some pathogens activate phospholipase A1 encoded by the pldA gene to hydrolyze toxic oxidized phospholipids, producing LPLs and free fatty acids [81][82] .…”

Section: Metabolic Signatures Of Antibiotic Tolerance In C Jejunimentioning

confidence: 99%

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Protein quality control modulates the metabolic conservation in antibiotic tolerantCampylobacter jejuni

Feng,

Li,

et al. 2024

Preprint

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Antibiotic tolerance in bacteria emerges as a phenotypic variant known as persisters and has been implicated in recurrent bacterial infections. This tolerance manifests as suppressed metabolism. We demonstrate thatCampylobacter jejunireadily forms persisters in response to both ampicillin and ciprofloxacin. Persisters induced by these two antibiotics with different mechanisms of actions experience consistent metabolic reprogramming, characterized by suppressed respiration and energy metabolism while conserving core metabolic processes. We reveal that the coordination of protein homeostasis underlies the metabolic reprogramming involved in persister formation. Mutating the caseinolytic protease geneclpP, a major component of the protein quality control system, compromises persister formationin vitroand impairs bacterial colonization in mouse. However, the deletion oflon, another component of the protein quality control system, or pre-activation ofclpPby expressing artificial disordered protein fragments does not affect the antibiotic tolerance. This suggests that specific targets of ClpP rather than the entire quality control system are critical for persister formation. Our results reveal a convergent metabolic reprogramming in persisters, highlighting the potential to limit the emergence of antibiotic tolerance by counteracting adaptive metabolism elicited by antibiotic treatment.

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Lysophospholipid remodeling mediated by the LplT and Aas protein complex in the bacterial envelope

Niu,

Vu,

et al. 2024

Journal of Biological Chemistry

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Biological functions of bacterial lysophospholipids

Cited by 4 publications

References 143 publications

Multi-omics analysis of Populus simonii × P. nigra leaves under Hyphantria cunea stress

Multi-omics analysis of Populus simonii × P. nigra leaves under Hyphantria cunea stress

Protein quality control modulates the metabolic conservation in antibiotic tolerantCampylobacter jejuni

Lysophospholipid remodeling mediated by the LplT and Aas protein complex in the bacterial envelope

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