Biological Functions and Applications of Antimicrobial Peptides

Wang, Lei; Qu, Linkai; Lin, Sue; Yang, Qinsi; Zhang, Xingxing; Jin, Libo; Dong, Hao; Sun, Da

doi:10.2174/1389203723666220519155942

Cited by 9 publications

(5 citation statements)

References 211 publications

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“…One of the main defense mechanisms of innate immunity, acting in the prevention and combat of infections in the newborn, are represented by broadspectrum biological molecules called antimicrobial peptides (AMPs), such as LL-37 (Dürr et al, 2006). AMPs are made up of chains with approximately 150 -200 amino acids, produced and expressed by different cell types, such as neutrophils, Paneth cells in the small intestine or epithelial cells, with antifungal, antibacterial, antiviral and antitumor activities of these molecules having been demonstrated (Wang et al, 2022). In neonates, these components represent the first defense mechanism in the prevention of infectious diseases, such as molecules present in the vernix, such as the LL-37 peptide, which directly destroy microorganisms (Dürr et al, 2006).…”

Section: Antimicrobial Peptides and Caseous Vernixmentioning

confidence: 99%

Neonatal innate immunity response in invasive candidiasis

Suárez,

Calumby,

Silva

et al. 2024

Braz. J. Biol.

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Infections caused by Candida spp. are frequent in critically hospitalized patients, especially among premature neonates, representing one of the most common healthcare-related infections. Although there is considerable production of current knowledge about the mechanisms of immune response, aspects involved in the newborn's innate defense are not fully understood. The aim of this study was to describe the innate immune mechanisms involved in the defense of neonates against invasive candidiasis. This is an integrative literature review from the Scopus, Scifinder, Medline, Web of Science databases and the electronic libraries ScienceDirect and Scielo, in the period between 2002 and 2020, with rescue based on primary descriptor Immunity Innate plus secondary descriptors Candidiasis Invasive AND Infant Newborn. We have observed the involvement of various mechanisms in the neonatal response against invasive candidiasis, including the recognition, signaling, recruitment, and initiation of an effective immune response. These mechanisms encompass the presence of antimicrobial peptides, phagocytosis, synthesis of reactive oxygen species, inflammatory mediators, and complex cell signaling systems mediated by Pattern Recognition Receptors (PRRs). With this study, it is expected to contribute to the expansion of knowledge about the immunological mechanisms involved in the innate immune response of the newborn against disseminated infections caused by Candida species, and in the same sense, highlight the importance of this knowledge as a reflex in the decrease in mortality in the neonatal period.

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Section: Antimicrobial Peptides and Caseous Vernixmentioning

confidence: 99%

Neonatal innate immunity response in invasive candidiasis

Suárez,

Calumby,

Silva

et al. 2024

Braz. J. Biol.

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“…The anti-inflammatory activities of iturin compounds have been documented (Figure 2). In the context of wound healing, inflammation plays a crucial role by facilitating the removal of debris and initiating the process of tissue repair [126]. The anti-inflammatory properties of iturin have the potential to assist in the regulation of excessive inflammation and facilitate a harmonized healing process.…”

Section: Wound Healingmentioning

confidence: 99%

Iturin: A Promising Cyclic Lipopeptide with Diverse Applications

Yaraguppi,

Bagewadi,

Patil

et al. 2023

Biomolecules

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This comprehensive review examines iturin, a cyclic lipopeptide originating from Bacillus subtilis and related bacteria. These compounds are structurally diverse and possess potent inhibitory effects against plant disease-causing bacteria and fungi. Notably, Iturin A exhibits strong antifungal properties and low toxicity, making it valuable for bio-pesticides and mycosis treatment. Emerging research reveals additional capabilities, including anticancer and hemolytic features. Iturin finds applications across industries. In food, iturin as a biosurfactant serves beyond surface tension reduction, enhancing emulsions and texture. Biosurfactants are significant in soil remediation, agriculture, wound healing, and sustainability. They also show promise in Microbial Enhanced Oil Recovery (MEOR) in the petroleum industry. The pharmaceutical and cosmetic industries recognize iturin’s diverse properties, such as antibacterial, antifungal, antiviral, anticancer, and anti-obesity effects. Cosmetic applications span emulsification, anti-wrinkle, and antibacterial use. Understanding iturin’s structure, synthesis, and applications gains importance as biosurfactant and lipopeptide research advances. This review focuses on emphasizing iturin’s structural characteristics, production methods, biological effects, and applications across industries. It probes iturin’s antibacterial, antifungal potential, antiviral efficacy, and cancer treatment capabilities. It explores diverse applications in food, petroleum, pharmaceuticals, and cosmetics, considering recent developments, challenges, and prospects.

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“…Hence, there is an urgent need to develop new antimicrobial agents. Antimicrobial peptides (AMPs) are natural immune defense molecules with various unique biological characteristics, including broad-spectrum antimicrobial activity, bactericidal effects, and activity against drug-resistant bacteria [14][15][16][17]. AMPs represent a potential effective alternative [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Exploration of the Antibacterial and Anti-Inflammatory Activity of a Novel Antimicrobial Peptide Brevinin-1BW

Chen,

Wang,

et al. 2024

Molecules

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Antibiotic resistance has emerged as a grave threat to global public health, leading to an increasing number of treatment failures. Antimicrobial peptides (AMPs) are widely regarded as potential substitutes for traditional antibiotics since they are less likely to induce resistance when used. A novel AMP named Brevinin-1BW (FLPLLAGLAASFLPTIFCKISRKC) was obtained by the Research Center of Molecular Medicine of Yunnan Province from the skin of the Pelophylax nigromaculatus. Brevinia-1BW had effective inhibitory effects on Gram-positive bacteria, with a minimum inhibitory concentration (MIC) of 3.125 μg/mL against Enterococcus faecalis (ATCC 29212) and 6.25 μg/mL against both Staphylococcus aureus (ATCC 25923) and multidrug-resistant Staphylococcus aureus (ATCC 29213) but had weaker inhibitory effects on Gram-negative bacteria, with a MIC of ≥100 μg/mL. Studies using scanning electron microscopy (SEM) and flow cytometry have revealed that it exerts its antibacterial activity by disrupting bacterial membranes. Additionally, it possesses strong biofilm inhibitory and eradication activities as well as significant lipopolysaccharide (LPS)-binding activity. Furthermore, Brevinin-1BW has shown a significant anti-inflammatory effect in LPS-treated RAW264.7 cells. In conclusion, Brevinin-1BW is anticipated to be a promising clinical agent with potent anti-Gram-positive bacterial and anti-inflammatory properties.

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Biological Functions and Applications of Antimicrobial Peptides

Cited by 9 publications

References 211 publications

Neonatal innate immunity response in invasive candidiasis

Neonatal innate immunity response in invasive candidiasis

Iturin: A Promising Cyclic Lipopeptide with Diverse Applications

Exploration of the Antibacterial and Anti-Inflammatory Activity of a Novel Antimicrobial Peptide Brevinin-1BW

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