Biological fate of 32P malathion in Gallus domesticus (desi poultry birds)

Gupta, Pawan Kumar; Paul, B. S.

doi:10.1016/0300-483x(77)90062-2

Cited by 3 publications

(4 citation statements)

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“…, 1969; Yadava & Shaw, 1970; Sherman & Herrick, 1971; Pitois et al. , 1973b; Gupta & Paul, 1977; Akhtar & Foster, 1981). While in chickens the majority of an organophosphate dose is generally eliminated in a few days, detectable residues can persist in tissues and eggs for several weeks (March et al.…”

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confidence: 98%

“…phoxim, coumaphos, tetrachlorvinphos, malathion) are potent acetylcholinesterase inhibitors that are applied to poultry houses or individual birds to treat infestations of lice, mites and ticks (Axtell & Arends, 1990; Blagburn & Lindsay, 2001). In chickens and other animals, organphosphates can be absorbed through the skin as well as through the mucous membranes of the eyes, respiratory tract and digestive system (Gupta & Paul, 1977; Abou‐Donia et al. , 1982; Al‐Saleh, 1994).…”

mentioning

confidence: 99%

“…, 1961) (Table 12). The limited available data suggest that in chickens elimination occurs primarily via the urine (Gupta & Paul, 1977). Tetrachlorvinphos residues appear to be more persistent in egg albumen than in yolk (Ivey et al.…”

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confidence: 99%

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Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature

Goetting¹,

Lee²,

Tell³

2011

Journal of Veterinary Pharmacology and Therapeutics

148

135

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Goetting, V., Lee, K. A., Tell, L. A. Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature. J. vet. Pharmacol. Therap.34, 521–556. Poultry treated with pharmaceutical products can produce eggs contaminated with drug residues. Such residues could pose a risk to consumer health. The following is a review of the information available in the literature regarding drug pharmacokinetics in laying hens, and the deposition of drugs into eggs of poultry species, primarily chickens. The available data suggest that, when administered to laying hens, a wide variety of drugs leave detectable residues in eggs laid days to weeks after the cessation of treatment.

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Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature

Goetting¹,

Lee²,

Tell³

2011

Journal of Veterinary Pharmacology and Therapeutics

148

135

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“…No traces of malathion were evident after 3 days, and deposition in fat was not observed. Gupta and Paul (1977) also investigated [ 32 P]malathion residues in hens. Following a single oral dose of 394 mg/kg, liver and kidney radioactivity was significantly decreased after 36 h and virtually absent after 48 h. The residues present in these tissues were characterized from partition experiments as chloroform-soluble (i.e., malathion and maloxon) and water-soluble (i.e., desmethylmalathion and the mono-and dicarboxylic acids of malathion) products.…”

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Characterization of Malathion Residues in Dairy Goats and Poultry

Cannon

Reddy

Murrill

et al. 1996

J. Agric. Food Chem.

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The chemical nature and magnitude of [ 14 C]malathion residues in the milk, eggs (whites and yolks), fat, liver, kidney, and muscle tissues in dairy goats and laying hens were examined after repeated oral exposure. The level and duration of the dose given to goats were equivalent to 86 ppm on feed for 5 days. Chickens received the equivalent of 28 ppm on feed for 4 days. Radioactive residues were characterized and identified using solvent extraction and chromatography. The parent chemical was not detectable, and immediate metabolites of malathion were not present in any tissues except traces of the mono-and dicarboxylic acid metabolites observed in goat kidney. This observation was consistent with urinary excretion as the major elimination pathway of malathion and immediate metabolites in poultry, laboratory animals, and humans. Extensive degradation and metabolism resulted in the reincorporation of the radiolabel into normal biogenic chemicals in all investigated samples. The products were typical of those derived from the tricarboxylic acid cycle. The products included pyruvate, lactate, lactose, oleic acid, stearic acid, and glycerol. Reincorporation of radiolabel into protein was also demonstrated by the isolation and hydrolysis of casein from milk. It was concluded that ingested malathion was converted to acetate or other volatile fatty acids, metabolized to acetyl-CoA, and then incorporated into the carbon pool.

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Kinetic analysis of the fate of methyl parathion in the dog

et al. 1980

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Methyl parathion (1, 3, 10 and 30 mg.kg-1) was injected intravenously in dogs and the serum concentrations were followed in function of time. For each dose the serum level data were fitted to a two- or tri-exponential equation by means of a non-linear least-squares regression analysis computer program. During the first hours after injection a rapid and important decrease of the serum levels was observed, whereas afterwards the levels decreased more slowly with a harmonic mean terminal half-life of 7.2 h (range 6.6-8.8 h) for the 10 mg.kg-1 dose. Simulations using the kinetic parameters obtained for the dose of 10 mg.kg-1 show that elimination of methyl parathion from the body is fast (5 h after injection only 30% of the dose is still present in the body) and that the fraction remaining is mainly located in the peripheral compartments.

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Biological fate of 32P malathion in Gallus domesticus (desi poultry birds)

Cited by 3 publications

References 4 publications

Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature

Pharmacokinetics of veterinary drugs in laying hens and residues in eggs: a review of the literature

Characterization of Malathion Residues in Dairy Goats and Poultry

Kinetic analysis of the fate of methyl parathion in the dog

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