Biological fate of 103Pd in rats following different routes of exposure

Moore, Wellington; Hysell, David K.; Crocker, Walden; Stara, Jerry F.

doi:10.1016/0013-9351(74)90055-3

Cited by 26 publications

(12 citation statements)

References 2 publications

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“…Studies of the distribution of palladium compounds in the tissues of rats, rabbits and dogs after intravenous or intratracheal administration indicated the highest percentage of retention in the kidneys and liver (8-21% of applied dosage), lymphatic nodes, adrenal glands, lungs and bones (37)(38)(39)(40). Also, the retention period in some of the organs was up to 104 days long (37,38).…”

Section: Discussionmentioning

confidence: 99%

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Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Peric¹,

Janković²

2013

Journal of Medical Biochemistry

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SummaryPrevious studies have shown that palladium has toxic effects on the kidney and liver, leads to deterioration of the general condition of animals, and could cause allergy in animals and humans. Considering the limited data about the influence of palladium on the cardiovascular system, the aim of our study was to evaluate the effects of palladium on the heart from available published data, and to compare the toxicity of inorganic and organic palladium compounds. Relevant studies for our review were identified from PubMed and Scopus databases. The search terms included »palladium «, »palladium compound«, »cardiotoxicity«, »toxicity«, »heart«, »myocardium«, »oxidative stress« and »myocardial enzyme«, as well as combinations of these terms. There were only two published studies with the primary purpose to investigate the effect of palladium on the cardiovascular system, while others registered the side-effects of palladium compounds on the heart. Palladium could cause arrhythmias, a drop in blood pressure, decrease of the heart rate, as well as death of experimental animals. Based on the presented data it seems that palladium does not express significant cardiac toxicity when it is bound in an organic compound. Further investigation of the effects of palladium on the heart is necessary for a clear picture of the nature and extent of its cardiac toxicity.

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Section: Discussionmentioning

confidence: 99%

“…Also, the retention period in some of the organs was up to 104 days long (37,38). LD 50 of inorganic palladium compounds for rats, mice and rabbits ranged from 3 mg/kg to 4900 mg/kg (16,38,41).…”

Section: Discussionmentioning

confidence: 99%

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Peric¹,

Janković²

2013

Journal of Medical Biochemistry

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“…Např. pokud jsou ionty palladia podány intravenózně potkanům, ještě 20 % kovu se retinuje po dobu 40 dnů; pokud se stejné množství palladia podá perorálně, 99 % kovu se vyloučí do tří dnů [19]. Rychlost eliminace jednotlivých kovů, obsažených v různých dentálních slitinách, je individuální [9,11].…”

Section: čEskáunclassified

The Assessment of the Biocompatibility of Dental Alloys and Alloys for Dental Amalgam. Part First

Broukal¹,

Fialová²,

Novotný³

2014

Czech Dental Journal

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“…76% after 7 days), only a small proportion is excreted in the faeces. Furthermore, palladium has been shown to be capable of passing the placental barrier [3,4]. Experience with human exposure and information from animal studies is insufficient to enable assignment of a MAK value for palladium [5,6].…”

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confidence: 99%

Palladium [Biomonitoring Methods, 2007]

Angerer¹,

Philippeit²

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Biomonitoring Methods , Vol. 11 (2007) The article contains sections titled: General principles Equipment, chemicals and solutions Equipment Chemicals Solutions Calibration standards Filling and conditioning the SPE columns Specimen collection and sample preparation Sample preparation Operational parameters Operational parameters for high performance liquid chromatography Analytical determination Calibration Calculation of the analytical result Standardisation and quality control Evaluation of the method Precision Accuracy Detection limits Sources of error Discussion of the method

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Biological fate of 103Pd in rats following different routes of exposure

Cited by 26 publications

References 2 publications

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

Cardiotoxicity of Palladium Compounds / Kardiotoksičnost Jedinjenja Paladijuma

The Assessment of the Biocompatibility of Dental Alloys and Alloys for Dental Amalgam. Part First

Palladium [Biomonitoring Methods, 2007]

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