Biological factors that may impair transplacental transfer of RSV antibodies: Implications for maternal immunization policy and research priorities for low- and middle-income countries

Atwell, Jessica E.; Lutz, Chelsea S.; Sparrow, Erin; Feikin, Daniel R.

doi:10.1016/j.vaccine.2022.06.034

Cited by 14 publications

(14 citation statements)

References 101 publications

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“…An expected acquisition of anti-asexual stage Ab was observed during the first two years of life, as previously reported by other studies [ 32 , 47 – 51 ]. The rise in anti-malarial Ab concentrations from 6 to 24 months reveals a progressive immunity acquisition mainly due to repeated exposure to P. falciparum during the first 24 months of life.…”

Section: Discussionsupporting

confidence: 87%

“…Interestingly, peripheral P. falciparum infection during pregnancy was associated with a reduced placental transfer of Abs, as observed in this study. Previous studies reported that high IgG levels, peripheral infections in pregnancy or placental malaria were associated with the low transplacental Ab transfer [ 14 , 45 – 47 ]. Indeed, maternal hypergammaglobulinaemia [ 14 , 45 , 48 ], particularly high IgG cord blood levels may negatively impact on the transplacental transfer of IgG against P. falciparum antigens [ 44 , 49 , 50 ], suggesting a saturation of FcRn receptors,.…”

Section: Discussionmentioning

confidence: 99%

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IgG and IgM responses to the Plasmodium falciparum asexual stage antigens reflect respectively protection against malaria during pregnancy and infanthood

Gbaguidi,

Adamou,

Edslev

et al. 2024

Malar J

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Background Plasmodium falciparum malaria is a public health issue mostly seen in tropical countries. Until now, there is no effective malaria vaccine against antigens specific to the blood-stage of P. falciparum infection. Because the pathogenesis of malarial disease results from blood-stage infection, it is essential to identify the most promising blood-stage vaccine candidate antigens under natural exposure to malaria infection. Methods A cohort of 400 pregnant women and their infants was implemented in South Benin. An active and passive protocol of malaria surveillance was established during pregnancy and infancy to precisely ascertain malaria infections during the follow-up. Twenty-eight antibody (Ab) responses specific to seven malaria candidate vaccine antigens were repeatedly quantified during pregnancy (3 time points) and infancy (6 time points) in order to study the Ab kinetics and their protective role. Abs were quantified by ELISA and logistic, linear and cox-proportional hazard model were performed to analyse the associations between Ab responses and protection against malaria in mothers and infants, taking into account socio-economic factors and for infants an environmental risk of exposure. Results The levels of IgM against MSP1, MSP2 and MSP3 showed an early protective response against the onset of symptomatic malaria infections starting from the 18th month of life, whereas no association was found for IgG responses during infancy. In women, some IgG responses tend to be associated with a protection against malaria risk along pregnancy and at delivery, among them IgG3 against GLURP-R0 and IgG2 against MSP1. Conclusion The main finding suggests that IgM should be considered in vaccine designs during infanthood. Investigation of the functional role played by IgM in malaria protection needs further attention.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

IgG and IgM responses to the Plasmodium falciparum asexual stage antigens reflect respectively protection against malaria during pregnancy and infanthood

Gbaguidi,

Adamou,

Edslev

et al. 2024

Malar J

View full text Add to dashboard Cite

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“…Importantly, our predicted antibody transfer ratios, and subsequent fetal antibody levels at time of birth, are lower than observed in the RSVpreF phase 2b trial (where transfer ratios ranged from 1.41 to 2.10) [18] , leading to more conservative vaccine impact estimates. In order to improve the prediction of the impact of maternal vaccination, especially for preterm infants, and to improve the prediction of the optimal timing of RSV immunization in pregnancy it is essential to have more granular data evaluating the antibody transfer by week of gestational age [32] , [33] .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, for simplicity, and due to a lack of data, we did not incorporate country-specific distributions for age at time of death and gestational age. Our model does not account for comorbidity or other biological factors that may impair antibody transfer, such as low birthweight, maternal HIV infection, and placental malaria [32] , despite their high prevalence in LMICs. We did not incorporate breastfeeding into our model, as research on orally administered antibodies has yielded no significant increase in serum titers of intact antibodies [39] .…”

Section: Discussionmentioning

confidence: 99%

Maternal vaccination against RSV can substantially reduce childhood mortality in low-income and middle-income countries: A mathematical modeling study

Willemsen,

Borghans,

Bont

et al. 2023

Vaccine: X

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“…81 Another condition, hypergammaglobulinemia, which is associated with acute or chronic inflammation, engaged the placental Fcγ receptor with non-specific immunoglobulin and reduced the transfer of disease-specific antibodies. 82,83 Additionally, transplacental IgG transfer is subtype-specific; as IgG1 is preferentially transported compared with IgG2. Protein antigens commonly prompt IgG1, whereas polysaccharide antigens, such as those of pneumococcus, induce IgG2.…”

Section: Immune Protection Through Placentamentioning

confidence: 99%

The protective role of maternal genetic immunization on maternal‐fetal health and welfare

Ahmed,

Jiang,

Liu

et al. 2023

Intl J Gynecology & Obste

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Pregnancy is a critical period associated with alterations in physiologic, biologic, and immunologic processes, which can affect maternal‐fetal health through development of several infectious diseases. At birth, neonates have an immature immune system that makes them more susceptible to severe viral infections and diseases. For this reason, different maternal nutritional and immunization interventions have been used to improve the immune and health status of the mother and her neonate through passive immunity. Here, we reviewed the protective role of maternal immunization with different types of vaccines, especially genetic vaccines, during pregnancy in maternal‐fetal health, immune response, colostrum quality, immune response, and anti‐oxidative status. For this purpose, we have used different scientific databases (PubMed and Google Scholar) and other official web pages. We customized the search period range from the year 2000 to 2023 using the key words “maternal immunization” OR “gestation period/pregnancy” OR “genetic vaccination” OR “maternal‐fetal health” OR “micronutrients” OR “neonatal immunity” “oxidative stress” OR “colostrum quality”. The evidence demonstrated that inactivated or killed vaccines produced significant immune protection in the mother and fetus. Furthermore, most recent studies have suggested that the use of genetic vaccines (mRNA and DNA) during pregnancy is efficient at triggering the immune response in mother and neonate without the risk of undesired pregnancy outcomes. However, factors such as maternal redox balance, nutritional status, and the timing of immunization play essential roles in regulating immune response inflammatory status, antioxidant capacity, and the welfare of both the pregnant mother and her newborn.

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Biological factors that may impair transplacental transfer of RSV antibodies: Implications for maternal immunization policy and research priorities for low- and middle-income countries

Cited by 14 publications

References 101 publications

IgG and IgM responses to the Plasmodium falciparum asexual stage antigens reflect respectively protection against malaria during pregnancy and infanthood

IgG and IgM responses to the Plasmodium falciparum asexual stage antigens reflect respectively protection against malaria during pregnancy and infanthood

Maternal vaccination against RSV can substantially reduce childhood mortality in low-income and middle-income countries: A mathematical modeling study

The protective role of maternal genetic immunization on maternal‐fetal health and welfare

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