Biological Evaluation of Two Estrogenic Steroids as Possible Rodent Chemosterilants

Mischler, Terrence W.; Welaj, P; P, Nemith

doi:10.2307/3799697

Cited by 8 publications

(5 citation statements)

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“…Although the mean litter size decreased in the quinestroltreated gerbils, the ratio of females to males in the litters remained close to 1:1, except in the highest dose group. These findings were similar to those in other reports [27,32]. The restoration of fertility after quinestrol treatment in the Mongolian gerbils has also been observed in rats [27].…”

Section: Discussionsupporting

confidence: 82%

“…These findings were similar to those in other reports [27,32]. The restoration of fertility after quinestrol treatment in the Mongolian gerbils has also been observed in rats [27]. The birth time was prolonged with increasing doses of quinestrol, and there was a significant positive correlation between the birth time and dosage.…”

Section: Discussionsupporting

confidence: 81%

“…A uterine growth-stimulating activity of orally administered estrogenic material has been observed [19,25]. Persistent estrous appeared after quinestrol treatment, and the time to persistent estrous shortened with increasing doses of quinestrol; this finding is consisted with findings in previous investigations [7,8,11,27]. Estrogen has the capacity to produce cornification of vaginal epithelial cells associated with estrous in rodents [12].…”

Section: Discussionsupporting

confidence: 76%

“…Quinestrol has been considered as a possible rodent chemosterilant [27,32]. However, quinestrol activity varies among species based on the dose given and the route of administration.…”

Section: Discussionmentioning

confidence: 99%

“…Quinestrol is a synthetic estrogen with marked estrogenic effects and prolonged activity [10,24,25], and it is an effective contraceptive in women. Additionally, quinestrol has been shown to reduce the fertility of rats [2,11,27]. To our knowledge, the application of quinestrol for fertility control in Mongolian gerbils has not been previously reported, nor have the effects of quinestrol in Mongolian gerbils been studied.…”

Section: Introductionmentioning

confidence: 98%

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The Effects of Quinestrol as a Contraceptive in Mongolian Gerbils (Meriones unguiculatus)

Shi

2011

Exp. Anim.

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Abstract:The contraceptive effects of quinestrol in Mongolian gerbils were examined. The results showed that body weight significantly increased after quinestrol treatment, except in the group that received the highest dose. The gonadosomatic index of ovaries decreased, whereas that of uteri increased, and uterine edema appeared after quinestrol treatment. Histological examination revealed that the ovaries had a lack of mature follicles and corpora lutea and that the myometrium and endometrium of the uteri became thin after quinestrol treatment. Persistent estrous appeared after quinestrol treatment, and time to persistent estrous shortened with increasing doses of quinestrol. Serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels decreased, whereas estradiol (E2) and progesterone (P4) levels increased after quinestrol treatment, and the effects were dose-dependent. During gestation, the serum E2 levels in the different treatment groups were not significantly different. During gestation in the control groups, the serum P4 levels from days 0 to 15 were higher than in the quinestrol-treated groups; however, they did not show significant differences from days 18 to 24. Doses of 0.1 to 2.7 μg/g quinestrol over 6 days completely inhibited fertility. Birth time was prolonged with increasing doses of quinestrol. The findings suggest that quinestrol has marked estrogenic effects in Mongolian gerbils and may inhibit follicle maturation and ovulation through lowered gonadotropin levels. Uterine edema and abnormal E2 and P4 levels during gestation are important causes of pregnancy failure in quinestrol-treated Mongolian gerbils. Quinestrol causes prolonged inhibition of fertility in Mongolian gerbils.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 76%

“…Quinestrol has been considered as a possible rodent chemosterilant [27,32]. However, quinestrol activity varies among species based on the dose given and the route of administration.…”

Section: Discussionmentioning

confidence: 99%