Biological evaluation of secondary metabolites from the roots of Myrica adenophora

Ting, Ya-Chih; Ko, Horng‐Huey; Wang, Hui‐Chun; Peng, Chien‐Fang; Chang, Hsueh‐Wei; Hsieh, Pei‐Chen; Chen, Ih-Sheng

doi:10.1016/j.phytochem.2014.04.003

Cited by 17 publications

(29 citation statements)

References 34 publications

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“…The molecular formula was determined to be C 17 H 24 O 10 CONTACT Yong Zhang zhangyong109@simm.ac.cn; teng Zhang zhangteng501@hotmail.com; Qi Jia q_jia@126.com 1 these authors contributed equally to this work.…”

Section: Resultsmentioning

confidence: 99%

“…Accordingly, the structure of compound 2 was established as myricetin-3,3′,5′-tri-O-α-l-rhamnopyranoside, which was a new flavonol glycosides. The six known compounds were identified as 3,5-dihydroxyphenyl-β-d-glucopyranoside (3) [8], grevilloside F (4) [9], adenodimerin A (5) [10], gallocatechin (6) [11], belamcandol B (7) [12], and 3-methoxy-5-pentadecylphenol (8) [13], by comparison of their spectroscopic data with those reported in the literature, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Two new phenols from Lysimachia patungensis

Gao

Zeng

Jia

et al. 2016

Journal of Asian Natural Products Research

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Two new phenols, methyl 3-(2-O-β-d-glucopyranosyl-3-hydroxy-5-methoxyphenyl) propionate (1) and myricetin-3,3',5'-tri-O-α-l-rhamnopyranoside (2), together with six known phenols compounds (3-8), were isolated from the whole plant of Lysimachia patungensis Hand.-Mazz. Their structures were elucidated on the basis of the interpretation of spectroscopic data, viz., ESI-MS, HR-TOF-MS, UV, IR, and NMR. All the known phenols were isolated from the genus Lysimachia for the first time. A preliminary bioassay revealed that compounds 3 and 7 exhibited significant protective effects against hydrogen peroxide-induced damage in human retinal endothelial cells (HRECs) with the concentration of 10 μM, respectively. Compound 1 showed moderate activity against the HRECs damage at 100 μM.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Two new phenols from Lysimachia patungensis

Gao

Zeng

Jia

et al. 2016

Journal of Asian Natural Products Research

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“…The nitrite measurement was based on our published technique [26]. A cell density of 2 × 10 5 cells/100 μL were seeded into 96-well plates for 24 h. After pre-treating the cells with the compounds, a positive control, aminoguanidine (a selective iNOS inhibitor; 100 μM), or the DMSO (0.1%) vehicle before 200 ng/mL of lipopolysaccharide (LPS) induction.…”

Section: Methodsmentioning

confidence: 99%

Secondary Metabolites of the Endophytic Fungus Lachnum abnorme from Ardisia cornudentata

Chang

Lin

Chen

et al. 2016

IJMS

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Abstract:Fractionation of an EtOAc-soluble fraction of the solid fermentate of an endophytic fungus, Lachnum abnorme Mont. BCRC 09F0006, derived from the endemic plant, Ardisia cornudentata Mez. (Myrsinaceae), resulted in the isolation of three new chromones, lachnochromonins D-F (1-3), one novel compound, lachabnormic acid (4), along with nine known compounds (5-13). Their structures were elucidated by spectroscopic analyses. Alternariol-3,9-dimethyl ether (6) was given the correct data as well as 2D spectral analyses for the first time. This is the first report of the isolation of one unprecedented compound 4 from Lachnum genus, while all known compounds were also found for the first time from Lachnum. The effects of some isolates (3, 4, 7-9, 10, and 13) on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 murine macrophages were also evaluated. Several compounds exhibited weak inhibitory activity on lipopolysaccharide (LPS)-stimulated NO production in RAW 264.7 macrophages.

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“…Following the DPPH assay results, it can be disclosed that the most active compound (2.8-fold more active than ascorbic acid) is adenodimerin A ( 25 ), a new proanthocyanidin type A recently isolated from Morella adenophora roots [ 58 ]. Compound 14 , a myricanol derivative, and compounds 20 , 23 and 26 , flavonoid derivatives, showed DPPH scavenging activity lower than 25 and also lower than α-tocopherol and BHA, other commercially available antioxidant references.…”

Section: Biological Activitiesmentioning

confidence: 99%

“…We were confronted with another difficulty that result from the significantly fluctuating EC 50 values, as an example we can highlight the EC 50 results for compound 12 in two DPPH assays, moreover the authors [ 58 , 62 ] used the same method, only the positive control is different, and this cannot explain the very high variation.…”

Section: Biological Activitiesmentioning

confidence: 99%

Recent Breakthroughs in the Antioxidant and Anti-Inflammatory Effects of Morella and Myrica Species

Silva

Seca

Barreto

et al. 2015

IJMS

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Oxidative stress is one of the risk factors for the development of several chronic diseases, such as diabetes, cancer, cardiovascular and neurodegenerative diseases. Antioxidants are therefore highly sought and can be seen as a type of preventive medicine against several diseases. Myrica and Morella genus (Myricaceae) are taxonomically very close and their species are trees or shrubs with edible fruits that exhibit relevant uses in traditional medicine, for instance in Chinese or Japanese folk medicine they are used to treat diarrhea, digestive problems, headache, burns and skin diseases. Nearly 36 compounds were isolated from different morphological parts of Myrica and/or Morella species and their antioxidant and anti-inflammatory activities evaluated. Thirteen of these compounds exhibit greater effects than the positive controls used. Adenodimerin A was the most active compound reported (in a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay EC50= 7.9 ± 0.3 µM). These results are just one aspect of the antioxidant and anti-inflammatory evaluations reported regarding Myrica and Morella species, so a comprehensive overview on the current status, highlighting the antioxidant health promoting effect of these species, their key antioxidant compounds as well as the compounds with protective effects against oxidative stress related diseases such as inflammation, is relevant.

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Biological evaluation of secondary metabolites from the roots of Myrica adenophora

Cited by 17 publications

References 34 publications

Two new phenols from Lysimachia patungensis

Two new phenols from Lysimachia patungensis

Secondary Metabolites of the Endophytic Fungus Lachnum abnorme from Ardisia cornudentata

Recent Breakthroughs in the Antioxidant and Anti-Inflammatory Effects of Morella and Myrica Species

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