Biological Evaluation of Indole Appended Triazolothiadiazepine Conjugates as Potent Anticancer Agents

Ashitha, Kizhakkan Thiruthi; Salfeena, Chettiyan Thodi F.; Jalaja, Renjitha; Kumar, V Praveen; Rajesab, Parveen; Sasidhar, B. S.

doi:10.2174/1573407213666170707150757

Cited by 2 publications

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“…Hybrid molecules also known as multi‐target compounds have the advantage of affecting diverse biomolecules. Since indole and imidazopyridine scaffolds act as effective biological agents, a hybridization approach was still unexplored by using these two structural modifications [85] . Based on this concept by Bakherad et al [86] .…”

Section: Development Of Various Methods Towards the Synthesis Of Imid...mentioning

confidence: 99%

“…Since indole and imidazopyridine scaffolds act as effective biological agents, a hybridization approach was still unexplored by using these two structural modifications. [85] Based on this concept by Bakherad et al [86] reported the synthesis of imidazopyridine derivatives bearing indole 96 starting from acetophenone and phenyl hydrazine in ethanol and glacial acetic acid in good to excellent yields. Mechanistically, [87] followed by prototropic shift gives the desired product 96 (Scheme 26).…”

Section: Multicomponent Reactionsmentioning

confidence: 99%

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Recent Advances in the Synthesis of Imidazo[1,2‐a]pyridines: A Brief Review

et al. 2022

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This review focuses on providing comprehensive highlights of the recent synthetic pathways of imidazo[1,2‐a]pyridines, assisted through transition metal‐catalyzed reactions, multi‐component reactions, cyclization, condensation, microwave‐assisted reactions, heteroannular and photocatalytic reactions. Among the heterocyclic groups, imidazo[1,2‐a]pyridines are considered as privileged structures because of their occurrence in many natural products. In this review, we have summarized the recent advances in the synthesis of imidazo[1,2‐a]pyridines from 2016 to 2021 from various substrates. This review will provide new initiatives to the chemists towards the synthesis of imidazo[1,2‐a]pyridines and all frequent challenges associated with the reported methods.

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Section: Development Of Various Methods Towards the Synthesis Of Imid...mentioning

confidence: 99%