Biological Evaluation of Essential Oils from Selected Medicinal Plants and Their Main Components against <i>Phytomonas davidi</i> (Kinetoplastea: Trypanosomatidae)

Guzmán, María Fernanda; González-Coloma⊥, Azucena; Andrés, María Fe; Rocha, Juliana Navarro; Martínez-Díaz, Rafael A.

doi:10.1002/cbdv.202000521

Cited by 4 publications

(5 citation statements)

References 33 publications

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“…Among the genus Salvia , the EOs from S. hybrid and S. officinalis showed important antileishmanial effects, while S. blancoana EOs had moderate action against P. davidi . EOs from various species of Salvia have been previously tested on Phytomonas and Leishmania , with moderate effects [ 17 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…EOs from O. majorana and O. dubium have been reported to have antimalarial effects on mice, reducing the parasitemia and increasing their life span [ 57 ]. Also, EOs from O. majorana , O. virens , and O. vulgare have been reported to have anti- Phytomonas effects on P. davidi , with O. virens having the strongest effect [ 22 ]. Other antileishmanial effects were reported from O. virens EO on L. infantum [ 42 ], and O. vulgare EO on L. amazonensis , L. panamensis , and L. braziliensis [ 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

“…Compounds 1 and 2 are common in EOs with activity against promastigotes and amastigotes of L. infantum [ 29 ]. Thymol has been reported to have anti- Phytomonas [ 22 ] and leishmanicidal properties on promastigotes of L. infantum [ 29 ], promastigotes and amastigotes of L. infantum, and amastigotes of L. donovani [ 62 ]. The anti- Leishmania and anti- Phytomonas activities of carvacrol and thymol depend on the presence of the phenolic hydroxyl group, as observed before by Silva et al [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have determined that EOs from plant species belonging to the genera Artemisia [ 21 ], Thymus, Lavandula [ 14 ], Salvia, and Origanum [ 22 ], among others [ 23 ], exhibit antiparasitic properties against multiple protozoa of the kinetoplastida class.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

et al. 2023

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Kinetoplastida is a group of flagellated protozoa characterized by the presence of a kinetoplast, a structure which is part of a large mitochondria and contains DNA. Parasites of this group include genera such as Leishmania, that cause disease in humans and animals, and Phytomonas, that are capable of infecting plants. Due to the lack of treatments, the low efficacy, or the high toxicity of the employed therapeutic agents there is a need to seek potential alternative treatments. In the present work, the antiparasitic activity on Leishmania infantum and Phytomonas davidi of 23 essential oils (EOs) from plants of the Lamiaceae and Asteraceae families, extracted by hydrodistillation (HD) at laboratory scale and steam distillation (SD) in a pilot plant, were evaluated. The chemical compositions of the EOs were determined by gas chromatography-mass spectrometry. Additionally, the cytotoxic activity on mammalian cells of the major components from the most active EOs was evaluated, and their anti-Phytomonas and anti-Leishmania effects analyzed. L. infantum was more sensitive to the EOs than P. davidi. The EOs with the best anti-kinetoplastid activity were S. montana, T. vulgaris, M. suaveolens, and L. luisieri. Steam distillation increased the linalyl acetate, β-caryophyllene, and trans-α-necrodyl acetate contents of the EOs, and decreased the amount of borneol and 1,8 cineol. The major active components of the EOs were tested, with thymol being the strongest anti-Phytomonas compound followed by carvacrol. Our study identified potential treatments against kinetoplastids.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

et al. 2023

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“…EOs with antimalarial properties have been obtained from Hexalobus crispiflorus, Ripia multiflora [40], Ambrosia tenuifolia [41], Artemisia gorgonum [42], Xylopia spp and Artemisia annua [43]. In this study we have evaluated the potential antimalarial activity of EOs from selected chemotypes of Origanum majoricum and Rosmarinus officinalis with reported antioxidant and antiparasitic properties [44][45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Study of Tissue-Specific Reactive Oxygen Species Formation by Cell Membrane Microarrays for the Characterization of Bioactive Compounds

et al. 2021

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The production of reactive oxygen species (ROS) increases considerably in situations of cellular stress, inducing lipid peroxidation and multiple alterations in proteins and nucleic acids. However, sensitivity to oxidative damage varies between organs and tissues depending on the triggering process. Certain drugs used in the treatment of diverse diseases such as malaria have side effects similar to those produced by oxidative damage, although no specific study has been conducted. For this purpose, cell membrane microarrays were developed and the superoxide production evoked by the mitochondrial activity was assayed in the presence of specific inhibitors: rotenone, antimycin A and azide. Once the protocol was set up on cell membrane isolated from rat brain areas, the effect of six antimalarial drugs (atovaquone, quinidine, doxycycline, mefloquine, artemisinin, and tafenoquine) and two essential oils (Rosmarinus officinalis and Origanum majoricum) were evaluated in multiple human samples. The basal activity was different depending on the type of tissue, the liver, jejunum and adrenal gland being the ones with the highest amount of superoxide. The antimalarial drugs studied showed specific behavior according to the type of human tissue analyzed, with atovaquone and quinidine producing the highest percentage of superoxide formation, and doxycycline the lowest. In conclusion, the analysis of superoxide production evaluated in cell membranes of a collection of human tissues allowed for the characterization of the safety profile of these antimalarial drugs against toxicity mediated by oxidative stress.

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Anti-Trichomonas gallinae activity of essential oils and main compounds from Lamiaceae and Asteraceae plants

et al. 2022

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Trichomonas gallinae is a flagellated protozoan that parasitizes the upper digestive tract of various bird species and causes avian trichomonosis. The emergence of resistant strains to the standard treatment, based on nitroimidazoles, increases the need to find alternative therapies. In this study, 36 essential oils (EOs) from Lamiaceae and Asteraceae plant families were tested against T. gallinae trophozoites using the 3-(4,5-dimethylthiazol-2-yl-)-2,5-dipheniltetrazolium bromide (MTT) reduction assay. Among them, EOs from distinct species of Lamiaceae, including the genera Lavandula, Salvia, Thymus, Origanum, and Satureja were the ones reporting better anti-trichomonal activity, and were selected for further analysis, including chemical composition and in vitro assays. The chemical composition of the selected EOs was determined by gas chromatography followed by mass spectrometry and 19 pure compounds were tested against the protozoa, according to their higher abundance in the active EOs. Pure compounds which displayed the highest activity against T. gallinae trophozoites, ordered by highest to lowest activity, were α and β-thujones, camphene, β-pinene, linalyl acetate, thymol, 4-terpineol, γ-terpinene, α-pinene, p-cymene, D-fenchone and β-caryophyllene. A dose dependent effect was observed in most of the EOs and pure compounds tested. The toxicity test conducted in eukaryotic cell cultures with the anti-trichomonal active pure compounds showed that β-caryophyllene, camphene, α-pinene, and β-pinene were slightly toxic for Vero cells, and the selectivity index was calculated. Based on the anti-trichomonal activity and the absence of cytotoxicity results, natural products from Lamiaceae plants could be useful as alternative therapy against avian trichomonosis, mainly those containing linalyl acetate, thymol, 4-terpinenol, γ-terpinene, p-cymene and D-fenchone.

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Biological Evaluation of Essential Oils from Selected Medicinal Plants and Their Main Components against Phytomonas davidi (Kinetoplastea: Trypanosomatidae)

Cited by 4 publications

References 33 publications

Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

Study of Tissue-Specific Reactive Oxygen Species Formation by Cell Membrane Microarrays for the Characterization of Bioactive Compounds

Anti-Trichomonas gallinae activity of essential oils and main compounds from Lamiaceae and Asteraceae plants

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