Biological evaluation of 4,5,7-trisubstituted Indeno[1,2-<em>b</em>]indoles reveals a potent inhibitor of protein kinase CK2 in tumor cells with diverse anti-cancer effects and preferential cytoplasmic localization
Abstract:The highly pleiotropic and constitutively active serine/threonine protein kinase CK2 is considered a key target in cancer. The indeno [1,2-b]indole scaffold was previously shown to provide derivatives exhibiting strong CK2 inhibition and satisfactory drug-like characteristics. In this work, we evaluated one 4,5,7trisubstituted indeno[1,2-b]indole derivative for its intracellular inhibition of CK2 activity and the accompanying effects on proliferation, migration and apoptosis in cancer cells. The compound 5-iso… Show more
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