2017
DOI: 10.1016/j.intimp.2016.12.009
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Biological evaluation and molecular docking studies of nitro benzamide derivatives with respect to in vitro anti-inflammatory activity

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Cited by 27 publications
(19 citation statements)
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“…Normally, this highly regulated and self-limiting phenomenon promotes the healing process. However, uncontrolled and pro-longed process, called as chronic inflammation, may cause sustained activation of immune cells resulted in high amount of cytokine release [344,345]. This persistent response potentially leads to pathological disorders such as autoimmune diseases, diabetes, heart diseases, cancer and various neurodegenerative disorders.…”
Section: Biological Activities Piper Plantsmentioning
confidence: 99%
“…Normally, this highly regulated and self-limiting phenomenon promotes the healing process. However, uncontrolled and pro-longed process, called as chronic inflammation, may cause sustained activation of immune cells resulted in high amount of cytokine release [344,345]. This persistent response potentially leads to pathological disorders such as autoimmune diseases, diabetes, heart diseases, cancer and various neurodegenerative disorders.…”
Section: Biological Activities Piper Plantsmentioning
confidence: 99%
“…1). 25,26 Once the 4-(nitrophenyl)hydrazone derivatives of N-acylhydrazone were designed, an efficient synthetic route was implemented on the grounds of the problem's retrosynthetic analysis (Scheme 1), leading to a series of novel compounds, which was studied by screening substituents attached to the aryl ring located near to the acyl group (Scheme 2). A set of para-substituents was selected by physical-chemical criteria: r p -Hammett constant, ranging from À0.83 for N,N-dimethylamino to +0.78 for nitro, lipophilicity and hydrogen bond acceptor/donor, allowing us to study the substituent effect on the activity.…”
Section: Introductionmentioning
confidence: 99%
“…The effects of GR24 (5, 10, 20, 50, 100 μM) on cell viability were determined using the MTT assay as described previously …”
Section: Methodsmentioning
confidence: 99%