Biological entities as chemical reactors for synthesis of nanomaterials: Progress, challenges and future perspective

Hasan, Murtaza; Ullah, Ihsan; Zulfiqar, Hina; Naeem, Komal; Iqbal, Arfa; Gul, Huma; Ashfaq, Muhammad; Mahmood, Nasir

doi:10.1016/j.mtchem.2018.02.003

Cited by 132 publications

(60 citation statements)

References 123 publications

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“…However, the majority of those methods are expensive and create a potential risk to the environment and organisms. In this decade, the focus on obtaining eco-friendly products in eco-friendly ways is increasing, and we are trying to find alternative solutions (Hasan et al 2018). One example of that is the biological synthesis of metal nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Biologically synthesized of Au/Pt/ZnO nanoparticles using Arctium lappa extract and cytotoxic activity against leukemia

Dobrucka

Romaniuk-Drapała

Kaczmarek

2020

Biomed Microdevices

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The main objective of this work was to assess the cytotoxic activity of Au/Pt/ZnO nanoparticles synthesized using Arctium lappa extract against leukemia. The Au/Pt/ZnO nanoparticles obtained as a result of biological synthesis were characterized by UV-Vis, Scanning (SEM) and Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and Atomic Force Microscopy (AFM). The applied methods showed that the size of nanoparticles ranged from 10 to 40 nm. This work also assessed the cytotoxicity of Au/Pt/ZnO nanoparticles by means of MTT assay, and analyzed apoptosis as well as the influence of the cultivation time and concentration of Au/Pt/ZnO nanoparticles on the percentage of dead cells. The studies showed that the percentage of dead leukemia cells increased with the cultivation time and concentration of Au/Pt/ZnO nanoparticles. There was observed an increase in the percentage of cells in the G2/M phase, which suggests the stoppage of G2/M leading to cell death. The cytotoxicity of Au/Pt/ZnO nanoparticles determined by means of the MTT test indicated that the viability of leukemia cells practically disappeared when the concentration of the tested nanoparticles was 10 mol.

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Section: Introductionmentioning

confidence: 99%

Biologically synthesized of Au/Pt/ZnO nanoparticles using Arctium lappa extract and cytotoxic activity against leukemia

Dobrucka

Romaniuk-Drapała

Kaczmarek

2020

Biomed Microdevices

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“…Recently, there have been many reports on synthesis of Ag NPs by using root, leaf and stem extracts of plants such as Dracaena cochinchinensis, Eucommia ulmoides, Gloriosa superba, Raphanus sativus and Sargassum polycystum. [6][7][8][9][10][11] These biological entities have bioactive compounds in their extracts which have the ability to reduce metal ions into atoms, which results in nuclei that consequently provide a base for a variety of nanomaterials. For example, Hu et al investigated that conversion of Ag ions to Ag NPs and their size distribution is totally dependent on the concentration of lignin which serves as the reducing and capping agent.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of silver nanoparticles using Fagonia cretica and their antimicrobial activities

et al. 2019

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“…Tian et al biofabricated the selenium-containing nanoparticles in Shewanella oneidensis MR-1 cells using an extracellular electron transfer regulation strategy [40]. Bacteria, as one of the most important living organisms, are considered as the optimal bioreducing nanofactories due to their simple culturing conditions and rapid propagation [41]. However, there has been almost no research on the bacterium-biosynthesized manganese-(Mn-) containing nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Template Synthesis of Multifunctional Nanospindles for Glutathione Detection and Enhanced Cancer-Specific Chemo-Chemodynamic Therapy

et al. 2020

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Biological synthetic methods of nanoparticles have shown great advantages, such as environmental friendliness, low cost, mild reaction conditions, and enhanced biocompatibility and stability of products. Bacteria, as one of the most important living organisms, have been utilized as bioreducing nanofactories to biosynthesize many metal nanoparticles or compounds. Here, inspired by the disinfection process of KMnO4, we for the first time introduce bacteria as both the template and the reducing agent to construct a novel tumor microenvironment-responsive MnOx-based nanoplatform for biomedical applications in various aspects. It is found that the bacterium/MnOx-based nanospindles (EM NSs) can efficiently encapsulate the chemotherapeutic agent doxorubicin (DOX), leading to the fluorescence quenching of the drug. The as-formed DOX-loaded EM NSs (EMD NSs) are proven to be decomposed by glutathione (GSH) and can simultaneously release DOX and Mn2+ ions. The former can be utilized for sensitive fluorescence-based GSH sensing with a limit of detection as low as 0.28 μM and selective cancer therapy, while the latter plays important roles in GSH-activated magnetic resonance imaging and chemodynamic therapy. We also demonstrate that these nanospindles can generate oxygen in the presence of endogenous hydrogen peroxide to inhibit P-glycoprotein expression under hypoxia and can achieve excellent tumor eradication and tumor metastasis inhibition performance. Taken together, this work designs a multifunctional bacterially synthesized nanomissile for imaging-guided tumor-specific chemo-chemodynamic combination therapy and will have implications for the design of microorganism-derived smart nanomedicines.

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Biological entities as chemical reactors for synthesis of nanomaterials: Progress, challenges and future perspective

Cited by 132 publications

References 123 publications

Biologically synthesized of Au/Pt/ZnO nanoparticles using Arctium lappa extract and cytotoxic activity against leukemia

Biologically synthesized of Au/Pt/ZnO nanoparticles using Arctium lappa extract and cytotoxic activity against leukemia

Synthesis of silver nanoparticles using Fagonia cretica and their antimicrobial activities

Bacterial Template Synthesis of Multifunctional Nanospindles for Glutathione Detection and Enhanced Cancer-Specific Chemo-Chemodynamic Therapy

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