Biological efficacy and absorption of DL‐methionine hydroxy analogue free acid compared to DL‐methionine in chickens as affected by heat stress

Rostagno, H. S.; Barbosa, W. A.

doi:10.1080/00071669508417777

Cited by 44 publications

(20 citation statements)

References 10 publications

(19 reference statements)

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“…Dietary methionine supplementation is usually provided using chemically synthesized DL-methionine (DL-Met) or one of its hydroxy analogues, for example, DL-2-hydroxy-(4-methylthio) butanoic acid (DL-HMTBA). Research in this field has mainly concerned the respective use of these products, giving relatively controversial results [9,[12][13][14][15][16][17]. This is, in part, due to differences in the experimental conditions used, but differences in intake, intestinal absorption and metabolic conversion to L-methionine have been evoked as confounding factors.…”

Section: General Effects Of Sulfur Amino Acidsmentioning

confidence: 99%

Mechanisms through which sulfur amino acids control protein metabolism and oxidative status

Métayer¹,

Seiliez²,

Collin³

et al. 2008

The Journal of Nutritional Biochemistry

228

151

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Section: General Effects Of Sulfur Amino Acidsmentioning

confidence: 99%

Mechanisms through which sulfur amino acids control protein metabolism and oxidative status

Métayer¹,

Seiliez²,

Collin³

et al. 2008

The Journal of Nutritional Biochemistry

228

151

View full text Add to dashboard Cite

“…In the literature, there is a vivid and controversial discussion concerning the relative biological efficiency of MHA-FA and DLM (e.g., Huyghebaert, 1993;Rostagno and Barbosa, 1995;Schutte and De Jong, 1996). Both methionine sources allow for accurate balancing of the dietary amino acid profile; however, information about the relative bio-logical efficiency of MHA-FA compared with DLM is a relevant factor for cost-effective purchasing, feed formulation, and animal production.…”

Section: Introductionmentioning

confidence: 99%

Meta-Analysis of the Relative Efficiency of Methionine-Hydroxy-Analogue-Free-Acid Compared with dl-Methionine in Broilers Using Nonlinear Mixed Models

et al. 2008

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The purpose of this paper was to perform a meta-analysis to compare the biological efficiency of DL-methionine with methionine-hydroxy-analogue-free-acid in broiler chickens. A database was developed which contained dose-response studies of these 2 methionine sources. Criteria for entry into the database were defined before the meta-analysis was initiated. Data from 46 dose-response experiments, extracted from a total of 27 peer-reviewed papers, were used for the analysis with the Statistical Analysis System. Initially, the NLIN procedure was applied to fit an exponential model of the form y = alpha + beta*[1 - exp (-Gamma*dose)] + e. Thereafter, meta-analysis was conducted by means of nonlinear mixed models, which were fitted by a full maximum likelihood method as implemented in the NLMIXED procedure. The nonlinear model used for the analysis allowed for separate plateaus or different efficiencies of the methionine sources. Mixed modeling was applied to account for heterogeneity among the studies in all regression parameters for both sources of methionine via random effects. Statistical hypotheses were tested by the asymptotic Wald test. In addition, potential co-variables were tested for inclusion as linear regressors for the nonlinear model parameters. In conclusion, the null hypothesis of equal plateaus of the 2 methionine sources was not rejected. The analyses of the response variables average daily gain (ADG) and gain to feed ratio (GF) showed a highly significant difference between the tested methionine sources. The covariate age at start of experiment significantly affected the intercept term alpha for the response variables ADG and GF, respectively. The meta-analysis showed that biological efficiencies of DL-methionine-hydroxy-analogue-free-acid were 81 and 79% of the values for DL-methionine, on an equimolar basis, for ADG and GF, respectively.

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“…Effects of dietary treatments on crude protein and ether extract of broilers' meat may be due to the role played by methionine in protein synthesis in broilers (NRC, 1984) and high protein content of groundnut cake which is the main test ingredient as reported by Rostagno and Barbosa, (1995). Groundnut cake was reported to contain high level of edible oil (Atasie et al, 2009) and this might be responsible for significant dietary effect of treatments on ether extract of broilers' meat.…”

Section: Discussionmentioning

confidence: 99%

Meat and Bone Characteristics of Broiler Chickens Fed Groundnut Cake-Based Diets as Affected by Graded Dietary Supplements of Crystalline L- Lysine and DL- Methionine

Ogunwole

Majekodunmi

Faboyede

et al. 2016

JAA

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I S S N 2 3 4 9 -0 8 3 7 V o l u m e 6 N u m b e r 1 J o u r n a l o f A d v a n c e s i n A g r i c u l t u r e ABSTRACTEffects of supplemental L-lysine and DL-methionine in a Groundnut Cake (GNC) based diets on meat and bone characteristics of broiler chickens were investigated. In a completely randomized design, a total of 168 one -day -old Arbor acre broiler chicks were randomly allocated to seven dietary treatments each in triplicate of eight birds per replicate. The seven starter and finishers' diets were: GNC based diets without any amino acid (L-lysine or DL-methionine) supplementation (T1); GNC diet + 0.2% L-lysine (T2); GNC diet + 0.4% L-lysine (T3); GNC diet + 0.2% DL-methionine (T4); GNC diet + 0.4% DL-methionine (T5); GNC diet + 0.2 L-lysine and 0.2% DL-methionine (T6) and GNC diet + 0.4% Llysine and 0.4% DL-methionine (T7). Experimental diets and water were offered to birds ad libitum in an experiment lasting six-week. At day 42, two birds per replicate were slaughtered, meat and bone characteristics determined. There were significant variations (P<0.05) in the crude protein (%) and ether extract (%), pH1 and pH2 of meat. Thiobarbituric acid reactive substances composition of meat at days 0, 5, and 10 were similar (P<0.05) and were not affected by dietary amino acid supplementation. Tibiotarsal index (mg/mm) of bone (22.10, 27.25, 33.35, 31.40, 28.70, 31.45 and 29.75 for broilers on T1, T2, T3, T4, T5, T6 and T7, respectively) was increased significantly (P<0.05) by amino acid supplementation. Significantly differences (P<0.05) were observed in the calcium, phosphorus and potassium (%) contents of broilers' bone across treatments. Supplemental L-lysine as well as both L-lysine and DL-methionine improved meat quality and bone development of broiler chickens in this study.

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Biological efficacy and absorption of DL‐methionine hydroxy analogue free acid compared to DL‐methionine in chickens as affected by heat stress

Cited by 44 publications

References 10 publications

Mechanisms through which sulfur amino acids control protein metabolism and oxidative status

Mechanisms through which sulfur amino acids control protein metabolism and oxidative status

Meta-Analysis of the Relative Efficiency of Methionine-Hydroxy-Analogue-Free-Acid Compared with dl-Methionine in Broilers Using Nonlinear Mixed Models

Meat and Bone Characteristics of Broiler Chickens Fed Groundnut Cake-Based Diets as Affected by Graded Dietary Supplements of Crystalline L- Lysine and DL- Methionine

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