Biological effects of Myristica fragrans (nutmeg) extract

Olajide, Olumayokun A.; Ajayi, Franklin F.; Ekhelar, A I; Awe, S. O.; Makinde, J. M.; Alada, A R A

doi:10.1002/(sici)1099-1573(199906)13:4<344::aid-ptr436>3.0.co;2-e

Cited by 96 publications

(44 citation statements)

References 4 publications

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“…(Myristicaceae) has played an important role in traditional medicine of some countries for the cure of stomach disorders (Mahady et al, 2005). The essential oil of M. fragrans is used for rheumatism, and as a carminative and postpartum medication (Olajide et al, 1999). The results of the in vitro screening of methanol extracts of 24 plant species, which have a history of traditional use in the treatment of gastrointestinal disorders, against 15 strains of H. pylori, revealed that the most active extracts were those of M. fragrans with an MIC of 12.5 mg/mL (Mahady et al, 2005).…”

Section: Myristica Fragransmentioning

confidence: 99%

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Safavi

Shams-Ardakani

Foroumadi

2014

Pharmaceutical Biology

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Context: Helicobacter pylori is a small, spiral, Gram-negative bacillus that plays a role in the pathogenesis of a number of diseases ranging from asymptomatic gastritis to gastric cancer. Schedule compliance, antibiotic drug resistance, and side-effects of triple or quadruple therapy have led to research for novel candidates from plants.Objective: The purpose of this paper is to review the most potent medicinal plants of recently published literature with anti-H. pylori activity. For centuries, herbals have been used by traditional healers around the world to treat various gastrointestinal tract disorders such as dyspepsia, gastritis, and peptic ulcer disease. The mechanism of action by which these botanicals exert their therapeutic properties has not been completely and clearly elucidated. Anti-H. pylori properties may be one of the possible mechanisms by which gastroprotective herbs treat gastrointestinal tract disorders. Materials and methods: Electronic databases such as PubMed, Google scholar, EBSCO, and local databases were explored for medicinal plants with anti-H. pylori properties between 1984 and 2013 using key words ''medicinal plants'' and ''Helicobacter pylori'' or ''anti-Helicobacter pylori''. Results: A total of 43 medicinal plant species belonging to 27 families including Amaryllidaceae,

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Section: Myristica Fragransmentioning

confidence: 99%

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Safavi

Shams-Ardakani

Foroumadi

2014

Pharmaceutical Biology

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“…12) Its fruit, commonly known as mace (outer husk) or nutmeg (inner seed or kernel), has been used traditionally as spice and also possesses carminative, astringent, hypolipidemic, antithrombotic, antiplatelet aggregation, antifungal, aphrodisiac, anxiogenic, antidiarrheal, and antiinflammatory activities. [13][14][15] Macelignan isolated from M. fragrans belongs to the lignan constituents, 16) and has been reported to have a broad spectrum of biological activities such as antioxidant, antiinflammatory, anticarinogenic, and hepatoprotective effects and cause alteration in hepatic enzyme activities. [17][18][19][20][21] However, the effects of macelignan on melanogenesis have not been examined so far.…”

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confidence: 99%

Inhibitory Effects of Macelignan Isolated from Myristica fragrans HOUTT. on Melanin Biosynthesis

Cho

Kim

Shim

et al. 2008

Biological & Pharmaceutical Bulletin

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The aim of this study was to investigate the in vitro inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in melan-a murine melanocytes. The IC 50 values of macelignan for melanogenesis and tyrosinase were 13 m mM and 30 m mM, respectively, while those of arbutin as a positive control were 990 m mM and 660 m mM, respectively. In Western blot analysis, macelignan also significantly decreased tyrosinase, TRP-1, and TRP-2 protein expression. These results indicate that macelignan effectively inhibits melanin biosynthesis and thus could be employed as a new skin-whitening agent.

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“…is a plant cultivated in Indonesia, South Africa, India, and other tropical areas. Nutmeg has traditionally been used as a spice, but also possesses bioactive properties including carminative, astringent, hypolipidemic, antithrombotic, antiplatelet aggregation, antifungal, aphrodisiac, anxiogenic, antidiarrheal, and antiinflammatory activities (9). In addition, studies have reported that macelignan, a major bioactive compound of nutmeg, exerts antioxidant, antibacterial, and anti-inflammatory actions (10,11).…”

Section: Introductionmentioning

confidence: 92%

Effect of oral administration of nutmeg extract on american house dust mite (Dermatophagoides farinae) extract-induced atopic dermatitis-like skin lesions in NC/Nga mice

Chung

Kim

Mun

et al. 2012

Food Sci Biotechnol

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The effects of oral administration of nutmeg extract (NE) on atopic dermatitis (AD) were evaluated using NC/Nga mice treated with American house dust mite (Dermatophagoides farinae) extract. In this mouse model of AD, NE suppressed transepidermal water loss, erythema, and the production of serum immunoglobulin E, interleukin (IL)-4, and interferon-γ by auxillary lymph node cells. In addition, NE reduced epidermal thickening and inflammatory cell infiltration into the skin. In skin lesions, NE suppressed IL-13 and tumor necrosis factor (TNF)-α mRNA expression. In the spleen, NE upregulated T-box transcription factor expressed in T cells and downregulated GATA-binding protein 3, which are involved in T helper cell differentiation. Our findings suggest that NE ameliorates AD and may be a potential nutraceutical candidate for treating AD.

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Biological effects of Myristica fragrans (nutmeg) extract

Cited by 96 publications

References 4 publications

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Inhibitory Effects of Macelignan Isolated from Myristica fragrans HOUTT. on Melanin Biosynthesis

Effect of oral administration of nutmeg extract on american house dust mite (Dermatophagoides farinae) extract-induced atopic dermatitis-like skin lesions in NC/Nga mice

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