Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects

Krajnak, Kristine; Kan, Hong; Russ, Kristen A.; McKinney, Walter; Waugh, Stacey; Zheng, Weihui; Kashon, Michael L.; Johnson, Claud; Cumpston, Jared L.; Fedan, Jeffrey S.

doi:10.1016/j.taap.2020.115242

Cited by 13 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When dust is inhaled by the body, it not only accumulates in the lungs, but also enters the circulation through the blood barrier and damages other organs [39]. This has been confirmed by many animal tests [40,41]. It is, therefore, speculated that the increased risk of hyperuricemia development from dust exposure may be owing to kidney damage, which affects the normal metabolism of purines and the normal excretion of uric acid, leading to an elevation in uric acid levels in the blood.…”

Section: Discussionmentioning

confidence: 79%

Influence of occupational exposure on hyperuricemia in steelworkers: a nested case–control study

et al. 2022

View full text Add to dashboard Cite

Background Occupational exposure may be associated with an increased risk of developing hyperuricemia. This study sheds lights on the association between occupational exposure and hyperuricemia in steelworkers. Method A nested case–control study was conducted within a cohort of workers in steel companies to explore the association between occupational exposure and hyperuricemia. The case group consisted of a total of 641 cases of hyperuricemia identified during the study period, while 641 non-hyperuricemia subjects with the same age and gender distribution were randomly selected from the cohort as the control group. Results The incidence rate of hyperuricemia among workers in the steel company was 17.30%, with an incidence density of 81.32/1,000 person-years. In comparison to the reference group, the risks of developing hyperuricemia for steelworkers undergoing ever shifts, current shifts, heat exposure, and dust exposure were 2.18 times, 1.81 times, 1.58 times and 1.34 times higher respectively. The odds ratios (ORs) and 95% confidence intervals (CIs) were 1.87(1.12–3.13) and 2.02(1.21–3.37) for the cumulative number of days of night work at 0–1,972.80 and ≥ 1,972.80 (days), respectively. Compared to the group with the cumulative heat exposure of 0 (°C/year), the ORs (95% CI) for the risk of developing hyperuricemia in the groups with the cumulative heat exposure of 0–567.83 and ≥ 567.83 (°C/year) were 1.50(1.02–2.22) and 1.64(1.11–2.43), respectively. The OR (95% CI) for the risk of developing hyperuricemia was 1.56(1.05–2.32) at the cumulative dust exposure of ≥ 30.02 (mg/m3/year) compared to that at the cumulative dust exposure of 0 (mg/m3/year). Furthermore, there was a multiplicative interaction between heat exposure and dust exposure in the development of hyperuricemia. Conclusion Shift work, heat, and dust are independent risk factors for the development of hyperuricemia in steelworkers. Additionally, there is a multiplicative interaction between heat exposure and dust exposure in the development of hyperuricemia. Interventions for shift work, heat and dust may help to reduce the incidence rate of hyperuricemia and improve the health of steelworkers.

show abstract

Section: Discussionmentioning

confidence: 79%

Influence of occupational exposure on hyperuricemia in steelworkers: a nested case–control study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Does fracking induce a higher risk of stroke? Although a potential connection between fracking and stroke has been mentioned in the literature (e.g., [ 35 , 36 , 37 ]), there is no systematic study to address this question. The closest research to this work is the study on the impact of fracking on water pollution [ 38 ] and air pollution [ 39 ], but its research data are limited to the local area.…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal Correlation Analysis of Hydraulic Fracturing and Stroke in the United States

Liu

Wang

et al. 2022

IJERPH

View full text Add to dashboard Cite

Hydraulic fracturing or fracking has led to a rapid growth of oil and gas production in the United States, but the impact of fracking on public health is an important but underresearched topic. We designed a methodology to study spatiotemporal correlations between the risk of fracking and stroke mortality. An annualized loss expectancy (ALE) model is applied to quantify the risk of fracking. The geographically and temporally weighted regression (GTWR) model is used to analyze spatiotemporal correlations of stroke mortality, fracking ALE, and nine other socioeconomic- and health-related factors. The analysis shows that fracking ALE is moderately correlated with stroke mortality at ages over 65 in most states of fracking, in addition to cardiovascular disease and drug overdose being positively correlated with stroke mortality. Furthermore, the correlations between fracking ALE and stroke mortality in men appear to be higher than in women near the Marcellus Shale, including Ohio, Pennsylvania, West Virginia, and Virginia, while stroke mortality among women is concentrated in the Great Plains, including Montana, Wyoming, New Mexico, and Oklahoma. Lastly, within two kilometers of the fracking mining activity, the level of benzene in the air was found to be significantly correlated with the fracking activity in Colorado.

show abstract

Biological effects of inhaled hydraulic fracturing sand dust. VIII. Immunotoxicity

Anderson

Shane

Long

et al. 2020

Toxicology and Applied Pharmacology

Self Cite

View full text Add to dashboard Cite

Hydraulic fracturing ("fracking") is a process used to enhance retrieval of gas from subterranean natural gasladen rock by fracturing it under pressure. Sand used to stabilize fissures and facilitate gas flow creates a potential occupational hazard from respirable fracking sand dust (FSD). As studies of the immunotoxicity of FSD are lacking, the effects of whole-body inhalation (6 h/d for 4 d) of a FSD, i.e., FSD 8, was investigated at 1, 7, and 27 d post-exposure in rats. Exposure to 10 mg/m 3 FSD 8 resulted in decreased lung-associated lymph node (LLN) cellularity, total B-cells, CD4+ T-cells, CD8+ T-cells and total natural killer (NK) cells at 7-d post exposure. The frequency of CD4+ T-cells decreased while the frequency of B-cells increased (7 and 27 d) in the LLN. In contrast, increases in LLN cellularity and increases in total CD4+ and CD8+ T-cells were observed in rats following 30 mg/m 3 FSD 8 at 1 d post-exposure. Increases in the frequency and number of CD4+ T-cells and NK cells were observed in bronchial alveolar lavage fluid at 7-d post-exposure (10 mg/m 3 ) along with an increase in total CD4+ T-cells, CD11b + cells, and NK cells at 1-day post-exposure (30 mg/m 3 ). Increases in the numbers of B-cells and CD8+ T-cells were observed in the spleen at 1-day post 30 mg/m 3 FSD 8 exposure. In addition, NK cell activity was suppressed at 1 d (30 mg/m 3 ) and 27 d post-exposure (10 mg/m 3 ). No change in the IgM response to sheep red blood cells was observed. The findings indicate that FSD 8 caused alterations in cellularity, phenotypic subsets, and impairment of immune function.

show abstract

Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects

Cited by 13 publications

References 32 publications

Influence of occupational exposure on hyperuricemia in steelworkers: a nested case–control study

Influence of occupational exposure on hyperuricemia in steelworkers: a nested case–control study

Spatiotemporal Correlation Analysis of Hydraulic Fracturing and Stroke in the United States

Biological effects of inhaled hydraulic fracturing sand dust. VIII. Immunotoxicity

Contact Info

Product

Resources

About