Biological Effects of Dried and Extracted Goldenberry on Diabetic Rats

Abstract

The objective of this study is to investigate the biological effects of dried goldenberry and its extracted on diabetic rats. Biological assay was conducted on diabetic mal-rats. The results indicated that supplementation with extract or dried goldenberry showed improve in relative organ weights (liver, heart, kidney, spleen, lungs and pancreas) and a significant increase in weight gain, food intake and food efficiency ratio. Serum blood glucose was significantly reduced in diabetic groups treated with extract or dried goldenberry at the end of experiment. This decrease was ranged from 98.33 mg/dl (G4) to 113.67 mg/dl (G5) as compared to positive control (204.33 mg/dl). The group fed on ethanolic goldenberry extract 500 mg\kg b.wt (G4) reported highest decrease in total cholesterol, triglycerides and LDL-C by means 90.67, 97.33 and 28.2 mg/dl, respectively and highest increase in HDLc by mean 43 mg/dl in the same group as compared to positive control. On other hand, no significant (P>0.01) difference was found in uric acid, urea and creatinine values between negative control group and all treated groups except urea value of group fed on 10% dried goldenberry (G5). While, group that feed on extract or dried goldenberry had lower (P≤0.01) ALT, AST and ALP activities than positive control rats by different rates. Furthermore, The best effect was for group fed on ethanolic goldenberry extract 500 mg\kg b.wt (G4) followed by group fed on 15% dried goldenberry (G6). While, the lowest effect was for group fed on 10% dried goldenberry (G5) but still higher than the value of negative control group (G1). So we found goldenberry could be has therapeutic effect for diabetes and considered as a new source of bioactive and functional food.

Chemical and Biological Studies on the Goldenberry (Physalis peruviana L.) on Hyperglycemic Rats

“…Indicated that TC, triglycerides, LDL-c cholesterol and VLDL-c in the groups G3, and G4 of rats that fed on basal diet supplemented with golden berry decreased, while HDL-c cholesterol increased compared to diabetic control rats (G2). These results are agreeing with [38]. Goldenberry improve the lipid profile of rats with high lipid levels when fed goldenberry.…”