Biological Effects of Cold Atmospheric Pressure Plasma on Skin Cancer

Terefinko, Dominik; Dzimitrowicz, Anna; Bielawska‐Pohl, Aleksandra; Klimczak, Aleksandra; Pohl, Paweł

doi:10.1007/s11090-020-10150-7

Cited by 10 publications

(5 citation statements)

References 55 publications

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“…With regard to cancer treatment, various strategies using different types of CAPs have recently shown promising effects in cellular tumor models of breast cancer 12 – 14 , cervical cancer 13 – 15 , liver cancer 16 , lung cancer 17 , skin cancer 18 – 22 , and other cancers 6 , 8 . Numerous therapeutic advantages of CAPs over treatments with conventional chemotherapeutic agents have been identified as a result of previous studies, the most important being probably the selective effect of cold plasma on normal and carcinoma cells 22 – 24 .…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of cold atmospheric pressure plasma and free or liposomal doxorubicin on melanoma cells

Pefani-Antimisiari

Athanasopoulos

Marazioti

et al. 2021

Sci Rep

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The aim of the present study was to investigate combined effects of cold atmospheric plasma (CAP) and the chemotherapeutic drug doxorubicin (DOX) on murine and human melanoma cells, and normal cells. In addition to free drug, the combination of CAP with a liposomal drug (DOX-LIP) was also studied for the first time. Thiazolyl blue tetrazolium bromide (MTT) and Trypan Blue exclusion assays were used to evaluate cell viability; the mechanism of cell death was evaluated by flow cytometry. Combined treatment effects on the clonogenic capability of melanoma cells, was also tested with soft agar colony formation assay. Furthermore the effect of CAP on the cellular uptake of DOX or DOX-LIP was examined. Results showed a strong synergistic effect of CAP and DOX or DOX-LIP on selectively decreasing cell viability of melanoma cells. CAP accelerated the apoptotic effect of DOX (or DOX-LIP) and dramatically reduced the aggressiveness of melanoma cells, as the combination treatment significantly decreased their anchorage independent growth. Moreover, CAP did not result in increased cellular uptake of DOX under the present experimental conditions. In conclusion, CAP facilitates DOX cytotoxic effects on melanoma cells, and affects their metastatic potential by reducing their clonogenicity, as shown for the first time.

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Section: Introductionmentioning

confidence: 99%

Synergistic effect of cold atmospheric pressure plasma and free or liposomal doxorubicin on melanoma cells

Pefani-Antimisiari

Athanasopoulos

Marazioti

et al. 2021

Sci Rep

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“…[36][37][38][39][40] Furthermore, studies have been conducted in the literature on the anticancer efficacy of CAP on several types of skin cancer. [41] Cutaneous SCC is a type of skin cancer caused by DNA damage because of prolonged exposure to UV radiation. Due to changes in the ozone layer, the incidence of SCC has grown by 200% over the past three decades, and it is predicted that this rate will continue to increase over time.…”

Section: Discussionmentioning

confidence: 99%

Effect of direct plasma treatment and plasma‐treated liquid on cutaneous squamous cell carcinoma: A proof‐of‐concept study

Özdemir

Ercan

Karaman

et al. 2023

Plasma Processes & Polymers

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This study investigates the efficacy of cold atmospheric plasma (CAP) in treating squamous cell carcinoma (SCC), a highly metastatic cancer. To assess the anticancer activity, two CAP treatment methods—direct treatment and indirect treatment (plasma‐treated N‐acetyl cysteine solution)—were used. Results indicate that both methods selectively target SCC cells, inducing oxidative and nitrosative stress, leading to decreased metabolic activity and increased apoptosis. Furthermore, a critical feature of cancer cells, metastatic behavior is also inhibited by CAP treatment. Coculture experiments demonstrate the effectiveness of CAP treatment in selectively inactivating SCC cells while leaving healthy cells unaffected. These findings suggest the potential use of CAP as a selective and effective treatment for SCC.

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“…[ 1–3 ] For example, it has been proved that the reactive oxygen and nitrogen species (RONS) could disturb the cell membrane structure or trigger oxidative stress reactions while interacting with cells or bacteria, and these effects have been employed to treat some skin diseases or even tumors. [ 4–8 ]…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] For example, it has been proved that the reactive oxygen and nitrogen species (RONS) could disturb the cell membrane structure or trigger oxidative stress reactions while interacting with cells or bacteria, and these effects have been employed to treat some skin diseases or even tumors. [4][5][6][7][8] The development of plasma medicine relies on the progress of the plasma source. Atmospheric pressure plasma jet (APPJ) is the most commonly used reactor in plasma medicine.…”

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confidence: 99%

Self‐enhanced plasma brush for therapeutic use in dermatology and its safety assessment

Zhao

Yang

Liu

et al. 2022

Plasma Processes & Polymers

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In this study, a self-enhanced plasma brush based on a single dielectric barrier discharge was developed by optimizing the load position for treatment in dermatology. The electrical, optical, and temperature characteristics of the fabricated reactor were investigated. Results show that the length and the width of the plasma brush could reach 20 and 15 mm, respectively. The electric field and the resulting discharge

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Biological Effects of Cold Atmospheric Pressure Plasma on Skin Cancer

Cited by 10 publications

References 55 publications

Synergistic effect of cold atmospheric pressure plasma and free or liposomal doxorubicin on melanoma cells

Synergistic effect of cold atmospheric pressure plasma and free or liposomal doxorubicin on melanoma cells

Effect of direct plasma treatment and plasma‐treated liquid on cutaneous squamous cell carcinoma: A proof‐of‐concept study

Self‐enhanced plasma brush for therapeutic use in dermatology and its safety assessment

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