Biological Effects of a Chayotte Extract in Wistar Rats with Induced Diabetes: A Radiopharmaceutically Analysis

., G.F. Diré; ., J.S. Rodrigues; Oliveira, Jorge; Vasconcelos, Suzy Darlen Dutra de; ., P.R.A. Siqueira; Duarte, Rodrigo; ., M.C.L. Almeida; Fernandes, Maria da Luz; Bernardo-Filho, Mário

doi:10.3923/pjbs.2007.568.574

Cited by 5 publications

(3 citation statements)

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“…Especially important, given the high NCD (particularly diabetes) rates in the Pacific and northern Australia, are the anti-diabetes and anti-cardiovascular disease effects of most of the plants featured in the factsheets, demonstrated in scientific studies. Studies with evidence for this include the following: drumstick [ 36 , 37 , 38 , 50 , 60 ], amaranth [ 61 , 62 , 63 ], bele [ 64 , 65 , 66 ], chilli [ 67 , 68 , 69 ], purslane [ 70 , 71 , 72 ], kangkong [ 73 , 74 , 75 ], ofenga [ 76 , 77 , 78 ], hedge panax [ 79 , 80 ], chaya [ 39 , 40 ], pumpkin [ 81 , 82 ], and choko [ 83 , 84 ]. Their inclusion in the diet in sufficient quantity is likely to reduce the risk of diabetes and cardiovascular disease, not only by reducing glycemic load when they are included with high-carbohydrate meals, but also because of specific anti-diabetes effects.…”

Section: Resultsmentioning

confidence: 99%

Macro- and Micronutrients from Traditional Food Plants Could Improve Nutrition and Reduce Non-Communicable Diseases of Islanders on Atolls in the South Pacific

Lyons

Dean

Tongaiaba³

et al. 2020

Plants

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Pacific Islanders have paid dearly for abandoning traditional diets, with diabetes and other non-communicable diseases (NCD) widespread. Starchy root crops like sweet potato, taro, and cassava are difficult to grow on the potassium-deficient soils of atolls, and high energy, low nutrient imported foods and drinks are popular. Nutritious, leafy food plants adapted to alkaline, salty, coral soils could form part of a food system strategy to reduce NCD rates. This project targeted four atolls south of Tarawa, Kiribati, and was later extended to Tuvalu. Mineral levels in diverse, local leafy food plants were compared to reveal genotype–environment interactions. Food plants varied in ability to accumulate minerals in leaves and in tolerance of mineral-deficient soils. Awareness activities which included agriculture, health, and education officers targeted atoll communities. Agriculture staff grew planting material in nurseries and provided it to farmers. Rejuvenation of abandoned giant swamp taro pits to form diversified nutritious food gardens was encouraged. Factsheets promoted the most suitable species from 24 analyzed, with multiple samples of each. These included Cnidoscolus aconitifolius (chaya), Pseuderanthemum whartonianum (ofenga), Polyscias scutellaria (hedge panax), and Portulaca oleracea (purslane). The promoted plants have been shown in other studies to have anti-NCD effects. Inclusion of the findings in school curricula and practical application in the form of demonstration school food gardens, as well as increased uptake by farmers, are needed. Further research is needed on bioavailability of minerals in plants containing phytates and tannins.

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Section: Resultsmentioning

confidence: 99%

Macro- and Micronutrients from Traditional Food Plants Could Improve Nutrition and Reduce Non-Communicable Diseases of Islanders on Atolls in the South Pacific

Lyons

Dean

Tongaiaba³

et al. 2020

Plants

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“…Dire et al reported that the Sechium edule extract was able to modify the biodistribution of certain metabolites in the pancreas, such as AGE (Advanced Glycation End Products), which are characterized by inducing general inflammation in addition to other anomalies related to DM. Chayote modified and inactivated these molecules in an in vivo model with Windstar rats [ 135 ]. In another work, the relation between DM and other diseases and risk factors usually present, such as obesity, fatty liver, and hypertension, originated the search for natural alternatives that could reduce one or some of these risk factors.…”

Section: Selected Species Of the Cucurbitaceae Family Used In Mexico ...mentioning

confidence: 99%

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

et al. 2022

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In Mexico, Diabetes mellitus (DM) is a serious health problem, and although the current pharmacological treatments for DM such as insulin and oral hypoglycemics are available, the Mexican population continues to use medicinal plants in the treatment of DM. The antidiabetic properties of the plant species that belong to the Cucurbitaceae family has already been recognized worldwide. Since Mexico is one of the most important centers of diversity of Cucurbitaceae, the present work contributes to the review of the most used species of Cucurbitaceae in the treatment of DM in Mexico. The reviewed species (Cucurbita ficifolia, C. maxima, C. moschata, C. pepo, Ibervillea sonorae, Sechium edule, Citrullus lanatus, Cucumis melo, and C. sativus) revealed that the antidiabetic effects exerted are effective in a number of mechanisms involved in the complex pathogenesis of DM: hypoglycemic, antioxidant, anti-inflammatory, anti-obesity, protective effects on diverse organs and cells, as well as in the control of dyslipidemias; furthermore, the select species of the Cucurbitaceae family could also be essential components of diets for the control of DM in patients with the disease. Thus, the Cucurbitaceae species selected in the present work represent a source of antidiabetic agents that perhaps establish the bases for novel clinical treatments.

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“…45 In addition to having hypotensive and anti-inflammatory capacity 46 , it reduces the health risks associated with diabetes and obesity. 47,48 In a study conducted by Pérez-Ávila (2010) in which the hypoglycemic capacity of chayote juice was evaluated in Wistar rats with streptozotocin-induced diabetes, to which they were administered chayote juice diluted with drinking water in two presentations (filtered and unfiltered) finding that chayote juice diluted with unfiltered drinking water significantly decreased blood glucose concentration, in addition to presenting an increase in body weight of rats with diabetes, so the author suggests that such preparation may be a protective factor against diabetes. 49 Siahaan et al, (2017) carried out a study in which the effect of an ethanolic extract of chayote was analyzed in order to decrease the level of blood sugar, using an animal model (Mus musculus L), in which it was found that there was a significant difference with respect to the control group.…”

Section: In Vitromentioning

confidence: 99%

Evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus type 2

et al. 2020

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Diabetes mellitus is a disease that is characterized by the chronic presence of blood glucose levels caused by a defect in the secretion of insulin or in the action of this hormone in the body which must be treated integrally with a multidisciplinary approach. The natural treatment of this disease is a common practice around the world, especially in Latin America, there are several clinical studies, in vivo or in vitro assays that focus on assessing the hypoglycemic capacity of various natural products used empirically by the population for years for the phytotherapeutic treatment of the disease as well as the chemicals related to the mechanism of action that produces the hypoglycaemic effect. In the present article, a brief review of the evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus 2

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Biological Effects of a Chayotte Extract in Wistar Rats with Induced Diabetes: A Radiopharmaceutically Analysis

Cited by 5 publications

References 0 publications

Macro- and Micronutrients from Traditional Food Plants Could Improve Nutrition and Reduce Non-Communicable Diseases of Islanders on Atolls in the South Pacific

Macro- and Micronutrients from Traditional Food Plants Could Improve Nutrition and Reduce Non-Communicable Diseases of Islanders on Atolls in the South Pacific

Selected Species of the Cucurbitaceae Family Used in Mexico for the Treatment of Diabetes Mellitus

Evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus type 2

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