Biological Effectiveness of Methionine Hydroxy-analogue Calcium Salt in Relation to DL-Methionine in Broiler Chickens

Elwert, C.; Fernandes, Evandro de Abreu; Lemme, A.

doi:10.5713/ajas.2008.80201

Cited by 19 publications

(22 citation statements)

References 13 publications

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“…To the best of our knowledge, there are no previous published data on the RBV of MHA-Ca and DL-Met to support N retention and performance in pigs. It has been recently reported that, on a product-toproduct basis, the RBV of MHA-Ca relative to DL-Met was 63% in broiler chickens (Elwert et al, 2008) and 66% in chicks fed Met-deficient basal diet (Dilger and Baker, 2008). These RBV values are slightly lower than the RVB value of 71% on a product-to-product basis observed in the current study.…”

Section: Discussioncontrasting

confidence: 80%

“…In a recent study, Elwert et al (2008) reported that the mean RBV of MHA-Ca to DL-Met was 63% on a product-toproduct basis in broiler chickens. Likewise, Dilger and Baker (2008) reported that MHA-Ca was 65.6% as efficacious as DL-Met on a product-to-product basis in chicks.…”

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

“…Recently, the calcium salt of hydroxy analog of DL-methionine (MHA-Ca, 84%) was re-introduced to the market as an alternative Met source for poultry and swine in addition to DL-methionine 99%) and liquid MHA-free acid (MHA-FA, 88%) that have been utilized as Met sources during the past two decades (Elwert et al, 2008). Like MHA-FA, the re-introduction of MHA-Ca has generated questions about its relative bioavailability (RBV) compared with DL-Met as a Met source (Elwert et al, 2008). In animal nutrition, the term 'bioavailability' refers to the degree to which an ingested nutrient in a particular source is absorbed -E-mail: martin_nyachoti@umanitoba.ca in a form that is utilized for metabolic purposes by the animal (Littell et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Bioavailability of methionine hydroxy analog-calcium salt relative to dl-methionine to support nitrogen retention and growth in starter pigs

Opapeju

Htoo

Dapoza³

et al. 2012

Animal

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This study assessed the efficacy of a calcium salt of methionine hydroxy analog (MHA-Ca, 84%) relative to DL-methionine 99%) in starter pigs. In Experiment 1 (Exp. 1, N balance trial), 42 individually housed barrows (Genesus, average initial BW 19 kg) were used in two blocks of 21 pigs each with six replicates per treatment. Within each block, pigs were randomly allotted to seven diets: a methionine (Met)-deficient basal diet or the basal diet with three added levels of DL-Met (0.02%, 0.04% and 0.06%) or MHA-Ca (0.024%, 0.048% and 0.071%) on an equimolar basis. After a 7-day adaptation period, feces and urine were collected quantitatively for 5 days. Urinary and total N outputs decreased linearly (P , 0.05) with DL-Met or MHA-Ca supplementation. Nitrogen retention, expressed as g/day and as % of intake increased linearly (P , 0.01) with DL-Met and MHA-Ca supplementations. The relative efficacy of MHA-Ca to DL-Met was estimated to be 71.2% on a product-to-product basis for N retention expressed as % of intake. In Exp. 2 (performance trial), 280, 21-day-old crossbred (Pietrain 3 (Landrace 3 Large White)) pigs (eight pigs per pen, seven pens per treatment), were allocated to five diets in a completely randomized block design after a 10-day adaptation period. The Met-deficient basal diet contained 16.5% CP and 0.21% Met. Other diets were basal diet supplemented with two graded levels of DL-Met (0.04% and 0.08%) or MHA-Ca (0.062% and 0.12%) on a product basis at a DL-Met to MHA-Ca ratio of 65 : 100 at the expense of maize. BW and feed disappearance were monitored weekly for 3 weeks to determine performance. Final BW, average daily gain and average daily feed intake increased (P , 0.05) and feed to gain ratio decreased (P , 0.05) with the addition of Met to the basal diet irrespective of the source. Overall, the N retention results of Exp. 1 showed that the average relative bioavailability of MHA-Ca to DL-Met to support N retention (% of N intake) was 71% on a product-to-product basis (85% on an equimolar basis). In Exp. 2, pig performance was not different when Met was supplemented in the Met-deficient diet at a DL-Met to MHA-Ca ratio of 65 : 100 on a product basis.

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Section: Discussioncontrasting

confidence: 80%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioavailability of methionine hydroxy analog-calcium salt relative to dl-methionine to support nitrogen retention and growth in starter pigs

Opapeju

Htoo

Dapoza³

et al. 2012

Animal

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“…There have already been many discussions concerning the relative bioavailability of methionine from different sources, as well as a considerable number of experiments comparing various sources, mainly DL-HMBA and DLM, conducted in birds (Esteve-Garcia and Llaurado, 1997;Hoehler et al, 2005a;Elwert et al, 2008). Furthermore, the correct statistical design to evaluate the bioavailability of different sources of essential nutrients has been under debate (Littell et al, 1997;Kratzer and Littell, 2006;Piepho, 2006).…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of different methionine sources for broilers from 1 to 21 days old

et al. 2015

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. 2015. Bioavailability of different methionine sources for broilers from 1 to 21 days old. Cien. Inv. Agr. 42(1): 35-43. This trial aimed to evaluate the bioavailability of DL-2-hydroxy-4-(methyl) butanoic acid (DL-HMBA) and a poly-herbal ingredient (PHI) in relation to DL-methionine (DLM) on broilers. A sample of 1100 broiler chickens of the Cobb 500 strain, both male and female, were fed either a basal diet without industrial methionine supplementation or a basal diet that was supplemented with three DL-HMBA levels (0.170, 0.340, and 0.511%) or three DLM levels (0.111, 0.221, and 0.332%) in an amount equivalent to 65% of the respective DL-HMBA levels (on a product weight basis) and three levels of PHI (0.111, 0.221, and 0.332%) in amounts equivalent to the used DLM levels from 1 to 21 days of age. The simultaneous linear regression analysis (slope ratio) revealed a relative bioavailability of DL-HMBA of 39% compared to that of DLM for weight gain and 44% for feed conversion. However, the performance data from birds that were supplemented with PHI did not significantly adjust to simultaneous regression designs; therefore, it was not possible to determine the PHI bioavailability in relation to the DLM. Considering together all of the studied parameters, the relative bioavailability of DL-HMBA was 42% compared to the DLM on a product basis.

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Reply to: “Absorption of methionine sources in animals—is there more to know?” — Yes, there is more to know!

Lemme¹,

Dorigam²,

Mack³

2023

Animal Nutrition

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Biological Effectiveness of Methionine Hydroxy-analogue Calcium Salt in Relation to DL-Methionine in Broiler Chickens

Cited by 19 publications

References 13 publications

Bioavailability of methionine hydroxy analog-calcium salt relative to dl-methionine to support nitrogen retention and growth in starter pigs

Bioavailability of methionine hydroxy analog-calcium salt relative to dl-methionine to support nitrogen retention and growth in starter pigs

Bioavailability of different methionine sources for broilers from 1 to 21 days old

Reply to: “Absorption of methionine sources in animals—is there more to know?” — Yes, there is more to know!

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