Biological dynamics of hepatitis B virus load in dialysis population

Fabrizi, Fabrizio; Lunghi, G.; Alongi, G.; Bisegna, Sergio; Campolo, Gesualdo; Mangano, Stefano; Limido, Aurelio; Pagliari, B; Tettamanzi, Fabio; Ponticelli, Claudio

doi:10.1016/s0272-6386(03)00360-3

Cited by 23 publications

(35 citation statements)

References 25 publications

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“…[1][2][3][4] It is thought that liver injury associated with HBV infection is mediated by both viral factors and host immune response. [1,5] However, cellular immunity is often depressed in the uremic patients, [5][6][7][8] raising the question of why the clinical outcome of HBV infection in HD patients is different from that in the general population. On the other hand, is the viral factor of the uremic patients different from the general population?…”

Section: Discussionmentioning

confidence: 99%

“…One of the striking findings was that the HBV DNA levels (mean: 3.823, median: 3.384 Log 10 copies/mL) in these uremic patients were low, compatible with Fabrizi et al's report that the median HBV DNA level is 4.09 × 10 2 copies/mL in their uremic patients with HBV infection. [6] The REVEAL-HBV study has suggested that the HBV DNA level м4 Log 10 copies/mL is a critical predictor of HCC in the general population in Taiwan. [12,13] Divided by this cutoff value, 24 out of 30 (80%) of our uremic patients have HBV DNA level Ϲ4 Log 10 copies/mL, a higher percentage than the 55.7% subjects of the community-based HBV carriers in the REVEAL-HBV study.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8] A revised cutoff value of ALT (17 IU/L) for the uremic patients had been described previously.…”

Section: Definition Of High Alt Levelmentioning

confidence: 99%

“…[1][2][3][4] However, the natural course of hepatitis B virus (HBV) infection of the uremic patients remains unclear. [5][6][7][8][9][10][11] Recently, the REVEAL-HBV study from Taiwan demonstrate that an elevated viral load, serum HBV DNA level, is a strong risk factor predicting HCC and liver cirrhosis in HBV carrier. [12,13] As a few studies report, uremic patients with HBV infection usually have a low viral load.…”

Section: Introductionmentioning

confidence: 99%

“…[12,13] As a few studies report, uremic patients with HBV infection usually have a low viral load. [6] However, this phenomenon is due to the effect of hemodialysis (HD) or other factors in uremic patients combined with HBV infection. In this study, we are demonstrating for the first time that the HD procedure plays a crucial role in reducing the HBV DNA viral load in these uremic patients.…”

Section: Introductionmentioning

confidence: 99%

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Hemodialysis Reduces the Viral Load in Uremic Patients with Chronic Hepatitis B Infection

et al. 2008

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Background and aims. The effect of hemodialysis (HD) to change the viral load of hepatitis B virus (HBV) in uremic patients with chronic HBV infection has never been studied. In this study, we investigated the HBV viral loads and their changes between the HD procedure in the uremic patients. Patients and methods. A total of 38 chronic HBV-infected uremic patients were enrolled, but eight cases were excluded due to HCV co-infection and under anti-viral therapy. To evaluate the HBV DNA levels and their changes through the course of HD, we quantified serial serum samples from each patient immediately before HD, at the end of HD, and 48 hours later-immediately before the next HD. Results. Most of our HBV-infected uremic patients had a relatively lower HBV viral load; 80% cases with HBV DNA Ϲ4 Log 10 copies/mL, in comparison with the Taiwan epidemiologic study for community base HBV carriers. There was no significant difference of HBV DNA level between HBeAg-positive and -negative patients, but a significant higher DNA level in the high ALT group (p = 0.029) and liver cirrhosis patients (p = 0.002). The mean HBV DNA levels, before and after HD, respectively, in our 30 patients were 3.823 ± 1.130 Log 10 copies/mL and 3.686 ± 1.114 Log 10 copies/mL. It was a significant decrease on HBV DNA level in chronic HBV-infected patients through HD procedure (p = 0.004). The mean HBV DNA level of two days after HD was 3.702 ± 1.094 Log 10 copies/ mL, which was not significantly different from the HBV DNA level before (p = 0.076) or after (p = 0.267) HD; however, the mean reduction of HBV DNA by a single HD was 0.11 ± 0.38 Log 10 copies/mL. Patients with low viral load also had a signifi-

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8] A revised cutoff value of ALT (17 IU/L) for the uremic patients had been described previously.…”

Section: Definition Of High Alt Levelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hemodialysis Reduces the Viral Load in Uremic Patients with Chronic Hepatitis B Infection

et al. 2008

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Low HBV‐DNA levels in end‐stage renal disease patients with HBeAg‐negative chronic hepatitis B

Moutinho

Perez

Medina-Pestana

et al. 2006

Journal of Medical Virology

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In end-stage renal disease patients treated by hemodialysis with HBeAg-negative chronic hepatitis B virus (HBV) infection, the evaluation of the presence of viral replication is essential in the assessment for renal transplantation. Data on HBV viral load, prevalence of precore mutations, as well as the influence of HCV coinfection on HBV-DNA levels in this group of patients is scarce. The aim of this study was to determine the HBV viral load in HBsAg-positive/HBeAg-negative hemodialysis patients; to compare HBV-DNA levels between isolated HBV infection carriers and HBV-HCV coinfected patients, and to evaluate the prevalence of precore mutations in these patients. Fifty hemodialysis patients with chronic HBeAg-negative HBV infection were studied. Viral load was determined by PCR (Amplicor HBV Monitor-Roche). The detection of precore mutations was made by sequencing. Of a total of 50 patients, 76% were male, with a mean age of 44 +/- 11 years. Anti-HCV was positive in 56% of patients. HBV-DNA was undetectable in 58% of patients; 24% had HBV-DNA <10,000 copies/ml, 12% between 10,000-100,000 copies/ml, and only 6% had HBV-DNA >100,000 copies/ml. There was no difference in the viral load of patients infected only by HBV and HBV-HCV co-infected patients (P = 0.96). Precore mutations were detected in only 8% of cases. In conclusion, hemodialysis patients with HBeAg-negative HBV infection had a low viral load. Precore mutations were infrequent and the presence of anti-HCV has not influenced the levels of HBV-DNA.

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Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil

Villar

Fraga²,

Mendonça³

et al. 2022

The Brazilian Journal of Infectious Diseases

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Biological dynamics of hepatitis B virus load in dialysis population

Cited by 23 publications

References 25 publications

Hemodialysis Reduces the Viral Load in Uremic Patients with Chronic Hepatitis B Infection

Hemodialysis Reduces the Viral Load in Uremic Patients with Chronic Hepatitis B Infection

Low HBV‐DNA levels in end‐stage renal disease patients with HBeAg‐negative chronic hepatitis B

Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil

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