2009
DOI: 10.1371/journal.pone.0004544
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Biological Convergence of Cancer Signatures

Abstract: Gene expression profiling has identified cancer prognostic and predictive signatures with superior performance to conventional histopathological or clinical parameters. Consequently, signatures are being incorporated into clinical practice and will soon influence everyday decisions in oncology. However, the slight overlap in the gene identity between signatures for the same cancer type or condition raises questions about their biological and clinical implications. To clarify these issues, better understanding … Show more

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Cited by 22 publications
(18 citation statements)
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“…ADCY3 expression may be affected by promoter CpG methylation, a well-known epigenetic mechanism for cancer-specific changes in gene expression. According to the encyclopedia of DNA elements (ENCODE) annotation [36], the region of the ADCY3 promoter analyzed in our study harbors binding sites for critical transcription factors, including early growth response protein 1 (Egr-1), E2F, and activating protein 2 (AP-2), which are known to promote the development of an environment conducive for tumor formation [37,38]. It is possible that environmental factors alter the methylation status of the ADCY3 promoter region, upregulating the expression of ADCY3 in gastric tissue.…”
Section: Discussionmentioning
confidence: 99%
“…ADCY3 expression may be affected by promoter CpG methylation, a well-known epigenetic mechanism for cancer-specific changes in gene expression. According to the encyclopedia of DNA elements (ENCODE) annotation [36], the region of the ADCY3 promoter analyzed in our study harbors binding sites for critical transcription factors, including early growth response protein 1 (Egr-1), E2F, and activating protein 2 (AP-2), which are known to promote the development of an environment conducive for tumor formation [37,38]. It is possible that environmental factors alter the methylation status of the ADCY3 promoter region, upregulating the expression of ADCY3 in gastric tissue.…”
Section: Discussionmentioning
confidence: 99%
“…28 Our analyses led to the identification of a large panel of genes differentially expressed between "γδ-susceptible" and "γδ-resistant" tumors. Importantly, we verified that there was no correlation between intrinsic anti-apoptotic properties and resistance to γδ-PBL cytotoxicity, both in terms of gene expression and response to a death stimulus.…”
Section: Discussionmentioning
confidence: 99%
“…These studies have been performed in breast, colorectal, pancreatic, and lung cancers and glioblastoma and, overall, have identified almost 400 candidate cancer genes (CANgenes) (48,83,134,199). Interestingly, systems-level analyses show that, despite the low degree of overlap in terms of gene identity, cancer signatures converge on specific biological processes, as defined by significant molecular and functional associations between genes and/or proteins (68, 163,170).…”
Section: Multiple "Undefined" Antigensmentioning
confidence: 99%