Biological control in a plutonium production facility. Mackenzie Davidson Memorial Lecture, Thursday, May 17, 1979

Gb, Schofield

doi:10.1259/0007-1285-53-629-398

Cited by 11 publications

(1 citation statement)

References 7 publications

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“…That the analysis for radionuclides in tissues removed from nuclear workers at autopsy had been undertaken was already known when the Redfern Inquiry was established-a number of papers published in the open scientific literature had referred to this work, for example, Schofield (1980) and Lawson et al (1989) refer to results for Sellafield workers, while Donoghue et al (1972) and Roberts et al (1977) refer to findings for Springfields workers. One reason for the unexpected length of the Inquiry is that although attention was initially concentrated on BNFL workers, and especially Sellafield, it quickly became apparent to the Inquiry that scientific research involving the radionuclide content of tissues removed at autopsy had been carried out elsewhere, notably projects involving members of the public conducted by the Medical Research Council (MRC) and the National Radiological Protection Board (NRPB, now the Radiation Protection Division of the Health Protection Agency).…”

Section: Reflections On the Redfern Inquirymentioning

confidence: 99%

Reflections on The Redfern Inquiry

Wakeford¹

2010

J. Radiol. Prot.

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Section: Reflections On the Redfern Inquirymentioning

confidence: 99%

Reflections on The Redfern Inquiry

Wakeford¹

2010

J. Radiol. Prot.

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mFISH analysis of chromosome aberrations in workers occupationally exposed to mixed radiation

Sotnik

Osovets

Scherthan

et al. 2014

Radiat Environ Biophys

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We performed a study on the presence of chromosome aberrations in a cohort of plutonium workers of the Mayak production association (PA) with a mean age of 73.3 ± 7.2 years to see whether by multi-color fluorescence in situ hybridization (mFISH) translocation analysis can discriminate individuals who underwent occupational exposure with internal and/or external exposure to ionizing radiation 40 years ago. All Mayak PA workers were occupationally exposed to chronic internal alpha-radiation due to incorporated plutonium-239 and/or to external gamma-rays. First, we obtained the translocation yield in control individuals by mFISH to chromosome spreads of age-matched individuals and obtained background values that are similar to previously published values of an international study (Sigurdson et al. in Mutat Res 652:112-121, 2008). Workers who had absorbed a total dose of >0.5 Gy external gamma-rays to the red bone marrow (RBM) displayed a significantly higher frequency of stable chromosome aberrations relative to a group of workers exposed to <0.5 Gy gamma-rays total absorbed RBM dose. Thus, the translocation frequency may be considered to be a biological marker of external radiation exposure even years after the exposure. In a group of workers who were internally exposed and had incorporated plutonium-239 at a body burden >1.48 kBq, mFISH revealed a considerable number of cells with complex chromosomal rearrangements. Linear associations were observed for translocation yield with the absorbed RBM dose from external gamma-rays as well as for complex chromosomal rearrangements with the plutonium-239 body burden.

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Science and trans-science in radiation risk assessment: Child cancer around the nuclear fuel reprocessing plant at Sellafield, U.K.

Crouch

1986

Science of The Total Environment

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Biological control in a plutonium production facility. Mackenzie Davidson Memorial Lecture, Thursday, May 17, 1979

Cited by 11 publications

References 7 publications

Reflections on The Redfern Inquiry

Reflections on The Redfern Inquiry

mFISH analysis of chromosome aberrations in workers occupationally exposed to mixed radiation

Science and trans-science in radiation risk assessment: Child cancer around the nuclear fuel reprocessing plant at Sellafield, U.K.

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