Biological consequences of human immunodeficiency virus type 1 envelope polymorphism: does variation matter?: 1995 Fleming Lecture Delivered at the 134th Meeting of the Society for General Microbiology, 26 March 1996

McKeating, Jane A.

doi:10.1099/0022-1317-77-12-2905

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Rbac 2016;48(4):301-61

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Cited by 9 publications

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“…(28) O HIV infecta células que tenham o marcador CD4 (CD4 + ), principalmente linfócitos T auxiliares, (29) mas também macrófagos teciduais e células da micróglia do sistema nervoso central, o que resulta em uma doença crônica e progressiva, ocasionando uma depressão imunológica. (30) O ciclo replicativo do HIV-1 pode ser dividido em duas fases, a fase precoce e a fase tardia. A fase precoce começa com o reconhecimento da célula alvo pelo vírus maduro e envolve todos os processos que conduzem à integração do cDNA genômico no cromossoma da célula hospedeira.…”

Section: Rbac 2016;48(4):301-6unclassified

Pathogenesis of Hiv - Classification, Characteristics of the Virus and Mother to Child Transmission

Rosa¹,

Silva²,

Hora³

2016

Revista Brasileira De Análises Clínicas

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Section: Rbac 2016;48(4):301-6unclassified

Pathogenesis of Hiv - Classification, Characteristics of the Virus and Mother to Child Transmission

Rosa¹,

Silva²,

Hora³

2016

Revista Brasileira De Análises Clínicas

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The role of the hepatitis C virus glycoproteins in infection

Flint

McKeating

2000

Rev. Med. Virol.

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Effect of Changes in the Glycosylation of the Human Immunodeficiency Virus Type 1 Envelope on the Immunoreactivity and Sensitivity to Thrombin of Its Third Variable Domain

Papandréou

Fenouillet

1998

Virology

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The influence of HIV Env glycosylation on the conformation of the third variable domain (V3) of Env was studied by both deglycosylation of mature Env and the use of Env produced by recombinant systems in which alpha-glucosidase activity was inhibited by either deoxynojirimycin (DNM) or mutation. Selective deglycosylation affected anti-V3 antibody binding. The immunoreactivity and sensitivity to thrombin cleavage of V3 presented on Env produced in baby hamster kidney cells were changed by DNM treatment. In contrast, Env expressed in alpha-glucosidase I-deficient Chinese hamster ovary cells or in their parental cells treated by DNM fully retained these V3 properties. These results are discussed in relation to the inconsistent data obtained on V3 property changes resulting from Env glycosylation changes.

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Biological consequences of human immunodeficiency virus type 1 envelope polymorphism: does variation matter?: 1995 Fleming Lecture Delivered at the 134th Meeting of the Society for General Microbiology, 26 March 1996

Cited by 9 publications

References 123 publications

Pathogenesis of Hiv - Classification, Characteristics of the Virus and Mother to Child Transmission

Pathogenesis of Hiv - Classification, Characteristics of the Virus and Mother to Child Transmission

The role of the hepatitis C virus glycoproteins in infection

Effect of Changes in the Glycosylation of the Human Immunodeficiency Virus Type 1 Envelope on the Immunoreactivity and Sensitivity to Thrombin of Its Third Variable Domain

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