Nature strategies have a constructive effect on the sustainable solution, but due to the complexities of nature's strategies and its interdisciplinary character, we need to know the process of architectural creation with framing inspired by nature. We need to change behavior and develop sustainable thinking as an intellectual system, which is possible by taking advantage of the rich source of nature knowledge. Considering the scale of biological information, the lack of ease of recognizing and applying nature's strategies, it requires the conceptual model. The main question is to establish a clear connection between the mentioned concepts, discover the effective components in the design process, which creates new paths to reach innovative designs inspired by nature. The research shows that: the biological framing of the architectural creation process begins based on the design problem solving approach. Biological knowledge and information, in addition to affecting the quality and capability of the product, also causes changes in the architectural creation process. The most important effect of it is to change the type of attitude in design in order to achieve harmony and create a balance between the human made environment and nature, increasing productivity and achieving stability, not reducing the amount of instability.