Biological chemotaxis-guided self-thermophoretic nanoplatform augments colorectal cancer therapy through autonomous mucus penetration

Abstract

Oral drug delivery systems have great potential to treat colorectal cancer (CRC). However, the drug delivery efficiency is restricted by limited CRC-related intestine positioning and dense mucus barrier. Here, we present a biological chemotaxis-guided self-thermophoretic nanoplatform that facilitates precise intestinal positioning and autonomous mucus penetration. The nanoplatform introduces asymmetric platinum-sprayed mesoporous silica to achieve autonomous movement in intestinal mucus. Furthermore, inspired by the intense interaction between pathogenic microbes and CRC, the nanoplatform is camouflaged by Staphylococcus aureus membrane to precisely anchor in CRC-related intestine. Owing to 4.3-fold higher biological chemotactic anchoring of CRC-related intestine and 14.6-fold higher autonomous mucus penetration performance, the nanoplatform vastly improves the oral bioavailability of cisplatin, leading to a tumor inhibition rate of 99.1% on orthotopic CRC–bearing mice. Together, the exquisitely designed nanoplatform to overcome multiple physiological barriers provides a new horizon for the development of oral drug delivery systems.

Self‐Propelled Proteomotors with Active Cell‐Free mtDNA Clearance for Enhanced Therapy of Sepsis‐Associated Acute Lung Injury

“…This may be attributed to the self-propulsion of DNase-I/HSA NMs which contributed to prolong lung retention and increase catalytic efficiency, as mentioned above. [38,68,69] Taken together, the DNase-I/HSA NMs exhibited more effective to alleviate lung inflammation and protect mice from sepsisassociated ALI, compare with free DNase-I.…”

In vivoapplications of micro/nanorobots

“…Reproduced with permission. 85 Copyright 2022, American Association for the Advancement of Science. (d) Protective capsules loaded with algae-based microrobots as self-motile drug delivery platforms.…”

“…Another type of application was treating colorectal cancer via NIR light-driven nanorobots. 85 The nanorobots consisted of Pt-coated mesoporous silica having a specific camouflage ( S. aureus membrane) and a chemotherapeutic drug (cisplatin). While NIR light provided the stimulus for the motion, the biomimetic camouflage guided the nanorobots toward the intestinal site of colorectal cancer, as demonstrated in Fig.…”

“…(c) NIR light-driven nanorobots with mucus penetration ability to deliver a chemotherapeutic drug for the treatment of colorectal cancer. Reproduced with permission 85. Copyright 2022, American Association for the Advancement of Science.…”

Self‐Propelled Enzymatic Nanomotors from Prodrug‐Skeletal Zeolitic Imidazolate Frameworks for Boosting Multimodel Cancer Therapy Efficiency

“…[3,4] Especially for cancer therapy, recent advances in micro/nanomotor research have made great progress in minimally invasive surgery, active drug delivery, and others due to their autonomous motion behavior and tunable functionality. [5] As an upgrade version of drug delivery platform, a variety of micro/nanomotors, driven by light, [6] heat, [7] magnetic fields, [8] ultrasounds, [9] chemical reactions, [10,11] or by living organisms, [12,13] have been well developed for their self-propulsion and delivering drug on-command, and have demonstrated great superiority for cancer therapy. Among them, chemical motors that converting localized chemical energy into mechanical energy using self-destructive reactions or catalyzed reactions is the most developed item for cancer therapy due to their microenvironmental response.…”