Biological, Chemical, and Omics Research of <i>Taxus</i> Medicinal Resources

Hao, Da‐Cheng; Xiao, Pei‐Gen; Ge, Guangbo; Liu, Ming

doi:10.1002/ddr.21040

Cited by 20 publications

(12 citation statements)

References 84 publications

(120 reference statements)

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“…Besides paclitaxel (PACL), 10-deacetylbaccatin III (10-DAB), the precursor of PACL, is also of high importance [6,7]. It has also been used extensively for the semi-synthesis of Taxotere, which shows a more efficient anti-tumor activity than taxol, as well as the analogue of PACL, cephalomannine Data 2020, 5, 22 2 of 6 (CEPH) [6,8]. Other taxanes that are collected from the Taxus species are baccatin III (BAC), brevifoliol and 9-dihydro-13-acetylbaccatin III (9-DAB III) [9].…”

Section: Discussionmentioning

confidence: 99%

Dataset of Targeted Metabolite Analysis for Five Taxanes of Hellenic Taxus baccata L. Populations

Dalmaris¹,

Avramidou²,

Xanthopoulou³

et al. 2020

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Novel primary sources of one of the world’s leading anticancer agent, paclitaxel, as well as of other antineoplastic taxanes such as 10-deacetylbaccatin-III, are needed to meet an increasing demand. Among the Taxus species the promise of Taxus baccata L. (European or English yew) has been documented. In this study, the metabolite analysis of two marginal T. baccata populations in Greece (Mt. Cholomon and Mt. Olympus), located at the southeastern edge of the species natural distribution, are being explored. A targeted liquid chromatography – mass spectrometry (LC-MS/MS) analysis was used to determine the content of 10-deacetylbaccatin III, baccatin III, 10-deacetyltaxol, paclitaxel and cephalomannine in the needles of each of the populations from three sampling periods (spring, summer and winter). This is the first survey to generate a taxane targeted metabolite data set, since it derives from Hellenic natural populations that have not been explored before. Furthermore, it has used an extensive sample design in order to evaluate chemodiversity at the population level. The analysis revealed significant levels of chemodiversity within and among the investigated populations and significant seasonal variation that could be exploited for the selection of superior germplasm native to Greece, for yew plantations and further exploitation which is necessary for the production of important taxanes.

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Section: Discussionmentioning

confidence: 99%

Dataset of Targeted Metabolite Analysis for Five Taxanes of Hellenic Taxus baccata L. Populations

Dalmaris¹,

Avramidou²,

Xanthopoulou³

et al. 2020

Data

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“…Taxus species are well known for their taxane secondary metabolites , which have various pharmacological activities, for example, anticancer activity. Taxus rhizosphere harbors diverse microbes and has great functional potential.…”

Section: Discussionmentioning

confidence: 99%

“…Taxus is the source plant of anti‐cancer drug paclitaxel and its biosynthetic precursor, analogs and derivatives, which has been studied for decades . There are many endemic Taxus species in China, which have been studied in the field of multiple disciplines.…”

Section: Introductionmentioning

confidence: 99%

“…There are many endemic Taxus species in China, which have been studied in the field of multiple disciplines. The importance of Taxus , as the potential model gymnosperm plant, has been highlighted by the numerous studies of Taxus biology and chemistry . However, gaps are present in knowledge about the genomics, epigenomics, transcriptomics, proteomics, metabolomics, and bioinformatics of Taxus and the associated microbes.…”

Section: Introductionmentioning

confidence: 99%

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The first Taxus rhizosphere microbiome revealed by shotgun metagenomic sequencing

2018

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In the present study, the shotgun high throughput metagenomic sequencing was implemented to globally capture the features of Taxus rhizosphere microbiome. Total reads could be assigned to 6925 species belonging to 113 bacteria phyla and 301 species of nine fungi phyla. For archaea and virus, 263 and 134 species were for the first time identified, respectively. More than 720,000 Unigenes were identified by clean reads assembly. The top five assigned phyla were Actinobacteria (363,941 Unigenes), Proteobacteria (182,053), Acidobacteria (44,527), Ascomycota (fungi; 18,267), and Chloroflexi (15,539). KEGG analysis predicted numerous functional genes; 7101 Unigenes belong to "Xenobiotics biodegradation and metabolism." A total of 12,040 Unigenes involved in defense mechanisms (e.g., xenobiotic metabolism) were annotated by eggNOG. Talaromyces addition could influence not only the diversity and structure of microbial communities of Taxus rhizosphere, but also the relative abundance of functional genes, including metabolic genes, antibiotic resistant genes, and genes involved in pathogen-host interaction, bacterial virulence, and bacterial secretion system. The structure and function of rhizosphere microbiome could be sensitive to non-native microbe addition, which could impact on the pollutant degradation. This study, complementary to the amplicon sequencing, more objectively reflects the native microbiome of Taxus rhizosphere and its response to environmental pressure, and lays a foundation for potential combination of phytoremediation and bioaugmentation.

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“…The biological and chemical studies of Papaver (Desgagné-Penix et al, 2010), Taxus (Hao et al, 2011) and Polygonum (Hao et al, 2012a) with the use of omics technologies provide a paradigm of the active integration of various state-ofthe-art methodologies into the early stage of drug research and development. Increasing interest in Chelidonieae pharmaceutical resources has led to additional discoveries of alkaloids, terpenoids, flavonoids, and many other compounds in various Chelidonieae species and to studies on their chemotaxonomy, molecular phylogeny, and pharmacology.…”

Section: Discussionmentioning

confidence: 99%