Biological characterization of sulfoxaflor, a novel insecticide

Abstract

The novel chemistry of sulfoxaflor, its unique biological spectrum of activity and its lack of cross-resistance highlight the potential of sulfoxaflor as an important new tool for the control of sap-feeding insect pests.

Overall status of neonicotinoid insecticides in China: Production, application and innovation

“…13,14) It exhibits high potency and lacks insecticidal cross-resistance; thus it could be used as an alternative to control sap-feeding insect pests. 15) It is expected to be introduced in 2013 in China as long as the registrations are granted. Starting from the core structure of Sulfoxaflor, Professor Jianxin Fang from Nankai University synthesized some thiazolyl analogues by replacing pyridyl in Sulfoxaflor with a thiazolyl moiety.…”

Novel nicotinic action of the sulfoximine insecticide sulfoxaflor

“…Structure optimization led to the discovery of the insecticide sulfoxaflor ( Fig. 2) with potent, broad spectrum activity for sap-feeding pests (Babcock et al, 2011;Zhu et al, in press). Sulfoxaflor has thus far proven to lack cross-resistance in strains of whiteflies and brown planthopper that are likely resistant to the commercial neonicotinoid insecticides due to metabolic detoxification mechanisms (Babcock et al, 2011;Zhu et al, in press).…”

“…Insecticides acting at insect nicotinic acetylcholine (ACh) receptors (nAChRs) have proven particularly useful for the control of aphids and whiteflies, especially the neonicotinoid class ( Fig. 1), which represented nearly one-fourth of all insecticide sales globally in 2007 (Jeschke and Nauen, 2008;Babcock et al, 2011). Imidacloprid (IMI, Fig.…”

Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety

“…9 In recent years, studies for development of novel potential insecticidal molecules with the triuoromethyl pyridine are very popular, and large number of potential compounds with this substructure were reported. [10][11][12][13][14][15][16] Such as sulfoxaor, a representative commercial insecticide, and was industrialized by Dow Agroscience. 16 1,3,4-Oxadiazole derivative is a highly active pharmacophore and widely was used in pesticide molecules, 17 many active substance containing such a scaffold have been reported as insecticides, [18][19][20][21][22][23][24] fungicides, [25][26][27][28][29][30][31] and herbicides, 32-34 some of them were treated as a pesticide candidate for further industrialization.…”

“…[10][11][12][13][14][15][16] Such as sulfoxaor, a representative commercial insecticide, and was industrialized by Dow Agroscience. 16 1,3,4-Oxadiazole derivative is a highly active pharmacophore and widely was used in pesticide molecules, 17 many active substance containing such a scaffold have been reported as insecticides, [18][19][20][21][22][23][24] fungicides, [25][26][27][28][29][30][31] and herbicides, 32-34 some of them were treated as a pesticide candidate for further industrialization. 25 Recently, Liu and co-workers reported the 1,3,4-oxadiazole derivative with an anthranilic diamide moiety possessed excellent insecticidal activity against P. xylostella, 20 as well as some insecticidal sarisan analogues with an 1,3,4-oxadiazole scaffold were developed by Guo et al 23,35 And in our recent work, a series of insecticidal 1,3,4-oxadiazole molecules bearing a 3-chloropyridin-2-yl-1H-pyrazole was proposed.…”