Biological cell positioning and spatially selective destruction via magnetic nanoparticles

Gertz, Frederick; Azimov, Rustam; Khitun, Alexander

doi:10.1063/1.4730945

Cited by 18 publications

(8 citation statements)

References 20 publications

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“…Cell velocities were then be determined by the trajectories of cells that were attracted by the DWs and the trapping force would be estimated to be about 2.8 to 7.9 pN for square elements and 1.1 to 3.5 pN for ring elements. The order of piconewton that microbeads and cells experienced was similar to that of previous literature, [ 23 , 24 ] and this show the possibility of utilizing geometrically constrained DWs as an alternative approach to separate, capture.…”

Section: Resultssupporting

confidence: 84%

Concentric Magnetic Structures for Magnetophoretic Bead Collection, Cell Trapping and Analysis of Cell Morphological Changes Caused by Local Magnetic Forces

Huang

Wei

2015

PLoS ONE

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Concentric magnetic structures (ring and square) with domain wall (DW) pinning geometry are designed for biological manipulation. Magnetic beads collection was firstly demonstrated to analyse the local magnetic field generated by DWs and the effective regions to capture magnetic targets of size 1 μm. Primary mouse embryonic fibroblasts (MEFs) are magnetically labeled by internalizing poly (styrene sulfonic acid) stabilized magnetic nanoparticles (PSS-MNPs) and then are selectively trapped by head-to-tail DWs (HH DWs) or tail-to-tail DWs (TT DWs) to be arranged into linear shape or cross shape. The morphologies and the nuclear geometry of the cells growing on two kinds of concentric magnetic structures are shown to be distinctive. The intracellular magnetic forces generated by the local magnetic field of DWs are found to influence the behaviour of cells.

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Section: Resultssupporting

confidence: 84%

Concentric Magnetic Structures for Magnetophoretic Bead Collection, Cell Trapping and Analysis of Cell Morphological Changes Caused by Local Magnetic Forces

Huang

Wei

2015

PLoS ONE

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“…The gradient of this non-uniform magnetic field causes the magnetic NPs to be attracted towards the wires. Therefore, the movement of magnetic NPs pulls biological cells in the same direction [32]. Figure 4(B) shows the numerical results of the magnetic energy above the two straight wires.…”

Section: Nanoparticle Manipulations For Biomedical Applicationsmentioning

confidence: 98%

“…As an example, this method [32] is used for focusing and selective destruction of red blood cells (RBCs) via magnetic NPs. The experiment was accomplished above the micro-electromagnet serving concurrently as a source of the magnetic field and as a local heater.…”

Section: Nanoparticle Manipulations For Biomedical Applicationsmentioning

confidence: 99%

Magnetohydrodynamics in Biomedical Applications

Farrokhi¹,

Otuya²,

Khimchenko³

et al. 2020

Nanofluid Flow in Porous Media

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This chapter discusses recent advances in biomedical applications of magnetohydrodynamics (MHD). The magnetohydrodynamic (MDH) effect is a physical phenomenon describing the motion of a conducting fluid flowing under influencing of an external magnetic field. The chapter covers four primary areas of research: (1) laser beam scanning, (2) nano-particle manipulation, (3) imaging contrast enhancement, and (4) targeted drug delivery. The state-of-the-art devices based on magnetohydrodynamic principles are also presented, providing a broad view of biomedical MHDs. As the field of biomedical MHDs continues to grow, advances towards micro-scale transitions will continue to be made, maintaining its clinically driven nature and motion towards real-world applications.

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“…There are some special kind of nanostructured materials like bio-magnetic nanoparticles which is important to consider the physico-chemical and electro-magnetic properties of nanostructured materials specially MNPs which will be composed at least magnetic element. So, these materials has attracted much interest which has been caused to extend wide range of applications like ferro fluid solutions, magnetic storage devices, bio-sensing application, magnetic power generations and conversion, magnetic controlled drug delivery, magnetic resonance imagining as a contrast agents [61][62][63][64][65][66][67][68][69][70][71][72][73][74]. For biomedical applications, magnetic nanoparticles must (1) have a good thermal stability; (2) larger magnetic moment; (3) be biocompatible; (4) be able to form stable dispersion so the particles could be transported in living system; and (5) well response to AC magnetic fields.…”

Section: Biomedical Applications Of Fe 3 O 4 Magnetic Nanoparticlesmentioning

confidence: 99%

Iron Oxide Biomagnetic Nanoparticles (IO-BMNPs); Synthesis, Characterization and Biomedical Application–A Review

Nochehdehi¹,

Thomas²,

Sadri³

et al. 2017

J Nanomed Nanotechnol

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Nanotechnology is a multidisciplinary branch of science which encompasses numerous diverse fields of science and technology, ranging from biomedical, pharmaceutical, agricultural, environmental, advanced materials, chemical science, physics, electronics, information technology, and so on. Physical and Chemical properties as a major advantages of Nanoparticles can be used in various applications from Industries to medicine. Besides, Magnetic nanoparticles for medical applications have been developed by many researchers. In recent decades, it has received attention by virtue of their potential for applications in different fields. Due to several advantages and widespread applications of magnetic Nanoparticles in biotechnology, medical, material science, engineering, and environmental areas, much attention has been paid to the synthesis of different kinds of Biomagnetic nanoparticles (BMNPs). Core-shell nanoparticles include of coated various materials like: biopolymers (Chitosan, PAA) and bioceramics (Hydroxyapatite) as a shell on top of them and different hard and soft materials like metal oxide (Iron oxide and Cob alt composite) as a core. Improved properties of core-shell nanoparticles like less cytotoxicity, increase biocompatibility, decrease in an interactions with biomolecules, increase physicochemical stability and sort of that, can be due to their use in biological applications. After reviewing several research and review articles and synthesis procedure of Iron based Bio-magnetic Nanoparticles (BMNPs), we should emphasize that, It can be used in different applications like magnetic resonance imaging (MRI), drug delivery systems (DDS), immunoassay, also specially in diagnosis and treatment of cancer via hyperthermia (heat therapy) method.

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Biological cell positioning and spatially selective destruction via magnetic nanoparticles

Cited by 18 publications

References 20 publications

Concentric Magnetic Structures for Magnetophoretic Bead Collection, Cell Trapping and Analysis of Cell Morphological Changes Caused by Local Magnetic Forces

Concentric Magnetic Structures for Magnetophoretic Bead Collection, Cell Trapping and Analysis of Cell Morphological Changes Caused by Local Magnetic Forces

Magnetohydrodynamics in Biomedical Applications

Iron Oxide Biomagnetic Nanoparticles (IO-BMNPs); Synthesis, Characterization and Biomedical Application–A Review

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