Biological behavior of 67Ga-citrate in New Zealand White rabbits

Abstract

The pharmacokinetics, protein binding, excretion and tissue distribution of 67Ga after the administration of 67Ga-citrate to New Zealand White rabbits is described. Data for 67Ga blood levels were best described by an equation with three exponential components exhibiting half lives of 0.25 h, 7.4 h and 19.5 h, with almost all of the activity in a protein bound form. Weekly urinary excretion (approximately 27%), possibly in a metabolized form, and fecal elimination (approximately 20%) were greater than the reported values in man, but there was a similar organ distribution pattern in these animals as in man. The overall biological handling was judged to be similar in both species making the rabbit a suitable model for further 67Ga-citrate studies in vivo.

A simple and rapid automated radiosynthesis of [18F]fluoroacetate

“…[3][4][5][6][7] However, most of these syntheses needed a long synthesis time (460 min) and provided a low radiochemical yield (o34%). [3][4][5][6] Padgett et al 7 reported a chemistry process control unit for the automated production of [ 18 F]FAC using commercial benzyl bromoacetate as a precursor with a high corrected radiochemical yield (460%). However, this twostep two-pot procedure still needed a long synthesis time (440 min).…”