Biological augmentation to promote meniscus repair: from basic science to clinic application—state of the art

Parameniscal cysts are defined as an internal disorder of the knee joint. It is known that parameniscal cysts are associated with horizontal meniscal tears that could lead to the collection of synovial fluid within the cyst. Despite the treatment of meniscal tears, cyst recurrence is still an issue that needs to be addressed. In this regard, there has been an increasing interest in the use of biologic agents to enhance the vascularity and healing of the meniscus. Preliminary results for biologic therapeutic agents, such as growth factors, bone marrow, and aspirate concentrate, have been encouraging. However, these options are more demanding in regards to time, financial burden, resources, and so on. Autologous platelet-rich plasma is readily available, easy to use, affordable, and minimally invasive. This Technical Note will describe a step-by-step and reproducible technique for the harvesting, preparation, and use of an autologous platelet-rich fibrin matrix used to augment the healing of meniscal repairs.

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“…However, most of them are too expensive, with scant clinical data that can be used in clinical practice. 10 …”

Section: Discussionmentioning

confidence: 99%

Autologous Platelet-Rich Fibrin Matrix–Augmented Repair for Parameniscal Cysts: Surgical Technique

Screpis

Natali

Piovan

et al. 2021

Arthroscopy Techniques

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“…Alginate is a natural macromolecular compound extracted from seaweed, which has very good bio adhesion, biocompatibility and biodegradability, so alginate has great advantages as a material for manufacturing bones [6]. Through the injection experiment of sodium alginate gel in goat knee, Reference [15] concluded that in meniscus, bone marrow mesenchymal thousand cells containing hIGF-1 gene and sodium alginate gel can be mixed injected to smelt furuncle to realize tissue reconstruction [16]. He also found biomedical grade, low viscosity and high mannose acid alginate cultured cells in vitro through in vitro culture experiments, and the survival rate of cells was the highest; The cells cultured with biomedical grade, low viscosity and high glycogen acid have the best survival state; The yield of proteoglycan was the highest in biomedical grade, medium viscosity and high mannose culture.…”

Section: Natural Polymer Materialsmentioning

confidence: 99%

Research and analysis on key issues of 3D printing human bones

Zhang

2023

ACE

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Bone repair surgery is a highly challenging surgical procedure, requiring not only the technical skills of experienced surgeons, but also the suitability of bone materials for individual patients. Additionally, the patient's recovery process plays an important role in the success of the surgery. To address these challenges, various types of 3D printing technologies have been developed, with a focus on material selection and structural analysis. In this study, the authors analyse and summarize different materials and printing structures used in 3D printed bones, as well as the application of this technology in clinical medicine. They also identify key challenges that need to be addressed and provide a vision for the future development and prospects of 3D printed bone technology. With further advancements and refinements in 3D printing technology, we can expect this technique to play an increasingly important role in bone repair surgeries, ultimately leading to better patient outcomes and quality of life.

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