Biological aspects of Schiff base–metal complexes derived from benzaldehydes: an overview

Mohapatra, Ranjan K.; Das, Pradeep; Pradhan, Manoj Kumar; Maihub, A. A.; El-ajaily, M. M.

doi:10.1007/s13738-018-1411-2

Cited by 30 publications

(12 citation statements)

References 146 publications

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“…Among the series, most of the compounds showed moderate antioxidant activity with IC50 values ranging from 249.63 to 945. 23 The results revealed that bis-sulfonamide Schiff base derivatives (7)(8)(9)(10)(11)(12)(13)(14)(15) showed no significant activity in case of DPPH free radical scavenging method with IC50 values of >1000 µM. In the present work, all compounds were less active than the standard BHA (61.72 µM), BHT (232.11 µM), and α-Toc (56.86 µM) (Table 1) in case of DPPH free radical scavenging method.…”

Section: Resultsmentioning

confidence: 52%

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Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors

Lolak

Akocak

2020

Cumhuriyet Science Journal

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Aromatic/heterocyclic Schiff bases are one of the most investigated and studied scaffold for many pharmaceutical applications. For this reason, in the current work, a series of aromatic bis-sulfonamide Schiff bases (7-15) were re-synthesized by reacting aromatic bis-aldehydes and aromatic sulfonamides in ethanol and assayed for antioxidant properties by using different bioanalytical methods such as DPPH free radical scavenging assay, ABTS cation radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition profiles were also assessed. In general, the synthesized compounds showed weak antioxidant activity against all tested methods, but two compounds (12 and 15) showed good CUPRAC activity at 10, 25 and 50 µM concentrations. The weak inhibition potency was obtained against AChE and moderate activity was observed against BChE enzymes at 200 µM.

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Section: Resultsmentioning

confidence: 52%

“…Schiff bases and their metal complexes were extensively studied as a potential antioxidant regeants [23,24]. Specifically, a histamine Schiff bases were recently evaulated as an antioxidant and cholineterase inhibitors by us [20].…”

Section: Resultsmentioning

confidence: 99%

Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors

Lolak

Akocak

2020

Cumhuriyet Science Journal

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“…Schiff base complexes have been synthesized from the condensation of 4-amino-N(quinoxalin-2-yl) benzenesulfonamide 1 with 4-chloro-benzaldehyde according to the reported in the literature [17,18]. The compound was prepared with high yield and purity via stirring of 1 with 4-chloro-benzaldehyde at 70-100 °C.…”

Section: Methodsmentioning

confidence: 99%

“…Inhibitor + n H ads à inhibitor ads + H 2 (17) or by displacement water molecules of the surface as equation (14) Organic molecules maybe adsorbed on the mild steel surface in four ways namely; (і) electrostatic interaction between the charged molecules and the charged metal, (іi) interaction of unshared electron pairs in the molecule with the metal, (iii) interaction of π-electrons with the metal and (iv) a combination of types (i-iii) [10]. Due to adsorption, inhibitor molecules block the reaction sites and reduce the rate of corrosion reaction.…”

Section: Mechanism Of Corrosion Inhibition Mechanism Of Mild Steel Comentioning

confidence: 99%

Corrosion inhibition of two Schiff base complexes on the mild steel in 1M HCl solution

Taha

Mohamed²,

Ghanem

2019

Egypt. J. Chem.

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C ORROSION inhibition of two Schiff base complexes were examined for mild steel in 1M HCl solution. These two Schiff base complexes, Cd(II) and UO2(II) were synthesized through the reaction of CdCl 2 .H 2 O and UO 2 (NO 3) 2 .6H 2 O with the Schiff base ligand N-carbamimidoyl-4-((4-chlorobenzylidene)-amino) benzenesulfonamide in ethanol. The corrosion behavior was studied for the mild steel by weight loss method, Open circuit potential measurements (OCP), Potentiodynamic polarization, and Electrochemical impedance spectroscopy (EIS). The compounds have a promising corrosion inhibition materials for the mild steel in the investigated acid medium.

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“…Schiff bases derived from the condensation of an amino and a carbonyl compound, form an important class of ligands that have the propensity to bind almost all metal ions via azomethine nitrogen . The chemistry of such compounds has been studied extensively over past few decades . Several azomethine and their metal complexes have been reported to exhibit a broad range of biological activities, including antifungal, antibacterial, antimicrobial, antioxidant, and anticancer properties.…”

Section: Introductionmentioning

confidence: 99%

Transition Metal Complexes of (E)‐2((2‐hydroxybenzylidene) amino‐3‐mercaptopropanoic acid: XRD, Anticancer, Molecular modeling and Molecular Docking Studies

El-ajaily

Sarangi²,

Mohapatra³

et al. 2019

ChemistrySelect

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The anticancer studies of a Schiff base; (E)-2((2-hydroxybenzylidene)amino-3-mercaptopropanoic acid (H 2 L) (obtained from 2hydroxybenzaldehyde and L-cysteine) and its transition metal complexes have been reported. The evaluation of the growth inhibitory action was studied for the compounds against human colon carcinoma (HCT-116), human hepatocellular liver carcinoma (HEPG-2), normal melanocytes (HFB-4) and human breast carcinoma (MCF-7) cell lines. The obtained results revealed that the Schiff base and its chelates are active against human hepatocellular liver carcinoma (HEPG-2) cell lines. The powder X-ray diffraction analysis for the compounds was carried out through Phillips X'Pert High score software. The density functional theory computation for ligand and Co(II), Ni (II) and Cu(II) metal complexes were made to understand the mode of bonding by GAUSSIAN 03 rev. A.01 programme. The quantitative structure-activity relationship investigation was performed by using HyperChem Professional 8.0.3 software to understand the biological potency of the ligands. Moreover, a docking analysis using iGEMDOCKv2.1 software was carried out against the kinase enzyme PDB ID:1fvv.[a] M. M. El-ajaily, R. N. Eldaghare

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Biological aspects of Schiff base–metal complexes derived from benzaldehydes: an overview

Cited by 30 publications

References 146 publications

Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors

Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors

Corrosion inhibition of two Schiff base complexes on the mild steel in 1M HCl solution

Transition Metal Complexes of (E)‐2((2‐hydroxybenzylidene) amino‐3‐mercaptopropanoic acid: XRD, Anticancer, Molecular modeling and Molecular Docking Studies

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