Biological Applications

doi:10.1002/0470011149.ch7

Cited by 7 publications

(1 citation statement)

References 37 publications

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“…3 ) stretching vibrations [35][36][37] . The lipidomic profile in plasma include both free lipids (cholesterol, triglycerides, phospholipids, fatty acids) and protein-bound lipids.…”

Section: Resultsmentioning

confidence: 99%

ATR-FTIR spectroscopy of plasma supported by multivariate analysis discriminates multiple sclerosis disease

Crocco

Moyano

Annesi

et al. 2023

Sci Rep

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Multiple sclerosis (MS) is one of the most common neurodegenerative diseases showing various symptoms both of physical and cognitive type. In this work, we used attenuated total reflection Fourier transformed infrared (ATR-FTIR) spectroscopy to analyze plasma samples for discriminating MS patients from healthy control individuals, and identifying potential spectral biomarkers helping the diagnosis through a quick non-invasive blood test. The cohort of the study consists of 85 subjects, including 45 MS patients and 40 healthy controls. The differences in the spectral features both in the fingerprint region (1800–900 cm−1) and in the high region (3050–2800 cm−1) of the infrared spectra were highlighted also with the support of different chemometric methods, to capture the most significant wavenumbers for the differentiation. The results show an increase in the lipid/protein ratio in MS patients, indicating changes in the level (metabolism) of these molecular components in the plasma. Moreover, the multivariate tools provided a promising rate of success in the diagnosis, with 78% sensitivity and 83% specificity obtained through the random forest model in the fingerprint region. The MS diagnostic tools based on biomarkers identification on blood (and blood component, like plasma or serum) are very challenging and the specificity and sensitivity values obtained in this work are very encouraging. Overall, the results obtained suggest that ATR-FTIR spectroscopy on plasma samples, requiring minimal or no manipulation, coupled with statistical multivariate approaches, is a promising analytical tool to support MS diagnosis through the identification of spectral biomarkers.

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“…3 ) stretching vibrations [35][36][37] . The lipidomic profile in plasma include both free lipids (cholesterol, triglycerides, phospholipids, fatty acids) and protein-bound lipids.…”

Section: Resultsmentioning

confidence: 99%

ATR-FTIR spectroscopy of plasma supported by multivariate analysis discriminates multiple sclerosis disease

Crocco

Moyano

Annesi

et al. 2023

Sci Rep

View full text Add to dashboard Cite

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Performance appraisal of microbial inoculants treating polluted surface water through bench‐scale investigation

Simon

Joshi

Hazra

2023

J of Chemical Tech & Biotech

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BACKGROUNDThis study investigates the performance of microbial inoculants by exploring pollutant removal efficiency, microbial viability and substrate removal kinetics for treating polluted surface water. The morphological, elemental composition and biochemical characterization of inoculants were analyzed using field emission scanning electron microscopy with energy dispersive X‐ray spectroscopy (FESEM‐EDX) and Fourier transform infrared (FTIR) techniques. The identification of bacterial strains in polluted feed water also was performed using 16S rRNA partial sequencing. Bench‐scale efficacy of selected microbial inoculants (MI) along with control for each study was performed at variable retention times ranging from 6 to 72 h, under optimum operating conditions.RESULTSThe maximum removal (86% and 90%) of the organic load (chemical and biological oxygen demand, COD and BOD) was achieved by inoculants containing Bacillus subtilis along with other microbial species after 72 h of treatment. The microbial inoculant MI‐2 containing Paracoccus pantotrophus and Pseudomonas Putida exhibited the highest TN removal (66%) after 72 h of contact time. Adenosine triphosphate (ATP) analysis revealed that the active biomass ratio is a more precise indicator of healthy biomass instead of the conventionally used parameter MLVSS (mix liquor volatile suspended solids) in a biological treatment system, which apparently provides a significant addition to the existing knowledge base for the operational wastewater treatment plants (WTPs).CONCLUSIONIn this study, microbial inoculants were found to be frugal and viable treatment tools for the remediation of polluted surface water. Exploiting such inoculants also can overcome the inefficiencies of existing sewage treatment plants by serving as potential tools for bio‐augmenting the indigenous microbial fingerprint of aeration tank/secondary treatment systems. © 2023 Society of Chemical Industry (SCI).

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A new uranium bioremediation approach using radio-tolerant Deinococcus radiodurans biofilm

et al. 2019

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Biological Applications

Cited by 7 publications

References 37 publications

ATR-FTIR spectroscopy of plasma supported by multivariate analysis discriminates multiple sclerosis disease

ATR-FTIR spectroscopy of plasma supported by multivariate analysis discriminates multiple sclerosis disease

Performance appraisal of microbial inoculants treating polluted surface water through bench‐scale investigation

A new uranium bioremediation approach using radio-tolerant Deinococcus radiodurans biofilm

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