Biological applications of lipoic acid-based polymers: an old material with new promise

Yu, Qing; Fang, Zhiyue; Luan, Shifang; Wang, Lei; Shi, Hengchong

doi:10.1039/d4tb00581c

Cited by 1 publication

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References 79 publications

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“…Table 3. Advantages and limitations of the most common methods used to synthesise poly(α-lipoic acid) nanoparticles [181].…”

Section: Poly(α-lipoic Acid)-based Polymeric Nanoparticles: Insights ...mentioning

confidence: 99%

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Bellini,

Mancin,

Papini

et al. 2024

Antioxidants

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α-lipoic acid is a naturally occurring compound with potent antioxidant properties that helps protect cells and tissues from oxidative stress. Its incorporation into nanoplatforms can affect factors like bioavailability, stability, reactivity, and targeted delivery. Nanoformulations of α-lipoic acid can significantly enhance its solubility and absorption, making it more bioavailable. While α-lipoic acid can be prone to degradation in its free form, encapsulation within nanoparticles ensures its stability over time, and its release in a controlled and sustained manner to the targeted tissues and cells. In addition, α-lipoic acid can be combined with other compounds, such as other antioxidants, drugs, or nanomaterials, to create synergistic effects that enhance their overall therapeutic benefits or hinder their potential cytotoxicity. This review outlines the advantages and drawbacks associated with the use of α-lipoic acid, as well as various nanotechnological approaches employed to enhance its therapeutic effectiveness, whether alone or in combination with other bioactive agents. Furthermore, it describes the engineering of α-lipoic acid to produce poly(α-lipoic acid) nanoparticles, which hold promise as an effective drug delivery system.

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“…Table 3. Advantages and limitations of the most common methods used to synthesise poly(α-lipoic acid) nanoparticles [181].…”

Section: Poly(α-lipoic Acid)-based Polymeric Nanoparticles: Insights ...mentioning

confidence: 99%

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Bellini,

Mancin,

Papini

et al. 2024

Antioxidants

View full text Add to dashboard Cite

show abstract

Biological applications of lipoic acid-based polymers: an old material with new promise

Abstract: Lipoic acid (LA) is a versatile antioxidant to be used in various oxidation-reducing diseases over the past 70 years. Attributing to the large five-membered ring tension, the dynamic disulfide bond...

Cited by 1 publication

References 79 publications

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

Nanotechnological Approaches to Enhance the Potential of α-Lipoic Acid for Application in the Clinic

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