Biological Applications of Foldamers

Koyack, Marc J.; Cheng, Richard P.

doi:10.1002/9783527611478.ch8

Cited by 4 publications

(3 citation statements)

References 248 publications

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“…Thus, one major line of development in foldamer chemistry is the investigation of function; for example, biological activity [2,3] and molecular-recognition properties. [4,5] However, even in nature, isolated secondary structures achieve little function relative to tertiary or quaternary structures.…”

Section: Nicolas Delsucmentioning

confidence: 99%

Metal‐Directed Dynamic Formation of Tertiary Structure in Foldamer Assemblies: Orienting Helices at an Angle

Delsuc¹,

Hutin²,

Campbell³

et al. 2008

Chemistry A European J

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Unter 15 GPa bei 1300 K entsteht CaCuII3FeIV4O12, das bei 210 K eine Ladungsdisproportionierung eingeht (2 FeIV→FeIII+FeV) und seine elektrischen und magnetischen Eigenschaften sowie seine Struktur verändert. Die FeIIIO6‐ und FeVO6‐Oktaeder sind wie die Ionen einer Steinsalzstruktur angeordnet (siehe Bild; Ca grau, O blau, Cu rot); die Tieftemperaturphase CuII(S=1/2,↓)3FeIII(S=5/2,↑)2 FeV(S=3/2,↑)2 ist ferrimagnetisch.

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Section: Nicolas Delsucmentioning

confidence: 99%

Metal‐Directed Dynamic Formation of Tertiary Structure in Foldamer Assemblies: Orienting Helices at an Angle

Delsuc¹,

Hutin²,

Campbell³

et al. 2008

Chemistry A European J

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“…[4][5][6][7][8][9][10][11][12][13] Designing molecules with well-defined secondary structures not only contribute towards a better understanding of the structural evolution of biological macromolecules but can also lead to the creation of useful self-assembled architectures for the applications in selective absorption, catalytic activities, transport and separation processes. [14][15][16] A de-novo design of foldamers involves the identification of structural elements which are capable of invoking the higher-order architectures. Although the early work on foldamers involved the use of biotic precursors to mimic higher-order structures in the laboratory environment, the field has been growing rapidly in the last two decades with the discoveries of diverse abiotic structural precursors leading to a variety of applications.…”

Section: Introductionmentioning

confidence: 99%

Hierarchy of π-Stacking Determines the Conformational Preference of Bis-Squaraines

Singh¹,

Singh²,

Patwari

2020

Preprint

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The rational design of conformationally controlled foldable modules can lead to a deeper insight into the conformational space of complex biological molecules where non-covalent interactions such as hydrogen bonding and π-stacking are known to play a pivotal role. Squaramides are known to have excellent hydrogen bonding capabilities and hence, are ideal molecules for designing foldable modules that can mimic the secondary structures of bio-molecules. The π-stacking induced folding of bis-squaraines tethered using aliphatic primary and secondary-diamine linkers of varying length is explored with a simple strategy of invoking small perturbations involving the length linkers and degree of substitution. Solution phase NMR investigations in combination with molecular dynamics simulations suggest that bis-squaraines predominantly exist as extended conformations. Structures elucidated by X-ray crystallography confirmed a variety of folded and extended secondary conformations including hairpin turns and 𝛽-sheets which are determined by the hierarchy of π-stacking relative to N–H···O hydrogen bonds.

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“…Nonetheless, other foldamer properties have been intensely investigated in recent years, in particular their potential to interfere with biological functions. [4] At first glance, the idea of using synthetic foldamers as potential therapeutic agents is not obvious, because they are generally much larger-typically between 0.5 and 5 kDa-than conventional drugs. However, size can also help solve problems that are hard to tackle with smaller molecules.…”

mentioning

confidence: 99%