Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway

Talebi, Marjan; Talebi, Mohsen; Farkhondeh, Tahereh; Samarghandian, Saeed

doi:10.1002/ptr.6905

Cited by 43 publications

(22 citation statements)

References 93 publications

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“…An intake of thymoquinone in middle-aged rats led to the normalization of expression in eNOS and Ca 2+ -activated K + channels. Moreover, components of the angiotensin system and oxidative stress were returned to normal by this phytoconstituent of Nigella sativa [289,290].…”

Section: Monoterpenesmentioning

confidence: 95%

An Overview of NO Signaling Pathways in Aging

et al. 2021

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Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions. NO production, its effects, and its efficacy, are extremely sensitive to aging-related changes in the cells. Herein, we review the mechanisms of NO signaling in the cardiovascular system, central nervous system (CNS), reproduction system, as well as its effects on skin, kidneys, thyroid, muscles, and on the immune system during aging. The aging-related decline in NO levels and bioavailability is also discussed in this review. The decreased NO production by endothelial nitric oxide synthase (eNOS) was revealed in the aged cardiovascular system. In the CNS, the decline of the neuronal (n)NOS production of NO was related to the impairment of memory, sleep, and cognition. NO played an important role in the aging of oocytes and aged-induced erectile dysfunction. Aging downregulated NO signaling pathways in endothelial cells resulting in skin, kidney, thyroid, and muscle disorders. Putative therapeutic agents (natural/synthetic) affecting NO signaling mechanisms in the aging process are discussed in the present study. In summary, all of the studies reviewed demonstrate that NO plays a crucial role in the cellular aging processes.

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Section: Monoterpenesmentioning

confidence: 95%

An Overview of NO Signaling Pathways in Aging

et al. 2021

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“…Through the same molecular docking analysis piceatannol also has shown neuroprotective responses ( Zhang et al, 2018 ; Talebi et al, 2020 ) with the potential of binding to ACE2, thereby playing a critical role in the prevention and treatment of COVID-19 ( Wahedi et al, 2020 ; Ahmad et al, 2020 ). The phytochemicals, baicalin, scutellarin, and hesperetin, also bind to ACE2, regarding reducing neurological symptoms in COVID-19 ( Cheng et al, 2020a ).…”

Section: Potential Of Phytochemicals Against Covid-19 Neurological Asmentioning

confidence: 98%

“…Evaluated by molecular docking analysis, dithymoquinone (a quinone, Figure 2 ) showed neuroprotective responses ( Zhang et al, 2018 ; Talebi et al, 2020 ) through binding to ACE2, to show key roles in the prevention and treatment of COVID-19 ( Wahedi et al, 2020 ; Ahmad et al, 2020 ). As a potential phytochemical of Nigella sativa L. (Ranunculaceae), dithymoquinone, with binding affinity of -8.6 kcal/mol, showed a higher potential of binding at SARS-CoV-2 ACE2 ( Ahmad et al, 2020 ).…”

Section: Potential Of Phytochemicals Against Covid-19 Neurological Asmentioning

confidence: 99%

Targeting Neurological Manifestations of Coronaviruses by Candidate Phytochemicals: A Mechanistic Approach

et al. 2021

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The novel coronavirus 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a wide range of manifestations. In this regard, growing evidence is focusing on COVID-19 neurological associations; however, there is a lack of established pathophysiological mechanisms and related treatments. Accordingly, a comprehensive review was conducted, using electronic databases, including PubMed, Scopus, Web of Science, and Cochrane, along with the author’s expertize in COVID-19 associated neuronal signaling pathways. Besides, potential phytochemicals have been provided against neurological signs of COVID-19. Considering a high homology among SARS-CoV, Middle East Respiratory Syndrome and SARS-CoV-2, revealing their precise pathophysiological mechanisms seems to pave the road for the treatment of COVID-19 neural manifestations. There is a complex pathophysiological mechanism behind central manifestations of COVID-19, including pain, hypo/anosmia, delirium, impaired consciousness, pyramidal signs, and ischemic stroke. Among those dysregulated neuronal mechanisms, neuroinflammation, angiotensin-converting enzyme 2 (ACE2)/spike proteins, RNA-dependent RNA polymerase and protease are of special attention. So, employing multi-target therapeutic agents with considerable safety and efficacy seems to show a bright future in fighting COVID-19 neurological manifestations. Nowadays, natural secondary metabolites are highlighted as potential multi-target phytochemicals in combating several complications of COVID-19. In this review, central pathophysiological mechanisms and therapeutic targets of SARS-CoV-2 has been provided. Besides, in terms of pharmacological mechanisms, phytochemicals have been introduced as potential multi-target agents in combating COVID-19 central nervous system complications.

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“…Furthermore, great lipophilicity of TQ makes poor formulation features. Numerous investigational studies have been done to avoid the pharmacokinetic difficulties of thymoquinone [23][24][25], and its contrary effect. An extremely promising and advanced approach to deal with the bioavailability matter and to realize even extra various potential health benefits is the usage of metal ion-TQ complex, forming a binary complex formation.…”

Section: Introductionmentioning

confidence: 99%

Bioactivities of holmium(III) and gadolinium(III) complexes of thymoquinone

Awwad¹,

Ibrahium²,

Shati³

et al. 2021

Bull. Chem. Soc. Eth.

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Chemotherapeutic agents which are the main stay in cancer treatment are toxic with numerous contrary side effects. A number of chemical, physical, and computational techniques were applied to synthesize and elucidate the structural and functional characterization of the new designed bioligands and their metal complexes. Besides, several biological techniques for developing therapeutics and diagnostics agents of these new designed materials were used. The trivalent holmium(III) and gadolinium(III) metal complexes of thymoquinone (TQ) were synthesized. Toxicities and other bioactivites were undertaken with existing drug combinations and more effective tumor models will be established. The molecular structures of TQ-metal complexes were elucidated based on particular spectral approaches. The NF-kB (nuclear factor kappa-light-chain enhancer of activated B Cells) luciferase, elastase release, superoxide anion (O2•−) generation, and DPPH (1,1-diphenyl-2-picryl hydrazyl) free-radical scavenging activities of TQ and its synthesized complexes were elucidated and discussed. The core research is to use coordination and organometallic chemistry to design new bioligands and binary, ternary, mixed ligand, multi metal multi ligand complexes pursing a bio target continuously with structure-activity relationships (SARS). KEY WORDS: Thymoquinone, Holmium, Gadolinium, Bioactivities Bull. Chem. Soc. Ethiop. 2021, 35(1), 87-96. DOI: https://dx.doi.org/10.4314/bcse.v35i1.7

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Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway

Cited by 43 publications

References 93 publications

An Overview of NO Signaling Pathways in Aging

An Overview of NO Signaling Pathways in Aging

Targeting Neurological Manifestations of Coronaviruses by Candidate Phytochemicals: A Mechanistic Approach

Bioactivities of holmium(III) and gadolinium(III) complexes of thymoquinone

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