Pre-eclampsia is extremely harmful to mothers and infants. It often leads to a series of poor prognosis such as fetal distress, fetal growth restriction, placental abruption, premature delivery, acute renal failure and so on. At present, there is no effective method for predicting preeclampsia at home and abroad, so further research is needed. The purpose of this article is to analyze the relationship between serological indicators and preeclampsia by observing and analyzing the serological indicators of clinical testing, to understand the role of clinical testing serological indicators in the prediction of preeclampsia, and to the pre-eclampsia clinical testing serological indicators before and after In contrast, study the relationship between clinical test serological indicators and preeclampsia. Using the method of this article, through the analysis of experimental data, we understand the role of clinical test serological indicators in the prediction of preeclampsia, and find that clinical test serological indicators play an important role. Through the combination of theory and experimental data, we analyze the clinical test serology the predictive effect of the indicator in preeclampsia reached 84.6%. The research results show that HCG value can be used as one of the factors for predicting preeclampsia. According to these indicators, effective prediction of preeclampsia is provided, which provides a real basis for clinical prediction of preeclampsia, and finds a breakthrough from the prediction of PE to reduce the incidence of PE and improve the prognosis of pregnant women and fetuses of PE.