Biological and Molecular Docking Evaluation of a Benzylisothiocyanate Semisynthetic Derivative From Moringa oleifera in a Pre-clinical Study of Temporomandibular Joint Pain

Abstract

Graphical AbstractSemisynthetic derivative from Moringa oleifera on temporomandibular joint pain.

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

“…Pods and seeds Inhibited beta-hexosaminidase, histamine, IL-4, and TNF-α release [12] Antiatherosclerotic Leaves Reduced cholesterol levels and reduced atherosclerotic plaque to 50% and 86%, respectively [13] Anticonstipation Flowers and leaves Adjusted stool number, weight and water contents of feces, and recovered the thickness of colon muscles and mucus [14] Antihelminthic Seeds Delayed the development of Aedes aegypti larvae, Anopheles stephensi Liston, and helminth eggs in irrigation water [15][16][17][18] Anti-infammatory Seeds, leaves, and roots Downregulated TNF-α and interleukin-1β, and improved IL-6 [19][20][21][22][23] Anticlastogenic Leaves and pods Decreased number of micronucleated peripheral reticulocytes [24,25] Anticonvulsant Leaves and roots Enhanced the inhibitory mechanism through the release c-amino butyric acid (GABA) [26] Antinociceptive Leaves Reduced the protein levels of ICAM-1 (intercellular adhesion molecule 1) and CD55 [27] Antioxidant Leaves and seeds Included antioxidant agents such as vitamins, minerals, and phenols [28] Antipyretic Leaves Decreased body temperature [29] Antispasmodic Leaves and seeds Inhibited the release of acetylcholine [30] Antitumor Seeds, leaves, and roots Reduced the tumor weight and progression [31] Antiulcerogenic Leaves and seeds Increased the volume of gastric juice, PGE 2 , IL-10, and GSH [32][33][34] Bactericidal Leaves, stems, pods, and seeds Showed antibacterial efect against Staphylococcus aureus, Vibrio cholerae, and Escherichia coli [35][36][37] Diuretic Seeds Increased urine output and increased urine volume and concentration [30,38] Fungicide Leaves, seeds, and roots Showed antifungal activities against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton foccosum, and Microsporum canis [39,40] Hepatoprotective Seeds and leaves Enhanced plasma protein levels, reduced hepatic dysfunction markers, and regenerated hepatic ...…”

Moringa oleifera Use in Maintaining Oral Health and Its Potential Use in Regenerative Dentistry

“…In another in vivo study of temporomandibular joint pain using male Wistar rats, the semisynthetic derivative MC-H exhibited antinociceptive and anti-inflammatory effects when administered orally. This potential analgesic effect could be peripherally mediated by action of the heme oxygenase-1 (HO-1) pathway, as well as through inhibition of intercellular adhesion molecule levels while centrally by the activation of opioid receptors ( µ and δ ) [ 41 ].…”