Biological and Molecular Characterization of a Pigeon Paramyxovirus Type-1 Isolate Found in Argentina

Zanetti, Flavia; Mattiello, Rosana; Garbino, Cesar; Kaloghlian, Analia; Terrera, M. V.; Boviez, Juan; Palma, Eduardo L.; Carrillo, Elisa; Berinstein, Analía

doi:10.2307/1592896

Cited by 26 publications

(18 citation statements)

References 7 publications

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“…Several outbreaks in Columbiformes have been reported over the past 30 years in many parts of the world caused by an adapted variant AAvV-1 denominated pigeon paramyxovirus 1 (PPMV-1) (Alexander 2011), which have been described in countries of the South America (Zanetti et al 2001). These panzootic strains belong to genotype VI, which presents 9 subgenotypes (Dimitrov et al 2016), and has been previously described in high mortality outbreaks worldwide in different species of birds (Alexander et al 1985(Alexander et al , 1997.…”

Section: Introductionmentioning

confidence: 99%

Pathological and molecular findings of avian avulavirus type 1 outbreak in pigeons (Columba livia) of southern Brazil

et al. 2018

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The Newcastle disease, caused by avian avulavirus type 1 strains (APMV-1) is an important avian disease involved into high rates of mortality and economic losses. Several outbreaks have been reported over the last 30 years in Columbiformes in different parts of the world, caused by a adapted variant strain of AAvV-1, called pigeon paramyxovirus type 1 (PPMV-1). A high mortality associated with an outbreak was analyzed in free-living pigeons (Columba livia) in a public square in Porto Alegre in Southern Brazil. A total of 24 pigeons moribund or freshly dead, within five weeks interval were submitted to necropsy, histopathological, immunohistochemical (anti-Newcastle), and RT-PCR followed by sequencing of the amplification products analysis. They presented neurological signs, non-suppurative encephalitis and encephalomyelitis, and mononuclear inflammatory infiltrate in different organs. Immunohistochemical analysis in nine pigeons tissue showed that anti-Newcastle was expressed in brain, kidney, liver and pancreas. The RT-PCR test for the M protein of Newcastle disease virus was positive in six pigeons. The differential diagnosis of Influenza, West Nile, Mycoplasma gallisepticum and Mycoplasma synoviae in all pigeons presented negative results. The sequence of amino acids in the cleavage site region of the F protein was 112RRQKRF117 classifying the strain as virulent. The phylogenetic analysis classified this virus strain into Class II and VI genotype.

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Section: Introductionmentioning

confidence: 99%

Pathological and molecular findings of avian avulavirus type 1 outbreak in pigeons (Columba livia) of southern Brazil

et al. 2018

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“…Avian paramyxoviruses, including Newcastle disease virus, are common domestic and wild bird pathogens [27][28][29][30]. Paramyxovirus type-1 can be found in pigeons worldwide [31][32][33][34] but the clinical signs vary depending on the immunity of the host and virulence of the specific isolates [35]. While human infection with Newcastle disease virus is rare, at least two outbreaks of conjunctivitis due to Newcastle disease virus have been reported in poultry workers [28,36,37].…”

Section: Introductionmentioning

confidence: 99%

The Viruses of Wild Pigeon Droppings

et al. 2013

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Birds are frequent sources of emerging human infectious diseases. Viral particles were enriched from the feces of 51 wild urban pigeons (Columba livia) from Hong Kong and Hungary, their nucleic acids randomly amplified and then sequenced. We identified sequences from known and novel species from the viral families Circoviridae, Parvoviridae, Picornaviridae, Reoviridae, Adenovirus, Astroviridae, and Caliciviridae (listed in decreasing number of reads), as well as plant and insect viruses likely originating from consumed food. The near full genome of a new species of a proposed parvovirus genus provisionally called Aviparvovirus contained an unusually long middle ORF showing weak similarity to an ORF of unknown function from a fowl adenovirus. Picornaviruses found in both Asia and Europe that are distantly related to the turkey megrivirus and contained a highly divergent 2A1 region were named mesiviruses. All eleven segments of a novel rotavirus subgroup related to a chicken rotavirus in group G were sequenced and phylogenetically analyzed. This study provides an initial assessment of the enteric virome in the droppings of pigeons, a feral urban species with frequent human contact.

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“…However, in 1984, multiple ND outbreaks in Great Britain were initiated by PPMV1 and spread from pigeons to chickens (Alexander et al, 1985b). Subsequently, PPMV1 has been responsible for other chicken ND outbreaks worldwide (Aldous et al, 2004;Capua et al, 2002;Kommers et al, 2001;Liu et al, 2006;OIE, 2011a,b;Toro et al, 2005;Werner et al, 1999) and has caused extensive panzootic infections in racing pigeons in European countries despite vaccination efforts (Alexander et al, 1997;Kommers et al, 2001;Meulemans et al, 2002;Werner et al, 1999;Zanetti et al, 2001). Genetic analysis of PPMV1 demonstrated that this strain, named genotype VI-PMV1 (GVI-PMV1) (Aldous et al, 2004), constituted a distinct monophyletic lineage with considerable genetic heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

Successful establishment and global dispersal of genotype VI avian paramyxovirus serotype 1 after cross species transmission

Chong

Lam

Kim

et al. 2013

Infection, Genetics and Evolution

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The evolutionary history of avian paramyxovirus serotype 1 (PMV1), which includes the agents of Newcastle disease (ND), is characterized by a series of strain emergence events since viruses in this family were first recognized in the 1920s. Despite the importance of ND to the poultry industry, little is known about PMV1 strain emergence events and the subsequent dispersal and evolution of new strains. The genotype VI-PMV1 was first identified in the 1980s and has been named pigeon paramyxovirus-1 (PPMV1) because of unusual host specificity with Columbiformes (Collins et al., 1996); it has been responsible for panzootics in both chickens and pigeons during that time. Here, we used evolutionary analyses to characterize the emergence of this contemporary PMV1 lineage. We demonstrate that GVI-PMV1 arose through cross-species transmission events from Galliformes (i.e. chicken) to Columbiformes, and quickly established in pigeon populations. Our studies revealed a close association between the time of viral emergence and panzootic events of this virus. The virus appeared first in Southeastern Europe and quickly spread across the European continent, which became the epicenter for global virus dissemination. With new viral gene sequences, we show that GVI-PMV1 viruses currently circulating in North America resulted from multiple invasion events from Europe, one associated with an exotic European Columbiformes species, and that extant lineages have diversified locally. This study extends our understanding of successful viral emergence subsequent to cross-species transmission and dispersal patterns of newly emerged avian viruses, which may improve surveillance awareness and disease control of this and other important avian pathogens.

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Biological and Molecular Characterization of a Pigeon Paramyxovirus Type-1 Isolate Found in Argentina

Cited by 26 publications

References 7 publications

Pathological and molecular findings of avian avulavirus type 1 outbreak in pigeons (Columba livia) of southern Brazil

Pathological and molecular findings of avian avulavirus type 1 outbreak in pigeons (Columba livia) of southern Brazil

The Viruses of Wild Pigeon Droppings

Successful establishment and global dispersal of genotype VI avian paramyxovirus serotype 1 after cross species transmission

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