Biological and Mechanical Factors and Epigenetic Regulation Involved in Tendon Healing

Li, Zhi Jie; Yang, Qiaoyuan

doi:10.1155/2023/4387630

Cited by 6 publications

(3 citation statements)

References 184 publications

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“…Because of the hypocellular and hypovascular characteristics of the tissue of the tendon, the triphasic normal therapeutic reaction is somewhat sluggish, thereby necessitating surgical intervention ( Long et al, 2022 ). The three steps of the natural healing response are 1) inflammation, 2) propagation/restoration, and 3) remodeling ( Li et al, 2023 ). Throughout the inflammatory process, the blood clot that forms soon after an injury serves as “preliminary scaffolding,” and burst tendon veins produce chemoattractants that attract migratory cells (neutrophils, monocytes, and lymphocytes) from the nearby tissues ( Hafeez et al, 2021 ).…”

Section: Healing Of Tendon Tissue Through Natural Meansmentioning

confidence: 99%

An overview of the material science and knowledge of nanomedicine, bioscaffolds, and tissue engineering for tendon restoration

Liang

Zhou

Meng

et al. 2023

Front. Bioeng. Biotechnol.

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Tendon wounds are a worldwide health issue affecting millions of people annually. Due to the characteristics of tendons, their natural restoration is a complicated and lengthy process. With the advancement of bioengineering, biomaterials, and cell biology, a new science, tissue engineering, has developed. In this field, numerous ways have been offered. As increasingly intricate and natural structures resembling tendons are produced, the results are encouraging. This study highlights the nature of the tendon and the standard cures that have thus far been utilized. Then, a comparison is made between the many tendon tissue engineering methodologies proposed to date, concentrating on the ingredients required to gain the structures that enable appropriate tendon renewal: cells, growth factors, scaffolds, and scaffold formation methods. The analysis of all these factors enables a global understanding of the impact of each component employed in tendon restoration, thereby shedding light on potential future approaches involving the creation of novel combinations of materials, cells, designs, and bioactive molecules for the restoration of a functional tendon.

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Section: Healing Of Tendon Tissue Through Natural Meansmentioning

confidence: 99%

An overview of the material science and knowledge of nanomedicine, bioscaffolds, and tissue engineering for tendon restoration

Liang

Zhou

Meng

et al. 2023

Front. Bioeng. Biotechnol.

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show abstract

“…Platelet-derived biomaterials, like TGF-β2, IGF-I, and VEGF, may mitigate these pathological features by promoting neural regeneration and nNOS upregulation. It has been shown that PDGF-β is a mitogen for Schwann cells with trophic activity on neurons because neuronal cells express PDGF receptors [71]. Higher levels of PDGF-β are found in peripheral neurons with damaged peripheral nerves, suggesting the importance of this protein for peripheral nerve regeneration [72].…”

Section: Platelet-rich Plasma (Prp) In Ed Treatmentmentioning

confidence: 99%

New developments in erectile dysfunction treatments: A role for regenerative medicine

FY Ashari,

Yufi AZ,

Cennikon P

2023

World J. Adv. Res. Rev.

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Erectile dysfunction is a highly prevalent issue related to the sexual wellness of millions of men worldwide. While conventional therapies have been successful for many, there remains a significant subset of individuals who do not respond adequately or experience undesirable side effects. This article reviews the emerging field of regenerative medicine as a potential breakthrough in the management of ED. Regenerative therapies, especially platelet-rich plasma (PRP) therapy along with stem cell therapy, provide novel approaches to tackling the fundamental causes of ED. By harnessing the body's natural healing mechanisms, these treatments hold promise for restoring erectile function and improving patients' quality of life. This review explores the mechanisms of action, benefits, and current research findings related to regenerative therapies for ED, emphasizing their potential to revolutionize the treatment landscape for this prevalent condition. As ongoing research continues to shed light on their safety and efficacy, regenerative therapies may pave the way for a brighter future in the management of erectile dysfunction.

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“…However, this process is usually slow and leads to the formation of lower scar tissue, which may take several years to reshape into more functional tissue. More serious injuries, such as acute mechanical loads and other physical factors, usually lead to tendon tears, which usually require surgical treatment [2,3].…”

Section: Introductionmentioning

confidence: 99%

Research progress in the treatment of tendon injury

2024

Third International Conference on Biological Engineering and Medical Science (ICBioMed2023)

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Tendons can withstand a lot of tension and can cushion muscle damage. Tendon injury is a common musculoskeletal disorder in life, which causes local pain, abnormal motor function and other symptoms. Clinical symptoms of chronic tendon injury or tendon disease include pain, decreased muscle strength, and decreased physical activity. Obesity, multiple strains, and overstretching are the most common causes of tendon injuries. The most common overuse tendon disorders include rotator cuff tendon, medial and lateral epicondylar elbow tendon, patellar tendon, gluteal tendon, and Achilles tendon. In most cases, tendon injuries do not require surgery. However, this process is usually slow and leads to the formation of lower scar tissue. More severe injuries, such as acute mechanical loading and other physical factors, usually result in tendon tears that require treatment. There are several treatment options available for tendon injuries, such as Physical therapy, Cold compress therapy, Gene therapy, Surgery, etc. None has been shown to result in a sustained and near complete recovery, and conservative treatment is the most reliable treatment. It is also particularly important to prevent adhesions from occurring during the tendon healing process. This review presents the main therapies for tendon injuries from two different types of medicine, Chinese and Western.

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Biological and Mechanical Factors and Epigenetic Regulation Involved in Tendon Healing

Cited by 6 publications

References 184 publications

An overview of the material science and knowledge of nanomedicine, bioscaffolds, and tissue engineering for tendon restoration

An overview of the material science and knowledge of nanomedicine, bioscaffolds, and tissue engineering for tendon restoration

New developments in erectile dysfunction treatments: A role for regenerative medicine

Research progress in the treatment of tendon injury

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